Involvement of Free Radicals in the Ageing of Cutaneous Membrane

• Authors: Babatunde Oluwafemi Adetuyi , Peace Funmilayo Adebayo , Peace Abiodun Olajide , Olusegun Oladimeji Atanda , Julius Kola Oloke
• Languages of publication: EN

Abstracts

EN

The free radical theory of aging suggests that aging is caused by accumulation of damage inflicted by reactive oxygen species (ROS). However, this concept has been very useful in defining the contribution of oxidative damage to the aging process, an increasing number of studies opposes it. The idea that oxidative damage represents only one of many causes of aging also has limitations, as it does not explain causal relationships and inevitability of damage accumulation. Here, it is discussed that heterogeneity, infidelity and imperfectness of each and every biological process may be responsible for the inevitable accumulation of by-products and other damage forms. Although ROS are prototypical by-products, their contribution to aging is governed by the metabolic organization of the cell, its protective systems, and genotype. These factors are controlled by natural selection, dietary and genetic interventions that extend lifespan, change the composition of cumulative damage and the rates of accumulation of its various forms. Oxidative damage, like other specific damage types viewed in isolation or in combination, does not represent the cause of aging. Instead, biological imperfectness, which leads to inevitable accumulation of damage in the form of mildly deleterious molecular species, may help define the true root of aging. Free radical and other specialized damage theories served their purpose in the understanding of the aging process, but in the current form they limit further progress in this area.

Keywords

EN

Ageing; Antioxidant; Cutaneous membrane; Free radicals; Reactive oxygen specie (ROS)

Discipline

• MEDICAL_BIOLOGY: MEDICAL BIOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2022
• Volume: 43
• Pages: 11-37

Contributors

author

Babatunde Oluwafemi Adetuyi

• Biochemistry Unit, Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

author

Peace Funmilayo Adebayo

• Biochemistry Unit, Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

author

Peace Abiodun Olajide

• Biochemistry Unit, Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

author

Olusegun Oladimeji Atanda

• Microbiology Unit, Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

author

Julius Kola Oloke

• Microbiology Unit, Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

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• Document Type: article