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2018 | 18 | 1 | 14–20
Article title

Depresja w chorobie Parkinsona. Rola farmakoterapii

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Title variants
EN
Depression in Parkinson’s disease. The role of pharmacotherapy
Languages of publication
PL
Abstracts
EN
Psychiatric symptoms seem to be an immanent part of Parkinson’s disease. Patients may present with psychotic symptoms, cognitive disorders, sleep disturbances (mainly associated with the REM sleep), dementia as well as depression and anxiety. Depression and anxiety are the most common psychiatric disorders, and are observed in nearly a half of patients with Parkinson’s disease. They are caused by both neurochemical and neuroanatomical abnormalities occurring in this disease. This decreases the quality of life and significantly affects patients’ functioning. Moreover, these disorders are frequently not diagnosed correctly. Numerous studies have shown that the most common drugs are those from the group of selective serotonin reuptake inhibitors. However, there is no strong evidence for their high efficacy. Due to the multifactorial mechanism of action, more effective, but also related with more adverse events, are selective norepinephrine reuptake inhibitors and tricyclic antidepressants. Daily practice and various publications reveal that non-ergoline dopamine agonists, such as ropinirole and pramipexole, may constitute an alternative to antidepressants.
PL
Objawy psychiatryczne wydają się immanentną częścią choroby Parkinsona. U pacjentów mogą wystąpić objawy psychotyczne, zaburzenia funkcji poznawczych, zaburzenia snu (związane przede wszystkim ze snem REM), zespół otępienny, objawy zespołu depresyjnego i zaburzenia lękowe. Depresja i lęk są najczęstszymi zaburzeniami psychiatrycznymi, obecnymi u prawie połowy osób z chorobą Parkinsona. U podstaw objawów depresyjnych i lękowych leżą zarówno zmiany neurochemiczne, jak i zmiany neuroanatomiczne występujące w tej chorobie. Obniżają one jakość życia, istotnie wpływają na funkcjonowanie pacjenta, a ich pojawienie się często nie jest właściwie rozpoznawane. Na podstawie licznych badań wiadomo, że najczęściej stosowane są leki z grupy selektywnych inhibitorów wychwytu zwrotnego serotoniny. Brakuje niestety mocnych dowodów na ich dużą skuteczność. Z uwagi na wielomediatorowy mechanizm działania dobrym wyborem – bardziej efektywnym, ale też związanym z większą liczbą działań niepożądanych – mogą być selektywne inhibitory wychwytu zwrotnego noradrenaliny i trójpierścieniowe leki przeciwdepresyjne. Jak wynika z codziennej praktyki i licznych publikacji, alternatywą dla leków przeciwdepresyjnych są nieergolinowi agoniści dopaminy, tacy jak ropinirol czy pramipeksol.
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Year
Volume
18
Issue
1
Pages
14–20
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Contributors
author
  • Zakład Psychologii Lekarskiej, Uniwersytet Medyczny w Łodzi, Łódź, Polska
References
  • Anisman H, Irwin J, Sklar LS: Deficits of escape performance following catecholamine depletion: implications for behavioral deficits induced by uncontrollable stress. Psychopharmacology (Berl) 1979; 64: 163–170.
  • Barone P, Scarzella L, Marconi R et al.; Depression/Parkinson Italian Study Group: Pramipexole versus sertraline in the treatment of depression in Parkinson’s disease: a national multicenter parallelgroup randomized study. J Neurol 2006; 253: 601–607.
  • Bostwick JM, Hecksel KA, Stevens SR et al.: Frequency of new-onset pathologic compulsive gambling or hypersexuality after drug treatment of idiopathic Parkinson disease. Mayo Clin Proc 2009; 84: 310–316.
  • Brown AS, Gershon S: Dopamine and depression. J Neural Transm Gen Sect 1993; 91: 75–109. Brust JC: Substance abuse and movement disorders. Mov Disord 2010; 25: 2010–2020.
