Reaktywność układu odpornościowego w niektórych zaburzeniach psychicznych

• Authors: Elżbieta Kozłowska , Paulina Żelechowska , Tomasz Sobów , Ewa Brzezińska-Błaszczyk

Title variants

EN

The reactivity of the immune system in some psychiatric disorders

• Languages of publication: EN PL

Abstracts

EN

Without any doubt, one of the most important roles of the immune system is protection against various pathogens, including bacteria, viruses, fungi and parasites. Currently, it is well known that any changes in its activity lead to an increase in the frequency of infectious diseases. There are some data available, suggesting that in patients with psychiatric disorders, such as depressive disorder, schizophrenia or bipolar disorder, immune system reactivity is modified. In this review, the activity of some innate immunity elements, such as the number and the cytotoxic activity of NK cells, the activity of the complement system, the number of neutrophils, the activity of monocytes/macrophages, the concentration of reactive oxygen species and reactive nitric species, the concentration of acute phase proteins (e.g. C-reactive proteins, mannose-binding lectin) in patients with mental disorders is presented. Also, cytokine and chemokine concentrations (IL-1β, IL-4, IL-6, IL-8, IL-10, IP-10, MCP-1, TNF, IFN-γ) in patients with psychiatric disorders are discussed. Finally, the alterations in adaptive immunity response, including B cell and T cell subpopulation number, and immunoglobulin levels (IgG, IgM, IgA, IgE) are demonstrated. It should be stressed, however, that data concerning the immune system reactivity in patients with different mental disorders are still scarce and ambiguous. Further studies are needed, therefore, to fully explain the relationship between psychiatric disorders and immune system functioning.

PL

Jednym z najważniejszych zadań układu odpornościowego jest bez wątpienia obrona organizmu przed patogenami, w tym bakteriami, wirusami, grzybami i pasożytami. Jakiekolwiek zmiany aktywności tego układu prowadzą do zwiększenia zapadalności na choroby infekcyjne. Pojawiają się doniesienia, zgodnie z którymi u pacjentów cierpiących na choroby psychiczne, np. depresję, schizofrenię czy chorobę dwubiegunową, reaktywność układu odpornościowego jest zmieniona. W pracy przedstawiono informacje dotyczące wybranych elementów odporności nabytej – liczebności i cytotoksyczności komórek NK, aktywności układu dopełniacza, liczebności neutrofilów, aktywności monocytów/makrofagów, stężenia reaktywnych form tlenu, reaktywnych form azotu i białek ostrej fazy (białka C-reaktywnego, lektyny wiążącej mannozę) – u pacjentów z zaburzeniami psychicznymi. Ponadto zaprezentowano dane na temat stężenia cytokin i chemokin (IL-1β, IL-4, IL-6, IL-8, IL-10, IP-10, MCP-1, TNF, IFN-γ) u tych chorych. Omówiono także zmiany w odpowiedzi nabytej układu odpornościowego, w tym liczebność subpopulacji limfocytów B i limfocytów T oraz poziom immunoglobulin (IgG, IgM, IgA, IgE). Jako że dane z tego zakresu są bardzo nieliczne i niejednoznaczne, należy prowadzić dalsze badania dotyczące zależności między reaktywnością układu odpornościowego a zaburzeniami psychicznymi.

Keywords

EN

immune system; psychiatric disorders; psychoneuroimmunologia; psychoneuroimmunology; układ odpornościowy; zaburzenia psychiczne

Discipline

• MEDICINE: MEDICINE

• Journal: Psychiatria i Psychologia Kliniczna
• Year: 2015
• Volume: 15
• Issue: 4
• Pages: 182–188

Contributors

author

Elżbieta Kozłowska

• Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi, Polska

author

Paulina Żelechowska

• Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi, Polska

author

Tomasz Sobów

• Zakład Psychologii Lekarskiej, Uniwersytet Medyczny w Łodzi, Polska

author

Ewa Brzezińska-Błaszczyk

• Zakład Immunologii Doświadczalnej, Uniwersytet Medyczny w Łodzi, Polska,

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• Document Type: review