STUDIES OF GENTAMYCIN ADSORPTION ON CHITOSAN

• Authors: Jan Meler , Bożena Grimling , Janusz Pluta
• Languages of publication: EN

Abstracts

EN

Chitosan as a dietary supplement has been used in the treatment of obesity due to its capability of binding bioactive compounds. A molecule of a cationic polymer, such as chitosan, may bind gentamycin. The aim of the study was to determine the binding capability of Gentamycin by chitosan’s contained in weight-loss supplements. The Gentamycin absorption was investigated by means of a dynamic method in a biopharmaceutical model imitating in vitro conditions including the required level of nutrients. Mean absorption of gentamycin by chitosan ranged from 2,1% to 34,1% depending on the environmental pH. The highest absorption rate was observed at above pH 6,8. Concluding, the studies confirmed that the investigated gentamycin interact with chitosan, what leads to decrease in their amount and affects the bioavailability of the drugs.

Keywords

EN

Gentamycin; adsorption; chitosan

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2013
• Volume: 18
• Issue: 18
• Pages: 175-179

Contributors

author

Jan Meler

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Bożena Grimling

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

author

Janusz Pluta

• Faculty of Pharmacy, "Silesian Piasts" memorial Medical University of Wroclaw

References

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• Document Type: article