Liver injury during long-term Aspirin Treatment After Desensitization (ATAD) in a patient with nonsteroidal anti-inflammatory drugs-exacerbated respiratory disease (N-ERD) – A case report

• Authors: Karolina Frachowicz , Aleksandra Wardzyńska , Anna Sajna , Joanna S. Makowska , Marek L. Kowalski

Title variants

PL

Uszkodzenie wątroby w przebiegu długotrwałego leczenia aspiryną po desensytyzacji u pacjentki z chorobą dróg oddechowych zaostrzaną przez niesteroidowe leki przeciwzapalne - opis przypadku

• Languages of publication: EN PL

Abstracts

EN

We report a case of a 65-year-old woman with respiratory problems increased by N-ERD, who after 9 years of daily intake of 650 mg of aspirin after desensitization experienced a significant liver enzymes elevation, consistent with drug-induced liver injury. Clinical symptoms of liver injury and elevated serum transaminases levels resolved after aspirin intake discontinuation.

PL

W pracy przedstawiono opis przypadku 65-letniej kobiety z chorobą dróg oddechowych zaostrzaną przez NLPZ (N-ERD, astma aspirynowa), u której po dziewięciu latach codziennego przyjmowania aspiryny w dawce 650 mg wystąpił istotny wzrostu stężenia enzymów wątrobowych wskazujący na polekowe uszkodzenie wątroby. Kliniczne i enzymatyczne cechy uszkodzenia wątroby ustąpiły po zaprzestaniu przyjmowania aspiryny.

Keywords

EN

ASA desensitization; N-ERD; aspirin asthma; aspirin treatment after desensitization; drug-induced complications; liver damage; nonsteroidal anti-inflammatory exacerbated respiratory disease

Discipline

• MEDICINE: MEDICINE

• Publisher: Oficyna Wydawnicza Mediton
• Journal: Alergia Astma Immunologia - przegląd kliniczny
• Year: 2019
• Volume: 24
• Issue: 1
• Pages: 30-32

Contributors

author

Karolina Frachowicz

• Immunology and Allergy Clinic, Medical University of Lodz

author

Aleksandra Wardzyńska

• Immunology and Allergy Clinic, Medical University of Lodz

author

Anna Sajna

• Pulmonology Department in Puławy Hospital , Pulmonology, Oncology and Allergology Clinic in Lublin

author

Joanna S. Makowska

• Rheumatology Clinic, Medical University of Lodz

author

Marek L. Kowalski

• Immunology and Allergy Clinic, Medical University of Lodz

References

• Kowalski ML, Agache I, Bavbek S, et al. Diagnosis and management of NSAID-Exacerbated Respiratory Disease (N-ERD)-a EAACI position paper. Allergy 2019; 74: 28-39.
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• Waldram JD, Simon RA. Performing Aspirin Desensitization in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am 2016; 36: 693-703.
• Kowalski ML, Wardzyńska A, Makowska JS. Clinical Trials of Aspirin Treatment After Desensitization in Aspirin-Exacerbated Respiratory Disease. Immunol Allergy Clin North Am 2016; 36: 705-17.
• White AA, Stevenson DD. Aspirin desensitization in aspirin-exacerbated respiratory disease. Immunol Allergy Clin North Am 2013; 33: 211-22.
• Makowska JS, Olszewska-Ziąber A, Bieńkiewicz B, et al. Clinical benefits of aspirin desensitization in patients with nonsteroidal anti-inflammatory drug exacerbated respiratory disease are not related to urinary eicosanoid release and are accompanied with decreased urine creatinine. Allergy Asthma Proc 2016; 37: 216-24.
• Walters KM, Waldram JD, Woessner KM, et al. Long-term Clinical Outcomes of Aspirin Desensitization With Continuous Daily Aspirin Therapy in Aspirin-exacerbated Respiratory Disease. Am J Rhinol Allergy 2018; 32: 280-6.
• Rafeeq A, Najam R, Hussain SJ. Aspirin Associated Liver Toxicity – The Optimal Dose of Aspirin in Liver Insufficiency. International Journal of Scientific Research in Knowledge 2016; 4: 028-032.

• Document Type: article