STUDY OF THE EFFECT OF THE PHYSICOCHEMICAL PROPERTIES OF CHITOSAN ON ITS HAEMOSTATIC ACTIVITY

• Authors: Oksana V. Kadyseva , Vladimir N. Bykov , Olga Y. Strelova , Alexander N. Grebenyuk
• Languages of publication: EN

Abstracts

EN

Chitosan are biopolymers that are actively used for the production of local haemostatic agents. The physicochemical characteristics that determine its biological properties include the molecular weight and the deacetylation degree. However, there is no linear relationship between these parameters and haemostatic activity. The most reliable method of confirming the effectiveness is still in vivo experiments. The ability to initiate haemostasis depends on the conformational transition of chitosan macromolecules. The highest efficiency in vitro was for samples in which the transition of a significant part of the molecules from the ‘rigid rod’ state to the ‘globule’ occurred at physiological pH. It is proposed to expand the list of indicators of chitosan that can be controlled to evaluate the quality of raw materials, related to haemostatic activity, to include the definition of the conformational transition at physiological pH.

Keywords

EN

NMR; UV/Vis spectroscopy.; bleeding; chitosan; conformation; haemostasis

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2021
• Volume: 26
• Pages: 112-120

Contributors

author

Oksana V. Kadyseva

• Department of Pharmaceutical Chemistry, St. Petersburg State Chemical and Pharmaceutical University,

author

Vladimir N. Bykov

• N.Petrov NMRC of Oncology Health Department Russian Federation,

author

Olga Y. Strelova

• Department of Pharmaceutical Chemistry, St. Petersburg State Chemical and Pharmaceutical University,

author

Alexander N. Grebenyuk

• Department of Pharmaceutical Chemistry, St. Petersburg State Chemical and Pharmaceutical University,

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• Document Type: article