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2017 | 15 | 2 | 146–148
Article title

Gestational trophoblastic neoplasia after miscarriage with dilatation and curettage with normal histological findings

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Title variants
PL
Ciążowa neoplazja trofoblastu w następstwie poronienia upacjentki zprawidłowymi wynikami badania histopatologicznego po zabiegu łyżeczkowania jamy macicy
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EN
Abstracts
EN
Gestational trophoblastic neoplasia may develop after a molar, term, ectopic pregnancy, or an abortion. The diagnosis of gestational trophoblastic neoplasia can be made solely based on changes in human chorionic gonadotropin levels without pathologic confirmation. It is important to distinguish molar pregnancy from that disease, as treatment for these entities differs. However, gestational trophoblastic neoplasia developing after a term or ectopic pregnancy, or an abortion may be difficult to diagnose, because there is no tissue confirmation. In such cases, the time between a previous pregnancy event and the current event, and an inconsistency between very high levels of human chorionic gonadotropin and the size of lesions in the uterine cavity may be warning signs of gestational trophoblastic neoplasia. The role of curettage in the treatment of the disease is limited. We present a case of gestational trophoblastic neoplasia that developed after an abortion, serving as a reminder illustration that gestational trophoblastic neoplasia can develop not only after molar pregnancies, but also after other pregnancy events.
Discipline
Publisher

Year
Volume
15
Issue
2
Pages
146–148
Physical description
Contributors
  • Department of Gynecologic Oncology, İzmir Tepecik Research and Training Hospital, İzmir, Turkey, drigulhan@yahoo.com
  • Department of Medical Oncology, İzmir Tepecik Research and Training Hospital, İzmir, Turkey
author
  • Department of Gynecology and Obstetrics, İzmir Tepecik Research and Training Hospital, İzmir, Turkey
  • Department of Gynecologic Oncology, İzmir Tepecik Research and Training Hospital, İzmir, Turkey
  • Department of Gynecologic Oncology, İzmir Tepecik Research and Training Hospital, İzmir, Turkey
  • Department of Gynecologic Oncology, İzmir Tepecik Research and Training Hospital, İzmir, Turkey
References
  • 1. Ngan HYS, Seckl MJ, Berkowitz RS et al.: Update on the diagnosis and management of gestational trophoblastic disease. Int J Gynaecol Obstet 2015; 131 Suppl 2: S123–S126.
  • 2. Ngan HYS, Bender H, Benedet JL et al.; FIGO Committee on Gynecologic Oncology: Gestational trophoblastic neoplasia, FIGO 2000 staging and classification. Int J Gynaecol Obstet 2003; 83 Suppl 1: 175–177.
  • 3. Seckl MJ, Sebire NJ, Fisher RA et al.; ESMO Guidelines Working Group: Gestational trophoblastic disease: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 2013; 24 Suppl 6: vi39–vi50.
  • 4. Stenman UH, Alfthan H: Determination of human chorionic gonadotropin. Best Pract Res Clin Endocrinol Metab 2013; 27: 783–793.
  • 5. Royal College of Obstetricians and Gynaecologists: The Management of Gestational Trophoblastic Disease. RCOG Green–top Guideline No. 38, February 2010.
  • 6. Garner EI, Feltmate CM, Goldstein DP et al.: The curative effect of a second curettage in persistent trophoblastic disease: a retrospective cohort survey. Gynecol Oncol 2005; 99: 3–5.
  • 7. Osborne RJ, Filiaci VL, Schink JC et al.: Second curettage for low-risk nonmetastatic gestational trophoblastic neoplasia. Obstet Gynecol 2016; 128: 535–542.
  • 8. Pezeshki M, Hancock BW, Silcocks P et al.: The role of repeat uterine evacuation in the management of persistent gestational trophoblastic disease. Gynecol Oncol 2004; 95: 423–429.
  • 9. Cole LA: hCG, the wonder of today’s science. Reprod Biol Endocrinol 2012; 10: 24.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-479b20d1-36d1-4350-924e-13871fd21243
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