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2016 | 54 | 240-251
Article title

Synthesis and in vitro antimicrobial evaluation of some new chalcones containing vinyl ester group and substituted alkyl chain

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EN
Abstracts
EN
A novel series of chalconyl vinyl ester based derivatives were designed and synthesized. The newly synthesized compounds were studied for efficacy against several bacteria (E.Coli, P.Aeruginosa, S.Aureus, S.Pyogenus) and fungi (C.Albicans, A.Niger, Clavatus) using the broth dilution technique. Chalcones were prepared by treatment of 4-iodo acetophenone with 4-hydroxy benzaldehyde by Claisen-Schimidt condensation reaction. Various chalconyl vinyl ester derivatives (C1-C8) were prepared by reaction of chalcone with 4-n-alkoxy cinnamic acids derivatives. Compound C8 shows the best bioactive desired antibacterial analogue with less MIC value against different tested strains. All the final synthesized compounds were characterized by IR, 1H NMR, and elemental analysis.
Year
Volume
54
Pages
240-251
Physical description
References
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Document Type
article
Publication order reference
YADDA identifier
bwmeta1.element.psjd-467c78de-9d80-4288-8241-386e66b70a90
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