Synthesis, Antimicrobial and Antioxidant Activities of Some Naphthalene - Containing Hydrazone Derivatives

• Authors: S. Sivasankari , M. Rubala mary
• Languages of publication: EN

Abstracts

EN

The inevitable consequence of the widespread use of antimicrobial agents has been the emergence of antibiotic resistant pathogens, functioning an ever- increasing used for new drugs. In an effort to develop antimicrobial agents a series of hydrazones derivative 2-6 were synthesized. The synthesized hydrazones were characterized on the basis physical and spectroscopic data and were evaluated for their antimicrobial activity against various bacterial and fungal strains using disc diffusion method using nutrient agar media. In addition, the antioxidant activities of the products were evaluated. Our data showed that many derivatives have promising activities as antioxidant agents.

Keywords

EN

antibiotic   antimicrobial activities   antioxidant activities   hydrazone   naphthalene  

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2018
• Volume: 18
• Issue: 2
• Pages: 124-132

References

• [1] March, Jerry (1985), Advanced Organic Chemistry: Reactions, Mechanisms, and Structure (3rd ed.), New York: Wiley, ISBN 0-471-85472-7
• [2] Stork, G.; Benaim, J. (1977), Monoalkylation of α,β-Unsaturated Ketones via Metalloenamines: 1-butyl-10-methyl-Δ1(9)-2-octalone, Org. Synth. 57: 69, Coll. Vol. 6: 242
• [3] Day, A. C.; Whiting, M. C. (1970), Acetone hydrazone, Org. Synth. 50: 3, Coll. Vol. 6: 10
• [4] Sevim Rollas and S. Guniz Kucukguzel, Molecules 2007, 12, 1910-1939.
• [5] V. Singh, V. K. Srivastava, G. Palit, K. Shanker, Arzneim-Forsch. Drug. Res. 1992, 42, 993-996.
• [6] Vicini, P.; Zani, F.; Cozzini, P.; Doytchinova, I.; Eur. J. Med. Chem. 2002, 37, 553.
• [7] Kocyigit-Kaymakcioglu, B.; Rollas, S.; Farmaco 2002, 57, 595.
• [8] Ragavendran, J. V.; Sriram, D.; Patel, S. K.; Reddy, I. V.; Bharathwajan, N.; Stables, J.; Yogeeswari, P.; Eur. J. Med. Chem. 2007, 42, 146.
• [9] Bezerra-Netto, H. J. C.; Lacerda, D. I.; Miranda, A. L. P.; Alves, H. M.; Barreiro, E. J.; Fraga, C. A. M.; Bioorg. Med. Chem. 2006, 4, 7924.
• [10] Avaji, P. G.; Kumar, C. H. V.; Patil, S. A.; Shivananda, K. N.; Nagaraju, C.; Eur. J. Med. Chem. 2009, 44, 3552.
• [11] Kümmerle, A. E.; Raimundo, J. M.; Leal, C. M.; Da Silva, G. S.; Balliano, T. L.; Pereira, M. A.; De Simone, C. A.; Sudo, R. T.; Zapata-Sudo, G.; Fraga, C. A. M.; Barreiro, E. J.; Eur. J. Med. Chem. 2009, 44, 4004.
• [12] Coelho, P. M. Z.; Pereira, L. H.; Rev. Inst. Med. Trop. São Paulo 1991, 33, 50.
• [13] Romeiro, N. C.; Aguirre, G.; Hernández, P.; González, M.; Cerecetto, H.; Aldana, I.; Pérez-Silanes, S.; Monge, A.; Barreiro, E. J.; Lima, L. M.; Bioorg. Med. Chem. 2009, 17, 641.
• [14] Stadler, A.; Harrowfield, J.; Inorg. Chim. Acta 2009, 362, 4298.
• [15] Pinto, J. J.; Moreno, C.; García-Vargas, M.; Talanta 2004, 64, 562.
• [16] Terra, L. H. S. A.; Guekezian, M.; Gaubeur, I.; Matos, J. R.; Suárez-Iha, M. E. V.; Polyhedron 2002, 21, 2375.
• [17] Pouralimardan, O.; Chamayou, A. C.; Janiak, C.; Hosseini-Monfared, H.; Inorg. Chim. Acta 2007, 360, 1599.
• [18] Basu, C.; Chowdhury, S.; Banerjee, R.; Evans, H. S.; Mukherjee, S.; Polyhedron 2007, 26, 3617.
• [19] Bakir, M.; Green, O.; Mulder, W. H.; J. Mol. Struct. 2008, 17, 873.
• [20] Bacchi, A.; Carcelli, M.; Pelagatti, P.; Pelizzi, C.; Pelizzi, G.; Zani, F.; J. Inorg. Biochem. 1999, 9, 133.
• [21] Carcelli, M.; Mazza, P.; Pelizi, C.; Zani, F.; J. Inorg. Biochem. 1995, 57, 43.
• [22] Banerjee, S.; Mondal, S.; Chakraborty, W.; Sem, S.; Gachhui, R.; Butcher, R. J.; Slawin, A. M. Z.; Mandal, C.; Mitra, S.; Polyhedron 2009, 28, 2785.
• [23] Johnson, D. K.; Murphy, T. B.; Rose, N. J.; Goodwin, W. H.; Pickart, L.; Inorg. Chim. Acta 1982, 67, 159.
• [24] National Committee for Clinical Laboratory Standards (NCCLS), Approved Standard Document M-7A, Villanova, P.A., 1985
• [25] K. Kato, S. Terao, N. Shimamoto and M. Hirata, Studies on Scavengers of Active Oxygen Species. 1. Synthesis and Biological Activity of 2-O Alkylascorbic Acids, Journal of Medicinal Chemistry, Vol. 31, No. 4, 1988, pp. 793-798. doi:10.1021/jm00399a019

• Document Type: article