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2016 | 16 | 67 | 404–410

Article title

Granulomatous prostatitis after intravesical immunotherapy mimicking prostate cancer

Content

Title variants

PL
Ziarniniakowe zapalenie stercza po immunoterapii dopęcherzowej imitujące raka stercza

Languages of publication

EN PL

Abstracts

EN
Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive granulomatous prostatitis in a 61-year-old patient which occurred after the first course of a well-tolerated Bacillus Calmette-Guérin therapy is presented. Due to abnormalities found in rectal examination and an abnormal transrectal ultrasound image of the prostate with extensive infiltration mimicking neoplastic hyperplasia a core biopsy of the prostate was performed. Histopathological examination revealed inflammatory infiltration sites of tuberculosis origin.
PL
Immunoterapia dopęcherzowa oparta na podawaniu atenuowanych szczepów Mycobacterium bovis jest szeroko stosowaną opcją terapeutyczną u pacjentów z przejściowonabłonkowym rakiem pęcherza moczowego nienaciekającym mięśniówki. Rzadkim powikłaniem dopęcherzowej terapii szczepionką Bacillus Calmette-Guérin jest ziarniniakowe zapalenie stercza, które ze względu na narastanie swoistego antygenu sterczowego oraz nieprawidłowości w badaniu przezodbytniczym stercza może sugerować współistnienie raka stercza. Przedstawiono przypadek rozległego ziarniniakowatego zapalenia stercza u 61-letniego pacjenta, które wystąpiło po pierwszym kursie dobrze tolerowanej terapii Bacillus Calmette-Guérin. Z powodu nieprawidłowego badania per rectum oraz obrazu stercza w USG przezodbytniczym z rozległym naciekiem naśladującym rozrost nowotworowy wykonano biopsję rdzeniową stercza. Badanie histopatologiczne ujawniło nacieki zapalne pochodzenia gruźliczego.

Discipline

Year

Volume

16

Issue

67

Pages

404–410

Physical description

Contributors

  • Department of Urology, 1st Military Hospital, Lublin, Poland. Department of General and Transplant Surgery and Nutritional Treatment, Medical University of Lublin, Poland
  • Department of General and Transplant Surgery and Nutritional Treatment, Medical University of Lublin, Poland
  • Department of Urology, Railway Hospital in Lublin, Poland
author
  • Department of Clinical Pathomorphology, Medical University of Lublin, Poland

References

  • 1. Heidenreich A, Bastian PJ, Bellmunt J, Bolla M, Joniau S, van der Kwast T et al.; European Association of Urology: EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intent-update 2013. Eur Urol 2014; 65: 124–137.
  • 2. Koya MP, Simon MA, Soloway MS: Complications of intravesical therapy for urothelial cancer of the bladder. J Urol 2006; 175: 2004–2010.
  • 3. Leibovici D, Zisman A, Chen-Levyi Z, Cypele H, Siegel YI, Faitelovich S et al.: Elevated prostate specific antigen serum levels after intravesical instillation of bacillus Calmette-Guerin. J Urol 2000; 164: 1546–1549.
  • 4. LaFontaine PD, Middleman BR, Graham SD Jr, Sanders WH: Incidence of granulomatous prostatitis and acid-fast bacilli after intravesical BCG therapy. Urology 1997; 49: 363–366.
  • 5. Joaquim A, Custódio S, Pimentel FL, Matos JF, Peixoto V, Faria AL et al.: Bacillary prostatitis after intravesical immunotherapy: a rare adverse effect. Case Rep Oncol 2012; 5: 80–83.
  • 6. Szopiński T, Nowicki A, Záťura F, Gołąbek T, Chłosta P: Novel trends in transrectal ultrasound imaging of prostate gland carcinoma. J Ultrason 2014; 14: 306–319.

Document Type

report

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.psjd-5ad33403-f2e2-4635-8bd6-4096e9e8b41c
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