Bioprospecting of endophytes in medicinal plants for antifungal properties against Candida albicans (C.P.Robin) Berkhout – case study of Mitracarpus scaber Zucc. (Rubiaceae)

• Authors: Aishat Akere , Aisha Muhammad Galallin
• Languages of publication: EN

Abstracts

EN

Endophytic fungi are microorganisms that inhabit the living tissues of their host plants without causing harm to the host plant. They are a promising source of bioactive compounds with antimicrobial properties. This study investigated the antifungal activity of extracts of endophytic fungi (Aspergillus nidulans and Fusarium oxysporum) against Candida albicans conducted at the Department of Plant Science and Biotechnology, Bayero University, Kano, Nigeria. The sample was collected at the Botanical Garden, Bayero University, Kano. The antifungal properties were tested using the agar well diffusion method (1.0 mg/mL, 0.5 mg/mL, 0.25 mg/mL, 0.125 mg/mL, 0.625 mg/mL) for two different solvents, with Fluconazole as the positive control and distilled water as the negative control. The data was collected, and inhibition zones were determined. The result shows a dose-dependent increase in antifungal activity, with the highest inhibition zone observed at 1.0 mg/mL. Statistical analysis was conducted using ANOVA at P< 0.05. There was a significant difference between the concentrations and extracts (P<0.01).

Keywords

EN

Aspergillus; Candida albicans; Dose-dependent Response; Endophytic fungi; Fluconazole; Fusarium; antifungal activity

Discipline

• BIOLOGY: BIOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2025
• Volume: 63
• Issue: 2
• Pages: 193-204

Contributors

author

Aishat Akere

• Department of Plant Science and Biotechnology, Bayero University, Kano, Nigeria

author

Aisha Muhammad Galallin

• Department of Plant Science and Biotechnology, Bayero University, Kano, Nigeria

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• Document Type: article