The Serum Lipid Profile of Hypertensive Patients in Isiala Mbano, Imo State, Nigeria

• Authors: Elendu Melford Uche , Ejiofor Dominic Chinedu , Iheukwumere Chinedu Berry , Chigaemezu Remmy-Martin Akubuo , Okereke Levi Kelechi
• Languages of publication: EN

Abstracts

EN

This research assessed the serum lipid profiles in patients with hypertension and explored their association with hypertension in Isiala Mbano, Imo State, Nigeria. A total of 127 participants, both male and female, aged 25 years and above, were recruited and divided into hypertensive (n = 80) and normotensive (n = 47) cohorts. Hypertension was identified based on the World Health Organization (WHO) guidelines after taking three consecutive blood pressure readings. Venous blood samples (5 mL) were collected in a sterile manner into plain tubes for biochemical evaluation. Serum concentrations of Total cholesterol (TC), Triglycerides (TG), High-density lipoprotein (HDL) cholesterol, and Low-density lipoprotein (LDL) cholesterol were measured using standardized enzymatic colorimetric techniques. TG exhibited a moderate positive correlation with both TC and HDL (p < 0.001). TC showed a strong positive correlation with HDL and LDL and a moderate positive correlation with TG (all p < 0.001). HDL presented a moderate positive correlation with TG and LDL (p < 0.001), while LDL demonstrated a moderate positive correlation with HDL and TG (p = 0.001). No noteworthy correlation was found between TG and LDL. The hypertensive individuals in this study displayed dyslipidaemic characteristics, with significant positive inter-correlations among different lipid fractions. It is recommended that routine lipid profile evaluations and the early treatment of dyslipidaemia be incorporated into hypertension management to diminish cardiovascular risk.

Keywords

EN

Cardiovascular risk; Dyslipidaemia; Hypertension; Serum lipid profile

Discipline

• MEDICINE: MEDICINE

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2025
• Volume: 63
• Issue: 2
• Pages: 93-101

Contributors

author

Elendu Melford Uche

• Department of Human Physiology, Faculty of Basic Medical Science, College of Medicine, David Umahi Federal University of Health Sciences, Uburu Ebonyi State, Nigeria

author

Ejiofor Dominic Chinedu

• Department of Human Physiology, Faculty of Basic Medical Science, College of Medicine, David Umahi Federal University of Health Sciences, Uburu Ebonyi State, Nigeria

author

Iheukwumere Chinedu Berry

• Department of Human Physiology, Faculty of Basic Medical Science, College of Medicine, Abia State University, Uturu Abia State, Nigeria

author

Chigaemezu Remmy-Martin Akubuo

• Department of Medical Microbiology, Faculty of Biological Science, Imo State University, Owerri, Imo State, Nigeria

author

Okereke Levi Kelechi

• Department of Family Medicine, Federal University Teaching Hospital Owerri, Imo State, Nigeria

