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2013 | 18 | 18 | 175-179
Article title

STUDIES OF GENTAMYCIN ADSORPTION ON CHITOSAN

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Abstracts
EN
Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind gentamycin. The aim of the study was to determine the binding capability of Gentamycin by chitosan’s contained in weight-loss supplements. The Gentamycin absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of gentamycin by chitosan ranged from 2,1% to 34,1% depending on the environmental pH. The highest absorption rate was observed at above pH 6,8. Concluding, the studies confirmed that the investigated gentamycin interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.
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Volume
18
Issue
18
Pages
175-179
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Contributors
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw, jan.meler@am.wroc.pl
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
author
  • Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw
References
  • 1. Meler J.. Pluta J.. Ulanski P. the and Krotkiewski M. Fat- the binding capacity of ninths - the modified and modified chitosans. In: Progress he Chemistry and Application of Chitin and its Derivatives. Vol. IX (ed.: H. Struszczyk). Polish Chitin Society. Lodz. pp. 129-136. 2003
  • 2. Roberts G.A.F. and Domszy J.G. : Determination of the viscosimetric constants for chitosan. Int. J. Biol. Macromol. 4. 374.1982
  • 3. Mccurdy J.D.- FDA and the use of chitin and chitosan derivative.- In: Advances in Chitin and Chitosan.. Elsevier Applied Science. London. pp. 659-662.1992
  • 4. Meler J. Pluta J and Krotkiewski M. The influence of various kinds of chitosan on fat binding ability .4th World Meeting on Pharmaceutics. Biopharmaceutics and Pharmaceutical Technology. Florence. s. 617-618 2002.
  • 5. Meler J. Pluta J. Ulański P and Krotkiewski M. Vozdejstvie raznych form chitozana na sposobnost' svjazyvanija žirov.Modern perspectives in chitin and chitosan studies : Proceedings of the VIIth International Conference. St. Petersburg - Repino. s. 258-260 Moscow VNIRO Publishing. 2003
  • 6.Jan Meler. Janusz Pluta. Influence on action of enzyme of feed wire in research chitosans in vitro. In : Biomaterials in Regenerative Medicine Vol. 6 (ed.: A. Nadolny) . Polish Academy of Sciences. Vienna pp. 173-177. 2006
  • 7. J.Meler. Influence of different changes on bioavailability of medicine chitosans antiphlogistic drugs. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. XIII (ed.: A. Jaworska). Polish Chitin Society. Łódź. pp. 81-88. 2008
  • 8. J. Meler, J. Pluta. The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical patternelof digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, pp. 131-137, 2004
  • 9.B. Grimling, J. Meler, J. Pluta.: Study of interaction of gastrointestinal agents in the presence of cytoprotective drug including bismuth W: Pierwiastki, środowisko i życie człowieka ; pod red. Kazimierza Pasternaka; Lublin : Polskie Towarzystwo Magnezologiczne, 2009; s.65-74
  • 10. J. Meler, B. Grimling, J. Pluta.: Investigation on adsorption of fatty and bile acids in the presence of dietary supplements containing chromium J.Elementol. 2010 Vol.15 no.1; s.141- 147
  • 11. J. Meler.: Influence of different change on bioavailability of medicine chitosans antiphlogistic drugs Progress on Chemistry and Application of Chitin and Its Derivatives 2008 Vol.13; s.81-88
  • 12.. J. Meler.: The effect of physicochemical factors on absorption properties of certain spasmolytics in the presence of dietary supplements containing chitosan Progress on Chemistry and Application of Chitin and Its Derivatives 2009 Vol.14; s.133-143.
Document Type
article
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bwmeta1.element.psjd-46a6db20-77fa-4880-b0fc-72448274dd6b
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