  • Burn DJ: Beyond the iron mask: towards better recognition and treatment of depression associated with Parkinson’s disease. Mov Disord 2002; 17: 445–454.
  • Cannas A, Spissu A, Floris GL et al.: Bipolar affective disorder and Parkinson’s disease: a rare, insidious and often unrecognized association. Neurol Sci 2002; 23 Suppl 2: S67–S68.
  • Chondrogiorgi M, Tatsioni A, Reichmann H et al.: Dopamine agonist monotherapy in Parkinson’s disease and potential risk factors for dyskinesia: a meta-analysis of levodopa-controlled trials. Eur J Neurol 2014; 21: 433–440.
  • Clarke CE, Guttman M: Dopamine agonist monotherapy in Parkinson’s disease. Lancet 2002; 360: 1767–1769.
  • Cummings JL: Depression and Parkinson’s disease: a review. Am J Psychiatry 1992; 149: 443–454.
  • Cummings JL, Mega MS: Parkinson’s disease. In: Neuropsychiatry and Behavioral Neuroscience. Oxford University Press, New York 2003: 256–257.
  • de Lau LM, Breteler MM: Epidemiology of Parkinson’s disease. Lancet Neurol 2006; 5: 525–535.
  • Dunlop BW, Nemeroff CB: The role of dopamine in the pathophysiology of depression. Arch Gen Psychiatry 2007; 64: 327–337.
  • Elbaz A: Prodromal symptoms of Parkinson’s disease: implications for epidemiological studies of disease etiology. Rev Neurol (Paris) 2016; 172: 503–511.
  • Etminan M, Gill S, Samii A: Comparison of the risk of adverse events with pramipexole and ropinirole in patients with Parkinson’s disease: a meta-analysis. Drug Saf 2003; 26: 439–444.
  • Frisina PG, Borod JC, Foldi NS et al.: Depression in Parkinson’s disease: health risks, etiology, and treatment options. Neuropsychiatr Dis Treat 2008; 4: 81–91.
  • Frucht S, Rogers JD, Greene PE et al.: Falling asleep at the wheel: motor vehicle mishaps in persons taking pramipexole and ropinirole. Neurology 1999; 52: 1908–1910.
  • Galati S, Möller JC, Städler C: Ropinirole-induced Pisa syndrome in Parkinson disease. Clin Neuropharmacol 2014; 37: 58–59.
  • Garcia-Ruiz PJ, Martinez Castrillo JC, Alonso-Canovas A et al.: Impulse control disorder in patients with Parkinson’s disease under dopamine agonist therapy: a multicentre study. J Neurol Neurosurg Psychiatry 2014; 85: 840–844.
  • Global Parkinson’s Disease Survey (GPDS) Steering Committee: Factors impacting on quality of life in Parkinson’s disease: results from an international survey. Mov Disord 2002; 17: 60–67.
  • Hauser RA, Gauger L, Anderson WM et al.: Pramipexole-induced somnolence and episodes of daytime sleep. Mov Disord 2000; 15: 658–663.
  • Isais-Millán S, Piña-Fuentes D, Guzmán-Astorga C et al.: [Prevalence of neuropsychiatric disorders in drug-naïve subjects with Parkinson’s disease (PD)]. Gac Med Mex 2016; 152: 357–363.
  • Ishihara L, Brayne C: A systematic review of depression and mental illness preceding Parkinson’s disease. Acta Neurol Scand 2006; 113: 211–220.
  • Kleiner-Fisman G, Fisman DN: Risk factors for the development of pedal edema in patients using pramipexole. Arch Neurol 2007; 64: 820–824.
  • Kulisevsky J, Pagonabarraga J: Tolerability and safety of ropinirole versus other dopamine agonists and levodopa in the treatment of Parkinson’s disease: meta-analysis of randomized controlled trials. Drug Saf 2010; 33: 147–161.
