PL EN


Preferences help
enabled [disable] Abstract
Number of results
2019 | 117 | 212-220
Article title

Synthesis characterization and antimicrobial activity of ethyl-4-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate

Content
Title variants
Languages of publication
EN
Abstracts
EN
Heteroatoms like nitrogen, sulfur, and oxygen containing biologically active ethyl 4-(2,4-dichlorophenyl)-1,2,3,4-tetrahydro-6-methyl-2-thioxopyrimidine-5-carboxylate was synthesized from 2,4-dichloro benzaldehyde, acetoacetic ester and thiourea using AlTiTUD-1 as a catalyst. The synthesized compound was characterized by FT-IR, 1H and 13C NMR spectral values. The compound possesses good antimicrobial activity is determined by well diffusion method against gram positive, gram negative and fungal species. The minimum inhibitory concentration value of the compound was determined by broth dilution method.
Keywords
Year
Volume
117
Pages
212-220
Physical description
Contributors
author
  • PG & Research Department of Chemistry, Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India
author
  • Government Arts College, C. Mutlur, Chidambaram, Tamil Nadu, India
References
  • [1] M. Koca, S. Servi, C. Kirilmis, M. Ahmedzade, C. Kazaz, B. Ozbek, G. Otuk. Eur. J. Med. Chem. 40 (2005) 1351.
  • [2] K.M. Ghoneim, R. Youssef, J Indian Chem Soc. 53 (1986) 914.
  • [3] N. Zhang, S. Ayral-Kaloustian, T. Nguyen, R. Hernandezb, C. Beyerb, Chem Lett 17 (2007) 3003.
  • [4] N.R. Mohamed, M.M. Talaat El-Saidi, Y.M. Alia, M.H. Elnagdi, Bioorg Med Chem. 15 (2007) 6227.
  • [5] E.M. Rakib, S. Abouricha, A. Hannioui, N. Benchat, L. Ait M'barek, A. Zyad, J Iranian Chem Soc. 3 (3) (2006) 272.
  • [6] P.G. Baraldi, M.G. Pavani, M. Nunez, et al., Med Chem Lett. 10 (2002) 449.
  • [7] A.M. Kamela, B. Munsonb, J Ame Soc Mass Spectr. 18 (2007) 1477.
  • [8] N. Zhang, S. Ayral-Kaloustian, T. Nguyen et al., J Med Chem. 50 (2007) 319.
  • [9] O. Prakash, R. Kumar, R. Kumar, P. Tyagi, R.C. Kuhad, Euro J Med Chem. 42 (2007) 868.
  • [10] S.M. Sondhi, S. Jain, M. Dinodia, R. Shuklab, R. Raghubir, Bioorg Med Chem. 15 (2007) 3334.
  • [11] P. Molina, E. Aller, A. Lorenzo, et al., J Med Chem. 44 (2001) 1011.
  • [12] S.S. Bahekar, D.B. Shinde, Acta Pharm. 53 (2003) 223.
  • [13] S.M. Sondhi, M. Johar, S. Rajvanshi, et al., Aust J Chem. 54 (2001) 69.
  • [14] M.C. Lanier, M. Feher, N.J. Ashweek, et al., Bioorg Med Chem. 15 (2007) 5590.
  • [15] F.A. Eid, A.F.A. El-Wahab, G.A.M. El-Hag Ali, M.M. Khafagy, Acta Pharm. 54 (2004) 13.
  • [16] L. Xiaoling, G. Mei-Lin, Bioorg Med Chem. 14 (2006) 153.
  • [17] O. Bruno, C. Brullo, S. Schenone, et al., Med Chem. 14 (2006) 121.
  • [18] Appelbaum and Hunter, P.C. Appelbaum, P.A. Hunter, Int. J. Antimicrob. Agents. 16 (2000) 5.
  • [19] Andriole, V.T. AndrioleIn, Current Clinical Topics in Infectious Diseases Blackwell Sciences. (1998) p. 19.
  • [20] Frere, J.M. Frere, Mol. Microbiol. 16 (1995) 385.
  • [21] Sondhi MS, Jain S, Dinodia M, Shukla R, Raghubir R, Bioorg Med Chem. 2007, 15(10) 3334-44.
  • [22] Bruno O, Brullo C, Schenone S, Francesco B, Ranise A, Massimiliano T et al., Bioorg Med Chem. 2004, 12(3), 553-561.
  • [23] Alagarsamy V, Meena S, Ramseshu KV, Solomon VR, Thirumurugan K, Dhanabal K, Eur J Med Chem. 41(11) (2006) 1293-1300.
  • [24] Zhou JP, Ding YW, Zhang HB, Xu L, Dai Y. Chin, Chem Lett 2008, 19(6), 669-672.
  • [25] Keri RS, Hosamani KM, Shingalapur RV, Hugar MH, Eur J Med Chem. 2010, 45(6), 2597-605.
  • [26] Devesa I, Alcaraz JM, Riguera R, Ferrandiz ML, Eur J Pharmacol 2004, 488(1-3): 225-230.
  • [27] Shaaban MR, Saleh TS, Mayhoub AS, Mansour A. Farag AM, Eur J Med Chem. 2008, 16(12), 6344-6352.
  • [28] Antre RV, Kumar AC, Goli D, Andhale GS, Oswal RJ, Saudi Pharm J 2011, 19(4), 233-243.
  • [29] Mohamed MS, Awad SM, Sayed AI. Molecules. 2010, 15(3), 1882-1890.
  • [30] Vaghasia SJ, Shah VH. Microwave assisted synthesis and antimicrobial activity of novel pyrimidine derivatives, J Serb Chem Soc. 2007, 72(2), 109-117.
  • [31] Salahuddin Md, Singh S, Shantakumar SM. Rasayan J Chem. 2009, 2(1), 167-73.
  • [32] Deshmukh MB, Salunkhe SM, Patil DR, Anbhule, Eur J Med Chem. 2009, 44(6), 2651-2654.
  • [33] Bekhit AA, Fahmy HTY, Rostom SAF, Baraka AM, Eur J Med Chem. 2002, 38(1), 27-36.
  • [34] Naik TA, Chikhalia KH, E J Chem 2007, 4(1), 60-66.
  • [35] G.W. Kenner, A. Todd, Heterocyclic Compounds. R.C. Elderfield (Ed.), Vol. 6, Wiley, New York (1957)
  • [36] D.J. Brown, The Chemistry of Heterocyclic Compounds A. Weissberger (Ed.), vol. 16, Interscience, New York (1962)
  • [37] Lorian, Victor (2005), Antibiotics in Laboratory Medicine. Lippincott Williams & Wilkins, p. 149.
Document Type
short_communication
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-5679bf27-862b-4396-8104-18f32f483651
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.