Effects of fungus extract Pestalotiopsis microspora (Speg.) Bat. & Peres, 1966, on the antioxidant system of mice infected with Plasmodium berghei Vincke & Lips, 1948

• Authors: Kennedy Momoh Faysal , Olaitan Abdulkareem Adam , Olabisi Salaudeen Jibril , Oluwatosin Bamidele Esther , Ngutor Ayua Jerry , Adejoke Abdulrahim Latifah , Ngutor Simon Waya
• Languages of publication: EN

Abstracts

EN

The experiment is focused on evaluating the effect of Pestalotiopsis microspora on the antioxidant system of mice infected with Plasmodium berghei. Twenty-five male albino mice of average weight of 20kg were distributed randomly into 5 groups. Infected untreated (group 1), Infected untreated (group 2), Infected treated with chloroquine (group 3) Infected treated with 25 mg/kg fungus extract (group 4), Infected treated with 50 mg/kg fungus extract (group 5). All the groups were infected with Plasmodium berghei via the intra-peritoneal route. After seven days’ post infection, infected treated with chloroquine (group 3) Infected treated with 25 mg/kg fungus extract (group 4), Infected treated with 50 mg/kg fungus extract (group 5) were treated with chloroquine, 25 mg/kg and 50 mg/kg fungus extract respectively. The treatment lasted for 4 days. The results of this study revealed that, the effect of the fungus extract significantly increased the ALT, catalase, MDA, uric acid and XO in serum of infected treated group when compared with the decrease in the uninfected untreated group.

Keywords

EN

Pestalotiopsis microspora; Plasmodium berghei; Uric acid; blood glucose; chloroquine; male swiss albino mice; oxidative stress

Discipline

• MICROBIOLOGY: MICROBIOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2026
• Volume: 64
• Pages: 45-54

Contributors

author

Kennedy Momoh Faysal

• Department of Zoology, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

author

Olaitan Abdulkareem Adam

• Department of Zoology, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

author

Olabisi Salaudeen Jibril

• Department of Zoology, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

author

Oluwatosin Bamidele Esther

• Department of Zoology, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

author

Ngutor Ayua Jerry

• Department of Zoology, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

author

Adejoke Abdulrahim Latifah

• Department of Zoology, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

author

Ngutor Simon Waya

• Department of Biochemistry, Faculty of Life Sciences, University of Ilorin, Kwara State, Nigeria

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• Document Type: article