  • Kuzis G, Sabe L, Tiberti C et al.: Cognitive functions in major depression and Parkinson disease. Arch Neurol 1997; 54: 982–986.
  • Lammers CH, Diaz J, Schwartz JC et al.: Selective increase of dopamine D3 receptor gene expression as a common effect of chronic antidepressant treatments. Mol Psychiatry 2000; 5: 378–388.
  • Leentjens AFG, Van den Akker M, Metsemakers JFM et al.: Higher incidence of depression preceding the onset of Parkinson’s disease: a register study. Mov Disord 2003; 18: 414–418.
  • Lisanby SH, McDonald WM, Massey EW et al.: Diminished subcortical nuclei volumes in Parkinson’s disease by MR imaging. J Neural Transm Suppl 1993; 40: 13–21.
  • Liu J, Dong J, Wang L et al.: Comparative efficacy and acceptability of antidepressants in Parkinson’s disease: a network meta-analysis. PLoS One 2013; 8: e76651.
  • Maillet A, Krack P, Lhommée E et al.: The prominent role of serotonergic degeneration in apathy, anxiety and depression in de novo Parkinson’s disease. Brain 2016; 139: 2486–2502.
  • Mayberg HS, Brannan SK, Mahurin RK et al.: Cingulate function in depression: a potential predictor of treatment response. Neuroreport 1997; 8: 1057–1061.
  • Mayberg HS, Starkstein SE, Sadzot B et al.: Selective hypometabolism in the inferior frontal lobe in depressed patients with Parkinson’s disease. Ann Neurol 1990; 28: 57–64.
  • McDonald WM, Krishnan KR: Magnetic resonance in patients with affective illness. Eur Arch Psychiatry Clin Neurosci 1992; 241: 283–290.
  • McDonald WM, Richard IH, DeLong MR: Prevalence, etiology, and treatment of depression in Parkinson’s disease. Biol Psychiatry 2003; 54: 363–375.
  • Nashatizadeh MM, Lyons KE, Pahwa R: A review of ropinirole prolonged release in Parkinson’s disease. Clin Interv Aging 2009; 4: 179–186.
  • National Collaborating Centre for Chronic Conditions (UK); National Institute for Health and Clinical Excellence: Guidance: Parkinson’s Disease: National Clinical Guideline for Diagnosis and Management in Primary and Secondary Care. Royal College of Physicians (UK), London 2006: 242.
  • Nègre-Pagès L, Grandjean H, Lapeyre-Mestre M et al.: Anxious and depressive symptoms in Parkinson’s disease: the French cross-sectional DoPAMiP study. Mov Disord 2010; 25: 157–166.
  • Nilsson FM, Kessing LV, Bolwig TG: Increased risk of developing Parkinson’s disease for patients with major affective disorder: a register study. Acta Psychiatr Scand 2001; 104: 380–386.
  • Nirenberg MJ, Waters C: Compulsive eating and weight gain related to dopamine agonist use. Mov Disord 2006; 21: 524–529.
  • Norman S, Tröster AI, Fields JA et al.: Effects of depression and Parkinson’s disease on cognitive functioning. J Neuropsychiatry Clin Neurosci 2002; 14: 31–36.
  • Pahwa R, Stacy MA, Factor SA et al.; EASE-PD Adjunct Study Investigators: Ropinirole 24-hour prolonged release: randomized, controlled study in advanced Parkinson disease. Neurology 2007; 68: 1108–1115.
  • Rektorova I, Balaz M, Svatova J et al.: Effects of ropinirole on nonmotor symptoms of Parkinson disease: a prospective multicenter study. Clin Neuropharmacol 2008; 31: 261–266.
  • Ring HA, Bench CJ, Trimble MR et al.: Depression in Parkinson’s disease. A positron emission study. Br J Psychiatry 1994; 165: 333–339.
