CHITOSAN GELS TO PREVENT REFLUX DISEASE

• Authors: Katarzyna Małolepsza-Jarmołowska
• Languages of publication: EN

Abstracts

EN

Reflux disease is one of the most frequently diagnosed conditions in developed countries. The problem is both the acidic content of the stomach and the alkaline content of the intestines. In each case, the oesophageal mucosa is destroyed. I analysed hydrogels that prevent irritation of the oesophageal mucosa. Specifically, I investigated the effect of chitosan and sodium alginate on the properties of gels protecting the oesophagus. Gels containing chitosan and 1.0% sodium alginate can be used to treat advanced alkaline reflux. The addition of chitosan to all the tested gels increased their pH and dynamic viscosity, making it possible to neutralise acid reflux. Texture studies showed the influence of chitosan and sodium alginate on the adhesiveness of the tested gels.

Keywords

EN

alkaline gastro-oesophageal reflux; anti-inflammatory drugs; hydrophilic gels; oesophageal infections; oesophageal mucosa; physiological gastro-oesophageal environment

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Polish Chitin Society
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2023
• Volume: 28
• Pages: 103-110

Contributors

author

Katarzyna Małolepsza-Jarmołowska

• Department of Drug Form Technology, Faculty of Pharmacy, The ‘Silesian Piasts’ Memorial Wroclaw Medical University, Borowska 211A Str., 50–556 Wrocław, Poland

References

• [1] Maret-Ouda J, Markar SR, Lagergren J; (2020) Gastroesophageal reflux disease: a review. JAMA 324 (24), 2536–2547. DOI:10.1001/jama.2020.21360
• [2] Katz PO, Gerson LB, Vela MF; (2013) Guidelines for the diagnosis and management of gastroesophageal reflux disease. Am J Gastroenterol 108, 308–328. DOI:10.1038/ajg.2012.444
• [3] Raban M, Żak A, Litak J, Turska M, Grochowski C; (2017) Gastroesophageal reflux disease – unit description, diagnosis and treatment. J Educ Health Sport 7, 215–225. DOI:10.5281/zenodo.825357
• [4] Vakil N, van Zanten SV, Kahrilas P, Dent J, Jones R; Global Consensus Group; (2006) The Montreal definition and classification of gastroesophageal reflux disease: a global evidence–based consensus. Am J Gastroenterol 101, 1900–1920. DOI:10.1111/j.1572–0241.2006.00630.x
• [5] Numans ME, Lau J, de Wit NJ, Bonis PA; (2004) Short-term treatment with proton-pump inhibitors as a test for gastroesophageal reflux disease: a meta-analysis of diagnostic test characteristics. Ann Intern Med 7, 518–527. DOI:10.7326/0003–4819–140–7-200404060–00011
• [6] Singh M, Lee J, Gupta N, Gaddam S, Smith BK, Wani SB; (2013) Weight loss can lead to resolution of gastroesophageal reflux disease symptoms: a prospective intervention trial. Obesity 21, 284–290. DOI:10.1002/oby.20279
• [7] Jacobson BC, Somers SC, Fuchs CS, Kelly CP, Camargo CAJ; (2006) Body-mass index and symptoms of gastroesophageal reflux in women. N Engl J Med 354, 2340–2348. DOI:10.1056/NEJMoa054391
• [8] Ze EY, Kim BJ, Kang H, Kim JG; (2017) Abdominal visceral to subcutaneous adipose tissue ratio is associated with increased risk of erosive esophagitis. Dig Dis Sci 62, 1265–1271. DOI:10.1007/s10620–017–4467–4
• [9] Gao F, Gao Y, Chen X, Qian J, Zhang J; (2017) Comparison of oesophageal function tests between Chinese non-erosive reflux disease and reflux hypersensitivity patients.BMC Gastroenterol 67, 1–7. DOI:10.1186/s12876–017–0624–7
• [10] Małolepsza-Jarmołowska K; (2019) Influence of chitosan on the properties of gels protecting of the esophageal mucosa. Prog Chem Appl Chitin Deriv 24, 135–144. DOI:10.15259/PCACD.24.012

• Document Type: article