Właściwości farmakologiczne i zastosowania kliniczne duloksetyny

• Authors: Tomasz Sobów

Title variants

EN

Duloxetine: pharmacologic characteristics and clinical use

• Languages of publication: EN PL

Abstracts

EN

Duloxetine is a drug from the group of selective serotonin-norepinephrine reuptake inhibitors, with a more balanced profile of pharmacological action on the serotonin transporter and the norepinephrine transporter compared to a commonly used venlafaxine. Its efficacy in the treatment of depressive episodes as well as in the prevention of depression relapse has been well documented in clinical trials. Duloxetine seems to be a particularly interesting therapeutic option for patients with depression and accompanying pain and/or anxiety symptoms. Moreover, its efficacy has been also assessed in elderly population. Apart from depression, duloxetine may also be used in the treatment of generalized anxiety disorder and beyond psychiatry – in the treatment of some pain disorders, painful diabetic neuropathy in particular. Although other indications have also been examined (including fibromyalgia, chronic low back pain, chronic pain related to osteoarthritis and stress incontinence), they have not been registered in Poland. The use of duloxetine does not require any special safety measures, with the exception of patients with alcohol-related liver disease (or any other hepatic damage), patients treated for arterial hypertension and those treated with drugs affecting haemostasis.

PL

Duloksetyna jest lekiem z grupy selektywnych inhibitorów wychwytu zwrotnego serotoniny i noradrenaliny o bardziej zrównoważonym profilu farmakologicznego oddziaływania na transporter serotoninowy i noradrenergiczny niż powszechnie stosowana wenlafaksyna. W badaniach klinicznych udokumentowano jej skuteczność w leczeniu epizodów oraz zapobieganiu nawrotom depresji. Duloksetyna jest szczególnie interesującą opcją terapeutyczną u chorych depresyjnych z towarzyszącymi objawami bólowymi oraz lękowymi, została również przebadana w populacji chorych w wieku podeszłym. Poza leczeniem depresji lek może być stosowany w leczeniu uogólnionego zaburzenia lękowego, a poza psychiatrią także w leczeniu niektórych zaburzeń bólowych, zwłaszcza bolesnej neuropatii cukrzycowej. Choć w badaniach klinicznych weryfikowano kilka innych wskazań (takich jak fibromialgia, przewlekłe bóle pleców, bóle w przebiegu osteoarthritis czy wysiłkowe nietrzymanie moczu), nie mają one w Polsce statusu zarejestrowanych. Stosowanie duloksetyny nie wymaga podejmowania szczególnych środków ostrożności, z wyjątkiem pacjentów z chorobą alkoholową (lub innym uszkodzeniem wątroby), osób leczonych z powodu nadciśnienia tętniczego oraz chorych przyjmujących leki wpływające na hemostazę.

Keywords

EN

SNRI; depresja; depression; diabetic neuropathy; duloksetyna; duloxetine; generalized anxiety; lęk uogólniony; neuropatia cukrzycowa

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Communications
• Journal: Psychiatria i Psychologia Kliniczna
• Year: 2015
• Volume: 15
• Issue: 4
• Pages: 195–201

Contributors

author

Tomasz Sobów

• Zakład Psychologii Lekarskiej, Uniwersytet Medyczny w Łodzi oraz Oddział Psychogeriatrii Centralnego Szpitala Klinicznego Uniwersytetu Medycznego w Łodzi, Polska

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• Document Type: review