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2013 | 18 | 18 | 167-173
Article title

THE INVESTIGATION OF PHYSICOCHEMICAL PROPERTIES OF THE SOLID DISPERSIONS IN THE PRESENCE POLYMERIC CARRIER- CHITOSAN

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EN
Abstracts
EN
The BCS class II includes drugs with low solubility and high permeability.. Fenofibrate is an example of this class drugs. The aim of the study was to investigate the effect of chitosan on the saturation solubility of fenofibrate incorporated into this polymer carrier. The study investigated fenofibrate in solid dispersions using a method of the solvent evaporation and physical mixtures at the drug to polymer ratio of 1:9,3:7,5:5.Solid dispersion of fenofibrate containing different ratio of medium and high molecular weight chitosan showed high saturation solubility compared to pure sample of drug. IR spectroscopy reveals that there was no chemical interaction between drug and the polymer. DSC studies showed that there is no change in the crystal structure of drug during the solid dispersion technique. Chitosan has been proposed as a useful excipient for enhancing the bioavailability of poorly water-soluble compounds.
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Year
Volume
18
Issue
18
Pages
167-173
Physical description
Contributors
  • Faculty of Pharmacy, "Silesian Piast" memorial Medical University of Wroclaw, bamag@interia.pl
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
References
  • 1. Amidon G.L., Lennernäs H., Shah V.P., Crison J.R..;(1995) A Theoretical Basis for a Biopharmaceutic Drug Classification: The Correlation of in Vitro Drug Product Dissolution and in Vivo Bioavailability. Pharm. Res. 12, pp. 413-420.
  • 2. Yasir M., Asif M., Kumar A., Aggarval A.;(2010) Biopharmaceutical Classification System: An Account; Int. J. of Pharm. Tech. Res. 2, pp. 1681-1690.
  • 3. Vogt M., Kunath K., Dressman J.B.;(2008) Dissolution enhancement of fenofibrate by micronization, cogrinding and spray-drying: Comparison with commercial preparations; Eur. J. of Pharm. and Biopharm. 68, pp.283–288.
  • 5. Guyot M., Fawaz F., Bildet J., Bonini F., Lagueny A.M.;(1995) physicochemical characterization and dissolution of norfloxacin/cyclodextrin inclusion compounds and PEG solid dispersions. Int. J. Pharm. 123, pp.53-63.
  • 6. Patel A.R., Vavia P.R.;(2006) Effect of hydrophilic polymer on solubilization of fenofibrate by cyclodextrin complexation; J. of Inc. Phen.And Macr.Chem. 56, pp. 247-251.
  • 7 Lin, S.-B.; Lin, Y.-C. & Chen, H.-H. (2009) Low molecular weight chitosan prepared with the aid of cellulase, lysozyme and chitinase: Characterisation and antibacterial activity. Food Chem., 116, pp.47-53.
  • 8. Sun, Y.;Cui, F.; Shi, K.; Wang, J.; Niu, M. & Ma, R. (2009). The Effect of Chitosan Molecular Weight on the Characteristics of Spray-Dried Methotrexate-Loaded Chitosan Microspheres for Nasal Administration. Drug Dev. Ind. Pharm., 35, pp. 379-386.
Document Type
article
Publication order reference
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YADDA identifier
bwmeta1.element.psjd-4941ab3a-0006-4d37-aa18-39640eb0560b
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