References

• [1] George Fogor. Primary prevention of CVD: Treating dyslipidaemia. American Family Physician 2011; 83(10), 1207-1208
• [2] Nelson RH. Hyperlipidaemia as a risk factor for cardiovascular disease; Primary care. Clinics in Office Practice 2013; 40: 195-211
• [3] Williams RR, Hunt SC, Hopkins PN. Familial dyslipidaemic hypertension. Evidence from 58 Utah families for a syndrome present in approximately 12% of patients with essential hypertension. Journal of the American Medical Association 1988; 24: 3579–3586
• [4] Halperin RO, Sesso HD, Ma J, Buring JE, Stampfer MJ, Gaziano JM. Dyslipidaemia and the risk of incident hypertension in men. J Hypertension 2006; 1: 45–50
• [5] Borghi C. Interactions between hypercholesterolemia and hypertension: implications for therapy. Current Opinion in Nephrology and Hypertension 2002; 5: 489–496
• [6] Neaton JD, Wentworth D. Serum cholesterol, blood pressure, cigarette smoking, and death from coronary heart disease: overall findings and differences by age for 316 099 white men. Archives of Internal Medicine 1992; 1: 56–64
• [7] World Health Organization. The definition of hypertension[Internet]. Geneva, Switzerland. World Health Organisation; 2015. Available from https://www.who.int>feautures
• [8] Schmieder RE. End organ damage in hypertension. Deutsches Arzteblatt International 2010; 107: 866-783
• [9] Harvey JM, Beevers DG, Biochemical investigation of hypertension. Annals of Clinical Biochemistry 1990; 4: 287–296
• [10] Lin CF, Chang HY, Chien SC, Lin YH, Yeh HY. Epidermiology of dyslipidaemia in the Asia pacific region. Intel J Gerontology 2018; 12: 2-16
• [11] Third Report of the National Cholesterol Education Program (NCEP), Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 2002; 106(25), 3143–3421
• [12] Rea A, Besial B. Dyslipidaemia associated with hypertension increases the risks for coronary heart disease: a case-control study in Harapan kita hospital, National cardiovascular centre, Jakarta. Journal of Lipids 2019; 1: 1-6
• [13] Charles UO, Emeka GO, Emmanuel IO, Gladys IA. Serum lipid profile of newly diagnosed hypertensive patients in Nnewi, South east Nigeria. Intel j Hypertension 2012; 1: 01-08
• [14] Allain CC. Enzymatic colorimetric determination of serum cholesterol. Clin Chem 1974; 20: 470-80
• [15] Trinder P. Enzymatic determination of triglyceride. Clin. Biol. Chem. 1969; 6: 24-30
• [16] Jinan Hussein Murtadha. Levels of Serum Lipid profile and Kidney Function Tests in Iraqi Hypertensive Patients: Duration Effect Study. Baghdad Science Journal 2017; Vol. 14, Iss. 2, Article 17. https://doi.org/10.21123/bsj.2017.14.2.0363
• [17] Akintunde AA. Epidemiology of conventional cardiovascular risk factors among hypertensive subjects with normal and impaired fasting glucose. South African Medical Journal 2010; 10: 594-597
• [18] Lepira FB, Mbuyamba JR, Kayembe KP, Nseka MN. Correlation of serum lipids and lipoprotein in Congolese patients with arterial hypertension. Cardiovascular Journal of South Africa 2005; 16: 249-255
• [19] Kesteloot H, Lee S, Park HM. A comparative study of serum lipids between Belgium and Korea. Circulation 1982; 16: 795-799
• [20] Edoziene JC. Establishment of biochemical for the evaluation of Nutrition status in West Africa. Assoc. Food 1965: 10(3): 3-21
• [21] Harvey JM, Beevers DG. Biochemical investigation of hypertension. Annals of Clinical Biochemistry 1990; 27: 287-296
• [22] Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993; 91: 2546-2551
• [23] Harrison DG, Armstrong ML, Freiman PC, Heistad DD. Restoration of endothelial-dependent relaxation by dietary treatment of atherosclerosis. J Clin Invest 1987; 80: 1808-1811
• [24] Grundy SM, Wilhelmsen L, Rose G. Coronary heart disease in high risk populations; Lesions from Finland. Eur Heart J 1990; 462-71
• [25] Robertson, Strong. Development of atherosclerosis in dogs with hypercholesterolemia and chronic hypertension. Lab Invest 1968; 2: 243
• [26] R H Grimm. Effects of thiazide diuretics on plasma lipids and lipoproteins in mildly hypertensive patients. Ann Int. Med 1981; 94: 7-11
• [27] Hart C, Ecob R, Smith GD. People, places and coronary heart disease risk factors: a multilevel analysis of the Scottish Heart Health Study archive. Soc Sci Med 1997; 45: 893-902
• [28] Vartiainen E, Pekkanen J, Koskinen S, Jousilahti P, Salomma V, Puska P. Do changes in cardiovascular risk factors explain the increasing socioeconomic difference in mortality from ischaemic heart disease in Finland? J Epidemiol Community Health. 198l; 52: 416-419
• [29] Singh RB, Beegom R, Ghosh S, Niaz MA, Rastogi V. Epidemiological study of hypertension and its determinants in an urban population of North India. J Hum Hypertens 1997; 11: 679-685
• [30] Whelton PK. Epidemiology of hypertension. Lancet 1994; 344: 101-106
• [31] Kadiri S. Current concepts in the management of hypertension. Dokita 1999; 26: 93-96
• [32] Shahid A, Zuberi SJ, Hasnain N. Lipid pattern in healthy subjects. Pak J Med Res 1985; 24: 33-37
• [33] Malik R, Pirzado ZA, Ahmed S, Sajid M. Study of lipid profile, blood pressure and blood glucose in rural population. Pak J Med Res. 1995; 34: 152-155
• [34] Prineas RJ, Gillum RF, Horibe H, Hannan PJ, The Minneapolis Children’s Blood Pressure Study. Part 1: standards of measurement for children’s blood pressure. Hypertension 1980; 2: I18-24
• [35] Reddy KS. Cardiovascular disease in non-Western countries. N Engl J Med 2004; 350: 2438–2440
• [36] Prabhanjan K, Moges B, Yohannes A. A study of lipid profiles in hypertensive patients visiting Dilla University Referral Hospital. Int J Sci Res. 2014; 3: 2336–2338
• [37] Wen W, Luo R, Tang X. Age-related progression of arterial stiffness and its elevated positive association with blood pressure in healthy people. Atherosclerosis 2015; 238: 147–152
• [38] Ferreira I, van de Laar RJ, Prins M. Carotid stiffness in young adults: a life-course analysis of its early determinants: the Amsterdam Growth and Health Longitudinal Study. Hypertension 2012; 59: 54–61
• [39] Alghatrif M, Strait B, Morrell. Longitudinal trajectories of arterial stiffness and the role of blood pressure: the Baltimore Longitudinal Study of Aging. Hypertension 2013; 62: 934–941
• [40] American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults [Internet]. 2017. Available at https://www.ahajournals.org/doi/pdf/10.1161

• Document Type: article