  • Santangelo G, Falco F, D’Iorio A et al.: Anxiety in early Parkinson’s disease: validation of the Italian observer-rated version of the Parkinson Anxiety Scale (OR-PAS). J Neurol Sci 2016; 367: 158–161.
  • Schapira AH, McDermott MP, Barone P et al.: Pramipexole in patients with early Parkinson’s disease (PROUD): a randomised delayedstart trial. Lancet Neurol 2013; 12: 747–755.
  • Schrag A, Jahanshahi M, Quinn N: What contributes to quality of life in patients with Parkinson’s disease? J Neurol Neurosurg Psychiatry 2000; 69: 308–312.
  • Schuurman AG, van den Akker M, Ensinck KT et al.: Increased risk of Parkinson’s disease after depression: a retrospective cohort study. Neurology 2002; 58: 1501–1504.
  • Shabnam GN, Th C, Kho D et al.: Therapies for depression in Parkinson’s disease. Cochrane Database Syst Rev 2003; (3): CD003465.
  • Shannon KM, Bennett JP Jr, Friedman JH: Efficacy of pramipexole, a novel dopamine agonist, as monotherapy in mild to moderate Parkinson’s disease. The Pramipexole Study Group. Neurology 1997; 49: 724–728.
  • Skapinakis P, Bakola E, Salanti G et al.: Efficacy and acceptability of selective serotonin reuptake inhibitors for the treatment of depression in Parkinson’s disease: a systematic review and meta-analysis of randomized controlled trials. BMC Neurol 2010; 10: 49.
  • Sławek J, Derejko M, Lass P: Factors affecting the quality of life of patients with idiopathic Parkinson’s disease – a cross-sectional study in an outpatient clinic attendees. Parkinsonism Relat Disord 2005; 11: 465–468.
  • Srivastava A, Tang MX, Mejia-Santana H et al.: The relation between depression and parkin genotype: the CORE-PD study. Parkinsonism Relat Disord 2011; 17: 740–744.
  • Stahl SM: Podstawy psychofarmakologii. Teoria i praktyka. Via Medica, Gdańsk 2010.
  • Starkstein SE, Bolduc PL, Mayberg HS et al.: Cognitive impairments and depression in Parkinson’s disease: a follow up study. J Neurol Neurosurg Psychiatry 1990; 53: 597–602.
  • Starkstein SE, Bolduc PL, Preziosi TJ et al.: Cognitive impairments in different stages of Parkinson’s disease. J Neuropsychiatry Clin Neurosci 1989; 1: 243–248.
  • Stowe RL, Ives NJ, Clarke C et al.: Dopamine agonist therapy in early Parkinson’s disease. Cochrane Database Syst Rev 2008; (2): CD006564.
  • Tandberg E, Larsen JP, Aarsland D et al.: Risk factors for depression in Parkinson disease. Arch Neurol 1997; 54: 625–630.
  • Troeung L, Egan SJ, Gasson N: A meta-analysis of randomised placebo-controlled treatment trials for depression and anxiety in Parkinson’s disease. PLoS One 2013; 8: e79510.
  • Vela L, Martínez Castrillo JC, García Ruiz P et al.: The high prevalence of impulse control behaviors in patients with early-onset Parkinson’s disease: a cross-sectional multicenter study. J Neurol Sci 2016; 368: 150–154.
  • Wehling M (ed.): Drug Therapy for the Elderly. Springer, Wien 2012. Weintraub D, Morales KH, Moberg PJ et al.: Antidepressant studies in Parkinson’s disease: a review and meta-analysis. Mov Disord 2005; 20: 1161–1169.
  • Zięba A, Dudek D: Depresja: patofizjologia, terapia, depresje lekooporne. In: Nowak G (ed.): Cynk w fizjologii, patofizjologii i terapii depresji. Instytut Farmakologii PAN, Kraków 2001: 57–64.
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article
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bwmeta1.element.psjd-3b77e3d0-edcf-413d-89bb-461b745496ab
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