Zastosowanie aripiprazolu w leczeniu zaburzeń psychicznych u dzieci i młodzieży

• Authors: Lena Cichoń , Bożena Gabryel , Ireneusz Jelonek , Krzysztof Krysta , Małgorzata Janas-Kozik

Title variants

EN

The use of aripiprazole in the treatment of mental disorders in children and adolescents

• Languages of publication: PL EN

Abstracts

PL

Artykuł dotyczy aripiprazolu – atypowego leku przeciwpsychotycznego, który w Polsce jest zarejestrowany w terapii schizofrenii u osób w wieku ≥15 lat oraz epizodów maniakalnych o nasileniu umiarkowanym do ciężkiego w przebiegu zaburzenia afektywnego dwubiegunowego typu I u młodzieży w wieku ≥13 lat w leczeniu trwającym do 12 tygodni. Omówiono mechanizm działania, farmakokinetykę oraz bezpieczeństwo stosowania aripiprazolu w populacji dzieci i młodzieży. Aripiprazol działa jako częściowy agonista receptora dopaminowego D2 i serotoninowego 5HT1A. Farmakokinetyka aripiprazolu u ludzi jest liniowa i proporcjonalna do dawki w zakresie 5–30 mg. U dzieci i młodzieży w wieku 10–17 lat profil farmakokinetyczny leku jest porównywalny do obserwowanego u osób dorosłych, po korekcie różnic w masie ciała. Artykuł zawiera także przegląd badań dotyczących skuteczności klinicznej aripiprazolu w leczeniu zaburzeń psychiatrycznych, tj. schizofrenii, zaburzeń afektywnych dwubiegunowych, zaburzeń hiperkinetycznych, całościowych zaburzeń rozwojowych, tików oraz zachowań agresywnych u dzieci i młodzieży. W próbach klinicznych populacji pediatrycznej lek wykazuje dobry profil bezpieczeństwa i tolerancji. Częstość występowania i rodzaj działań niepożądanych aripiprazolu wśród dzieci i młodzieży są zasadniczo podobne jak w przypadku osób dorosłych. Jednak u młodzieży leczonej aripiprazolem mogą częściej niż u dorosłych pojawiać się efekty uboczne, takie jak senność, sedacja, objawy pozapiramidowe, suchość w jamie ustnej, wzrost apetytu i niedociśnienie ortostatyczne. Wydaje się, że aripiprazol z powodu swojego korzystniejszego profilu metabolicznego może odgrywać istotną rolę wleczeniu zaburzeń psychiatrycznych u dzieci i młodzieży.

EN

The article is about aripiprazole – an atypical antipsychotic that is registered in Poland for the treatment of schizophrenia in individuals aged ≥15 years, and moderate to severe manic episodes in the course of bipolar disorder type I in adolescents aged ≥13 years in the treatment lasting up to 12 weeks. The paper discusses the mechanism of action, pharmacokinetics, and safety of aripiprazole in the paediatric population. Aripiprazole acts as a partial agonist of the dopamine D2 receptor and the serotonin 5HT1A receptor. Aripiprazole pharmacokinetics in humans is linear and proportional to the dose range of 5–30 mg. In children and adolescents aged 10–17 years, the pharmacokinetic profile is comparable to that observed in adults, after the adjustment for body weight. The article also contains a review of research on the clinical efficacy of aripiprazole in the treatment of psychiatric disorders, such as: schizophrenia, bipolar disorder, hyperkinetic disorder, pervasive developmental disorders, tics and aggressive behaviours in children and adolescents. Aripiprazole evaluated in clinical trials among children and adolescents has shown a good safety and tolerability profile. The incidence and type of side effects of aripiprazole in the paediatric population are essentially similar to those observed in adults. However, by contrast with adults, adolescents treated with aripiprazole may more often develop such side effects as drowsiness, sedation, extrapyramidal symptoms, dry mouth, increased appetite, and orthostatic hypotension. Aripiprazole may play an important role in the treatment of psychiatric disorders in children and adolescents because of its favourable metabolic profile.

Keywords

EN

aripiprazol; atypowy neuroleptyk; dzieci; farmakokinetyka; farmakologia

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Psychiatria i Psychologia Kliniczna
• Year: 2018
• Volume: 18
• Issue: 4
• Pages: 373–387

Contributors

author

Lena Cichoń

• Oddział Kliniczny Psychiatrii iPsychoterapii Wieku Rozwojowego, Centrum Pediatrii im. Jana Pawła II w Sosnowcu Sp. zo.o., Sosnowiec, Polska

author

Bożena Gabryel

• Zakład Farmakologii, Katedra Farmakologii, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska

author

Ireneusz Jelonek

• Oddział Kliniczny Psychiatrii i Psychoterapii Wieku Rozwojowego, Centrum Pediatrii im. Jana Pawła II w Sosnowcu Sp. z o.o., Sosnowiec, Polska

author

Krzysztof Krysta

• Katedra Psychiatrii i Psychoterapii, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska; Klinika Rehabilitacji Psychiatrycznej, Wydział Lekarski w Katowicach, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska

author

Małgorzata Janas-Kozik

• Oddział Kliniczny Psychiatrii i Psychoterapii Wieku Rozwojowego, Centrum Pediatrii im. Jana Pawła II w Sosnowcu Sp. z o.o., Sosnowiec, Polska; Katedra Psychiatrii iPsychoterapii, Śląski Uniwersytet Medyczny w Katowicach, Katowice, Polska

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• Document Type: article