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2012 | 39 | 2 | 265-292
Article title

Zaburzenia kaskady transformujących czynnikow wzrostu typu β w wybranych patologiach człowieka

Title variants
Aberrations in the signalling cascade of transforming growth factor β type in selected human pathologies
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A transforming growth factor β type (TGFβ) cascade is a multifactorial signalling pathway, which controls the plethora of cellular processes responsible for human organism homeostasis. The importance of alterations of TGFβ-induced signalling remains unknown. Up till now, impaired TGFβ signalling has been observed in pathologies of the musculoskeletal, cardiovascular and reproductive systems. Abnormalities in the TGFβ pathway can be either genetically determined or appear as spontaneous disorders which emerged during embryonic development. Understanding the role of the TGFβ pathway in the aetiology of various diseases appears to be necessary as it may serve in developing new strategies for therapeutic or diagnostic methods.
Kaskada sygnalizacyjna transformujących czynników wzrostu typu β (TGFβ) stanowi indukowany przez wiele cytokin szlak przekazywania sygnału w komórce, pod kontrolą którego znajduje się szereg procesów komórkowych odpowiedzialnych za prawidłowe funkcjonowanie ludzkiego organizmu. Znaczenie zaburzeń sygnalizacji indukowanej czynnikami TGFβ pozostaje nadal nie do końca poznane. Niemniej jednak już na obecnym etapie badań stwierdzić można ich bezsprzeczny udział w patologiach układu kostno-mięśniowego, układu krwionośnego czy układu rozrodczego.

Physical description
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