Plummer Vinson Syndrome (PVS) with parotid gland squamous cell carcinoma in a young female
Languages of publication
Plummer Vinson syndrome also known as Paterson Brown-Kelly syndrome is a syndrome associated with the triad of symptoms comprising microcytic hypochromic anaemia, oesophageal strictures and dysphagia. PVS (Plummer Vinson Syndrome) is commonly found in women of middle age especially in the fourth and fifth decade of life and is rarely reported in males and young females. Symptoms resulting from anaemia predominates the clinical picture, apart from the additional features such as glossitis, angular cheilitis, and dysphagia. Dysphagia is main clinical feature of PVS. PVS carries an increased risk of development of squamous cell carcinoma of oesophagus and pharynx. A classic case report of PVS associated with swelling of the salivary gland with clinical features, oral manifestations, malignant potential, differential diagnosis, investigation, and treatment is discussed here. This article carries a message that oral and pharyngeal manifestations also should be considered to rule out malignancy in PVS & also it increases the risk factor of salivary gland squamous cell carcinoma. Early identification and diagnosis improves the prognosis and better chances of survival. We have to be familiar with the oral manifestations of anaemia and be able to suspect PVS to aid in early diagnosis and prompt treatment. This case study was taken from Medcare hospital, karimnagar, Telangana.
-  Abdul S., Mohan N., Suresh Balaji RV., Dominic A., and Patil SG. Oral manifestations of Plummer-Vinson syndrome: A classic report with literature Review. Journal of International Oral Health, 2015 Mar; 7(3): 68–71.
-  Swain S. K, Panigrahy R., Sahu M. C. Plummer vinson syndrome in a male and his chromosomal study—a case report. Egyptian Journal of Medical Human Genetics 2015; 16(3): 283–286.
-  Ali Solmaz, Osman Bilgin Gulcicek, Talar Vartanoglu,Erkan Yavuz, Hakan Yigitbas, Candas Ercetin, Atilla Celik, Fatih Celebi. Endoscopic management of dysphagia in plummer–vinson syndrome, Bagcilar Medical Bulletin 2017; 2(1): 25-2.
-  Jan Waldenstrom, Sven Roland Kjellberg. The Roentgenological Diagnosis of Sideropenic Dysphagia. Acta Radiologica, 20, 6, (1939) 618-638.
-  Novacek G. Plummer-vinson syndrome. Orphanet Journal of Rare Diseases 2006; 1(1): 1750-1172.
-  Demirci F., Savaş M. C., Kepkep N., et al. Plummer-vinson syndrome and dilation therapy: a report of two cases. Turkish Journal of Gastroenterology 2005; 16(4): 224–227.
-  Naik S. M., Shivakumar M. C., Appaji M. K., Ravishankara S., Naik S. S., de Souza C. A case of plummer-vinson syndrome esophageal web dysphagia treated by dilatation with cuffed endotracheal tube. International Journal of Head and Neck Surgery 2011; 2(3): 161–165.
-  Shreedevi S Bobati, B V Patil and V D Dombale. Histopathological study of salivary gland tumors. J Oral Maxillofac Pathol. 2017 Jan-Apr; 21(1): 46–50.
-  Hasan S., Khan N. I., Siddiqui A. Plummer Vinson Syndrome-A premalignant condition-an overview of literature. Journal of Medical and Dental Sciences 2013; 1(1): 28–30.
-  Ivica Lukšić, Mišo Virag, Spomenka Manojlović, Darko Macan. Salivary gland tumours: 25 years of experience from a single institution in Croatia. Journal of Cranio- Maxillofacial Surgery, 2012; 40(3): 75-81.
-  Vittal K., Pandian S. S., Malarkodi T. Plummer – Vinson Syndrome: a case report and medical management. IJSS Case Reports & Reviews 2015; 2(6): 10–13.
-  Bakshi SS and Satvinder Singh. Plummer Vinson Syndrome - is it common in males? Arquivos de Gastroenterologia, 2015; 52(3): 250-252
-  Lawoyin D., Reid E., Sam F., Obayomi T., Bonnick A. Plummer Vinson Syndrome: a case report and literature review. The Internet Journal of Dental Science. 2006; 5(2).
-  Priyadarshini Karthikeyan, Nalini Aswath and Ramesh Kumaresan. Plummer Vinson Syndrome: A Rare Syndrome in Male with Review of the Literature. Case Reports in Dentistry, 2017. https://doi.org/10.1155/2017/6205925
-  Lynch TJ et al. Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib. New England Journal of Medicine, 2004 May 20; 350(21): 2129-39.
Publication order reference