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2012 | 17 | 95 - 102
Article title

STUDIES ON ADSORPTION TIAMFENICOL ON CHITOSANS DEGRADED RADIATION IN PHARMACEUTICAL IN VITRO MODEL

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EN
Abstracts
EN
Connections of polymers and biopolymers with biologically active compounds are recently the subject of intensive research. Low molecular weight active ingredient combined with a polymer has, in many cases, the modified action. On the other hand, the use of inappropriate polymers can result in incompatibilities drug-polymer. The phenomenon of adsorption of the antibiotic has been studied by the static method in the concentration range generally taken single dose using a pharmaceutical gastrointestinal tract model. The results of measurements bounded drug quantity were used to determine the average percentage of adsorbed dose. The results show that antibiotic tiamphenicol is adsorbed on chitosan in used pH ranges, and the binding ability depends on the variety of chitosan and directly from the environment reaction. It was observed that the average sorption depending on the type of chitosan was within the limit from 82% to 97%.The fact of the lowest adsorption value at pH 6.4 can be explained by chemical properties of chitosan, which shows the load until the pH > 6.7 and the electrostatic adsorption may be exhibit in relation to weak acid medicinal substance. Thus, the specific polymer surface area and its sorption capacity is increased. Based on the above considerations can be stated that between study drug and the polymer an antagonistic interaction exist by involving the adsorption of drugs from this group on chitosan.
Year
Volume
17
Pages
95 - 102
Physical description
Contributors
author
  • Faculty of Pharmacy, Department of Pharmaceutical Technology Wrocław, Medical University
  • Faculty of Pharmacy, Department of Pharmaceutical Technology Wrocław, Medical University
author
  • Faculty of Pharmacy, Department of Pharmaceutical Technology Wrocław, Medical University
References
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  • Torzsas T.L., Kendall C.W., Sugano M., Iwamoto Y. and Rao A.V.-The influence of high and low molecular weight chitosan on colonic cell proliferation and abberant crypt foci development in CF1 mice.- Food Chem. Toxicol., 34, 73-77, 1996.
  • Miura T., Usami M., Tsuura Y., Ishida H. and Seino Y.- Hypoglicemic and hypolipidemic effect of chitosan in normal and neonatal streptozotocin-induced diabetic mice.-Biol. Pharm. Bull., 18, 1623-1625,1995.
  • Meler J, Pluta J and Krotkiewski M. The influence of various kinds of chitosan on fat binding ability. 4th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology. Florence, pp. 617-618, 2002.
  • Miyazaki S., Yamaguchi H., Tamada M., Hou W.M., Takeichi Y. and Yasubuchi H.- Pharmaceutical applications of biomedical polymers. XXIX. Preliminary study of film dosage form prepared from chitosan for oral drug delivery.- Acta. Pharm. Nord., 2, 401-406, 1990.
  • Meler J., Pluta J., Ulanski P. and Krotkiewski M. Fat- the binding capacity of ninths - the modified and modified chitosans. In: Progress The Chemistry and Application of Chitin and its Derivatives. Vol. IX (ed.: H. Struszczyk), Polish Chitin Society, Lodz, pp. 129-136, 2003.
Document Type
article
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YADDA identifier
bwmeta1.element.psjd-3e9f4704-2923-40b5-851a-10d9ca301ff1
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