Terapia bewacizumabem w raku jajnika – przegląd badań klinicznych

• Authors: Jolanta Lubin , Anna Markowska , Janina Markowska

Title variants

EN

Treatment with bevacizumab in ovarian cancer – clinical trials review

• Languages of publication: EN

Abstracts

EN

Angiogenesis is a process which has been in the focus in the last decade due to its role in the development of can­cers. The identification of vascular endothelial growth factor (VEGF) in the beginning of the 80’s became the new objective of therapies of cancers. The finding of angiogenesis inhibitors has brought the therapy of cancers includ­ing ovarian cancer in a new era. Apart from the “golden standard” such as the taxans and platinum components, the treatment of ovarian cancer has not introduced any new front-line drugs for many years. The registration of bevacizumab has changed data regarding in particular the progression-free survival (PFS), which was confirmed by GOG-0218 and ICON-7 clinical trials. The aim of the article was to put clinical trials that pointed to the effi­ciency of bevacizumab in order as well as presenting those whose results may allow in the nearest future for a wider use of bevacizumab – not only in the front-line chemotherapy of ovarian cancer, but also in neoadjuvant therapy and the treatment of a recurrent neoplasm, both platinum-sensitive and platinum-resistant. Studies of predictive factors, which allow for a group of patients who benefit most from anti-angiogenic drugs treatment to be singled out, are also important. At present, clinical trials and scientific studies are under way and maybe they will help identify patients whose PFS and the overall survival (OS) time is be prolonged as a result of treatment with bevacizumab.

PL

Angiogeneza to proces, na którym w ciągu ostatnich dekad skupiono szczególną uwagę, ponieważ odgrywa on istotną rolę w rozwoju nowotworów. Identyfikacja czynnika wzrostu śródbłonka naczyniowego VEGF (vascular endothelial growth factor) na początku lat 80. ubiegłego stulecia stała się niewątpliwie nowym celem terapii nowo­tworów, a stworzenie leków hamujących angiogenezę umożliwiło wprowadzenie leczenia nowotworów, w tym raka jajnika, w nową erę. Od wielu lat w terapii tego nowotworu, oprócz „złotego standardu”, jakim jest stosowanie tak­sanów i pochodnych platyny, nie wdrożono nowych leków w pierwszej linii leczenia. Rejestracja bewacizumabu zmieniła dane dotyczące szczególnie czasu wolnego do progresji (progression-free survival, PFS), co potwierdziły badania rejestracyjne tego preparatu (GOG-0218 i ICON-7). Celem pracy było usystematyzowanie badań klinicz­nych, które dowiodły skuteczności bewacizumabu, a także przedstawienie tych, których wyniki w najbliższej przy­szłości mogą pozwolić na szersze zastosowanie leku – nie tylko w terapii pierwszej linii chemioterapii raka jajnika, ale także w terapii neoadiuwantowej oraz w leczeniu wznowy raka jajnika zarówno u pacjentek z nowotworem platynowrażliwym, jak i platynoopornym. Dużej uwagi wymagają też badania nad czynnikami predykcyjnymi, umożliwiającymi wyłonienie grupy pacjentów, którzy mogą uzyskać największą korzyść z leczenia lekami antyangio­gennymi. Obecnie trwają badania naukowe i kliniczne, które być może pozwolą zidentyfikować chorych, u których terapia bewacizumabem wydłuży PFS i czas całkowitego przeżycia (overall survival, OS).

Keywords

EN

angiogenesis; angiogeneza; badania kliniczne; bevacizumab; bewacizumab; clinical trials; ovarian cancer; rak jajnika

Discipline

• MEDICINE: MEDICINE

• Journal: Current Gynecologic Oncology
• Year: 2013
• Volume: 11
• Issue: 4
• Pages: 286–294

Contributors

author

Jolanta Lubin

• Klinika Onkologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu. Kierownik: prof. dr hab. n. med. Janina Markowska,

author

Anna Markowska

• Klinika Perinatologii i Chorób Kobiecych, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu. Kierownik: prof. dr hab. n. med. Krzysztof Drews

author

Janina Markowska

• Klinika Onkologii, Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu. Kierownik: prof. dr hab. n. med. Janina Markowska

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• Document Type: article