CHITOSAN AND CHITOSAN-POLYETHYLENIMINE MICROSPHERES PREPARED BY MEMBRANE EMULSIFICATION AND THEIR APPLICATION FOR DRUG DELIVERY SYSTEMS

• Authors: Joanna Wolska
• Languages of publication: EN

Abstracts

EN

The aim of this paper was to prepare chitosan microspheres characterised by a narrow dispersion of dimensions, suitable for application for drug delivery systems (DDS). The materials, unmodified as well as functionalised using polyethyleneimine were then used for encapsulation of drug-mimicking dyes. The polymeric beads were prepared by one stage process of membrane emulsification. The encapsulation and then evaluation of the release of an active component was carried out using two cytostatics-mimicking dyes: methyl orange and Congo red. The efficiency of encapsulation changed with a type of microspheres and the type of a dye. The highest sorption towards dyes was revealed by PEI-modified chitosan microspheres. Methyl orange was released with the better efficiency than Congo red from all types of microspheres.

Keywords

EN

chitosan; membrane emulsification; microspheres; polyethyleneimine; release; sorption

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2017
• Volume: 22
• Pages: 220 - 235

Contributors

author

Joanna Wolska

• Wroclaw University of Science and Technology, Faculty of Chemistry, Division of Polymer and Carbon Materials, Wybrzeże Wyspiańskiego 27, 50-370 Wroclaw, Poland

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• Document Type: article