CHARACTERISATION AND DISSOLUTION PROPERTIES OF KETOPROFEN IN BINARY SOLID DISPERSION WITH CHITOSAN

• Authors: Bożena Grimling , Agata Górniak , Jan Meler , Maria Szcześniak
• Languages of publication: EN EN

Abstracts

EN

BCS class II includes drugs with low solubility and high permeability. Ketoprofen is an example of this class of drugs. The aim of the study was to investigate the effect of chitosan with average molecular weights in various formulations on the dissolution of ketoprofen incorporated into this polymer carrier. The study investigated ketoprofen in solid dispersions using a method of the solvent evaporations at the drug to polymer ratios of 1:9. 3:7, and 5:5. The highest dissolution of fenofibrate, amounting to 98.8%, was observed after 60 minutes from solid dispersions with a drug-polymer weight ratio 1:9 in the presence of chitosan B and was 32-times higher in relation to the amount of added polymer in comparison to the solubility of pure drug. DSC and IR investigations showed that ketoprofen remained in its crystalline state in solid dispersion. There was no change in the chemical structure of the drug after the incorporation of the drug onto the polymer. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.

Keywords

EN

different molecular weights of chitosan; dissolution; ketoprofen; solid dispersion prepared solvent evaporation

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2014
• Volume: 19
• Pages: 23-31

Contributors

author

Bożena Grimling

• Department Inorganic Chemistry Faculty of Pharmacy, The „Silesian Piasts” Memorial Medical University of Wroclaw

author

Agata Górniak

• Department Inorganic Chemistry Faculty of Pharmacy, The „Silesian Piasts” Memorial Medical University of Wroclaw

author

Jan Meler

• Department Inorganic Chemistry Faculty of Pharmacy, The „Silesian Piasts” Memorial Medical University of Wroclaw

author

Maria Szcześniak

• Department Inorganic Chemistry Faculty of Pharmacy, The „Silesian Piasts” Memorial Medical University of Wroclaw

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• Document Type: article