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2021 | 26 | 162-169

Article title

INFLUENCE OF PECTIN AND CHITOSAN ON THE PROPERTIES OF GELS PROTECTING THE OESOPHAGEAL MUCOSA

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Languages of publication

EN

Abstracts

EN
Among the diseases of the digestive tract, gastro-oesophageal reflux is one of the most troublesome ailments. It is estimated that in highly developed countries, reflux symptoms occur in about 5%-10% of people every day. It has also been found that about 20% of people experience such symptoms once a week. The incidence of this disease increases with age, regardless of gender. The aim of the study was to investigate the physicochemical properties of gels intended for the protection of the oesophageal mucosa. Preparations containing 3.0% pectin showed the lowest pH. These gels can be used in the treatment of advanced alkaline reflux. The addition of chitosan to all tested gels increased their pH and dynamic viscosity. The texture tests showed the effect of pectin concentration on the adhesion work of the tested gels.

Year

Volume

26

Pages

162-169

Physical description

Contributors

  • Department of Drugs Form Technology, Faculty of Pharmacy The “Silesian Piasts” memorial Wroclaw Medical University,

References

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  • Banks M.; (2009) The modern investigation and management of gastro-oesophageal reflux disease (GERD). Clinical Medicine 1, 18–27.
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  • Katz P.O., Gerson L.B., Vela M.F.; (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am. J. of Gastroenterology 108, 308-328. DOI:10.1038/ajg.2012.444.
  • Numans M.E., Lau J., de Wit N.J., Bonis P.A.; (2004) Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Annals of Internal Medicine 7, 518–527.
  • Singh M., Lee J., Gupta N., Gaddam S., Smith B.K., Wani S.B.; (2013) Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity Silver Spring 21, 284–290. DOI: 10.1002/oby.20279.
  • Jacobson B.C., Somers S.C., Fuchs C.S., Kelly C.P., Camargo C.A.J.; (2006) Body- Mass Index and Symptoms of Gastroesophageal Reflux in Women. N Engl J Med 354, 2340–2348.
  • Ze E.Y., Kim B.J., Kang H., Kim J.G.; (2017) Abdominal Visceral to Subcutaneous Adipose Tissue Ratio Is Associated with Increased Risk of Erosive Esophagitis. Dig Dis Sci. 62, 1265–1271. DOI: 10.1007/s10620-017-4467-4.
  • Gao F., Gao Y., Chen X., Qian J., Zhang J.; (2017) Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients. BMC Gastroenterol 67, 1–7. DOI: 10.1186/s12876-017-0624-7
  • Małolepsza-Jarmołowska K.; (2019) Influence of chitosan on the properties of gels protecting of the esophageal mucosa „Progress on Chemistry and Application of Chitin and Its Derivatives“ 24, 135–144 vol. XXIV, ed. by M. Jaworska DOI:10.15259/PCACD.24.012

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article

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bwmeta1.element.psjd-4c99c902-83e3-4c66-af6d-24d80f91712f
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