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Journal
2020 | 10 | 2 | 48-51
Article title

Pixantrone – anticancer drug in the monotherapy of aggressive lymphomas

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EN
Abstracts
EN
Pixantrone is a first drug aza-anthracenedione approved as monotherapy of relapsed or refractory aggressive lymphomas. This drug has the unique chemical structure and mode of action properties distinguishing it from anthracyclines and anthracenediones. Pixantrone is one of the treatment option for heavily pretreated patients which to receive their living with doxorubicin and the further application from anthracyclines potentially can lead anthracycline-induced congestive heart failure. The benefit of pixantrone treatment has not been established in patients when used as V line or greater chemotherapy in patients who are refractory to last therapy. In general, pixantrone seems to be safe and manageable. In various trials, there were no unexpected side effects reported and no trials were closed prematurely because of side effects. In an evaluation of 12 clinical trials with pixantrone, the most common side effect (all grades) was hematological toxicity, mainly neutropenia (50% of patients; grade third/fourth: 41%), leukopenia (25%), anemia (31%), and thrombocytopenia (21%). Hematological toxicity was the main reason for a delayed start of subsequent cycles or for omitting the day-15 dose of pixantrone. In the outpatient setting, it is worth considering the use of hematopoietic growth factors. Other side effects included asthenia (23%), pyrexia (23%), and nausea, most patients experienced reversible skin discoloration
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Journal
Year
Volume
10
Issue
2
Pages
48-51
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Contributors
author
  • Clinical Department of Hematology, Warmian-Masurian Cancer Center of The Ministry of The Interior and Administration’s Hospital, Olsztyn, Poland
References
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  • 3. NCBI Bookshelf. A service of the National Library of Medicine, National Institutes of Health.
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  • 5. Jamal-Hanjani M, Pettengell R. Pharmacokinetic evaluation of pixantrone for the treatment of non-Hodgkin’s lymphoma. Expert Opin. Drug Metab Toxicol. 2011; 7(11): 1441-8.
  • 6. Keating GM. Pixantrone: A Review in Relapsed or Refractory Aggressive Non-Hodgkin’s Lymphoma. Drugs. 2016; 76: 1579-86.
  • 7. Lekue CB, Cicala SG, Leppä S. Pixantrone beyond monotherapy: a review. Ann Hematol. 2019; 98: 2025-33.
  • 8. Pixantron – charakterystyka produktu leczniczego.
  • 9. Pettengell R, Coiffi B, Narayanan G et al. Pixantrone dimaleate versus other chemotherapeutic agents as a single-agent salvage treatment in patients with relapsed or refractory aggressive non-Hodgkin lymphoma: a phase 3, multicentre, open-label, randomised trial. Lancet Oncol. 2012; 13: 696-706.
  • 10. Minotti G, Han H, Cattan V et al. Pixantrone: novel mode of action and clinical readouts. Expert Rev Hematol. 2018; 11(7): 587-96.
Document Type
article
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YADDA identifier
bwmeta1.element.psjd-411b4282-e6c7-49e2-9979-e8c90a2805d1
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