EFFECT OF A DEXTRANE AND HYDROPHILIZING SUBSTANCES ON THE PROPERTIES OF THERMOSENSITIVE HYDROPHILIC GELS CONTAINING LACTIC ACID COMPLEXED WITH CHITOSAN

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Gels containing lactic acid complexed with chitosan at a stechiometric ratio 1:1 and 2:1 and 5-25% content of PEG-200 reveal pH from 3.42 to 4.95. The addition of 20 – 25% poloxamer 407 increases the pH from 4.55 to 5.30 for 1:1 gels and from 4.00 to 4.85 for 2:1 gels.
The addition of 1.0% dextrane decreases the pH of investigated gels from 4.40 to 4.90 (1:1) and from 4.00 to 4.48 (2:1).
The addition of poloxamer 407 at concentrations of 20 to 25% increases the dynamic viscosity from 506.14 to 641.20 for 1:1 and from 540.35 to 692.55 for 2:1 ratios.
The addition of 1.0% dextrane increases the dynamic viscosity from 665.23 to 750.28 for 1:1 and from 645.50 to 740.16 for 2:1 ratios.
The addition of dextrane and glycerol or 1,2-propylene glycol reduces the pH and maintains high adhesion. The use of dextrane and hydrophilizing substances allowed to obtain physiological range pH.

Keywords

EN

1; 2- propylene glycol; dextrane; glycerol; lactic acid complexed with chitosan; thermosensitive polymer - poloxamer 407; vaginal infections

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 115-122

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Faculty of Pharmacy, "Silesian Piast" memorial Medical University of Wroclaw

References

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• Document Type: article