PL EN


Preferences help
enabled [disable] Abstract
Number of results
2016 | 35 | 62-72
Article title

Autosomal DNA Polymorphisms of Four South India Tribal Populations

Content
Title variants
Languages of publication
EN
Abstracts
EN
Background: The entry and dispersal of modern humans is India of remains unclear and extending with many interesting evidences South India, assumed to be a major corridor for their with many ancient genetic deposits such as Dravidian tribal with Negrito features. As the relationships between the genetic polymorphs and diseases in human being revealed globally, it is worthy to investigate the genomic architecture of population in south India. Objective: To examine what evolutionary forces have most significantly impacted south Indian tribal genetic variation, and to test whether the phenotypic similarities of some south Indian tribal groups to Africans represent a signature of close relationship to Africans or are due to convergence. Methods: Blood samples from 193 unrelated individuals of both sexes are drawn from the Dravidian tribal settlements of Tamil Nadu and Kerala. South India are genotyped for four Aluindel (Alu FXIIIB, Alu ACE, AluTA25 and Alu PLAT) allele profile by PCR genotyping method. Results: All loci are highly polymorphic and average heterozygositiesare substantial (range: 0.37-0.44). Genetic differentiation is high (Gst = 3.7%) in all the study populations.
Discipline
Publisher

Year
Volume
35
Pages
62-72
Physical description
Contributors
author
  • PG and Research Department of Zoology, Periyar E.V.R. College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India
author
  • PG and Research Department of Zoology, Periyar E.V.R. College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India, drnkzoo@gmail.com
author
  • PG and Research Department of Zoology, Periyar E.V.R. College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India
  • PG and Research Department of Zoology, Periyar E.V.R. College (Autonomous), (Affiliated to Bharathidasan University), Tiruchirappalli, Tamil Nadu, India
References
  • [1] Cavalli-Sforza LL, Menozzi P, Piazza A. The History and Geography of Human Genes Princeton: Princeton University Press; 1994.
  • [2] Sanghvi LD, Balakrishnan V, Karve I. Biology of the People of Tamil Nadu. Indian Society of Human Genetics, Pune, and The Indian Anthropological Society, Kolkata. 1981.
  • [3] Harris H, Hopkinson DA. Hand book of Enzyme Electrophoresis in Human Genetics. Amsterdam: North Holland. 1976
  • [4] Festenstein H, Adams E, Burke JM, Oliver RT, Sachs JA, Wolf E. Histocompatibility Testing. Copenhagen: Munksgaard. 1972.
  • [5] Dobazhansky T. Genetic Diversity and Human Equality. New York: Basic Books 1973
  • [6] Bhasin MK, Walter H, Danker-Hopfe H. People of India. An Investigation of Biological Variability in Ecological, Ethno-Economic and Linguistic Groups. Delhi: Kamla-Raj Enterprises. 1994.
  • [7] Pitchappan RM, Balakrishnan K, Sundarsen V et al.. Sociobiology and HLA genetic polymorphism in hill tribes, Irulas of Nilgiris and Malayalis of Shevroy, South India. Human Biology, 1997; 69: 59-74.
  • [8] Pitchappan RM. Castes, migration, immunogenetics, infectious diseases and South India. Community Genet, 2002; 5: 157-161.
  • [9] Basu A, Mukherjee N, Roy S et al. Ethnic India: A genomic view, with special reference to peopling and structure. Genome Res, 2003; 13(10): 2277-2290.
  • [10] Singh PK, Bourque G, Craig NL, Dubnau J T, Feschotte C et al.. Mobile genetic elements and genome evolution. Mobile DNA, 2014; 5: 26.
  • [11] Krishnaveni. A and Prabhakaran. K. Alu Insertion/Deletion Polymorphism in Four Tribes of South India. Int J Hum Genet, 2015; 15(2): 81-87.
  • [12] Inanir A, Ceniklib A, Turalc E, Tekcanc A, Turalc S et al. Molecular analysis of genetic variation in angiotensin I-converting enzyme gene in Turkish athletes. Int J Hum Genet, 2014; 14(2): 101-105.
  • [13] Stoneking M, Fontius JJ, Clifford SL, Soodyall H, Arcot S et al. Alu insertion/ deletion polymorphism and human evolution: Evidence for a larger population size in Africa. Genome Res, 1997; 7: 1061- 1071.
  • [14] Majumder PP, Roy B, Banerjee S, Chakraborty M, Dey B et al. Human - specific insertion /deletion polymorphisms in Indian populations and their possible evolutionary implications. Eur J Hum Genet, 1999; 7: 435-446.
  • [15] Yeh FC, Yang RC. A Joint Project Development: POPGENE 1.32. Centre for International Forestry Research. Canada: University of Alberta and TimBoyle. 1999.
  • [16] Tamura K ,Glen Stecher G, Peterson D, Filipski A, and Kumar S. MEGA6: Molecular Evolutionary Genetics Analysis Version 6.0. Mol. Biol. Evol. 2013; 30(12): 2725-2729.
  • [17] Vishwanathan H, Deepa E, Usha Rani MV, Majumder PP. Insertion/deletion polymorphisms in tribal populations of southern India and their possible evolutionary implications. Human Biology, 2003; 75(6): 873-887.
  • [18] Veerraju P, Demarche DA, Lakshmi N, Venkateswarirao T. Insertion/deletion polymorphisms in Indian tribal populations. Int J Hum Genet, 2008; 8(1-2): 75-83.
  • [19] Watkins WS, Ricker CE, Bamshad MJ, Carroll ML, Nguyen SV, et al. Patterns of ancestral human diversity: An analysis of Alu insertion and restrict polymorphisms. Am J Hum Genet, 2001; 68: 738-752.
  • [20] Kanthimathi A, Vijaya M, Ramesh A. Genetic study of Dravidian caste of Tamil Nadu. J Genet, 2008; 87(2): 175-179.
  • [21] Yadav AB, Arora P. Genomic diversity and affinities among eight endogamous groups of Haryana (India): A study on insertion/deletion polymorphisms. Ann Hum Bio, 2011; 38(1): 114-118.
  • [22] Dada R, Saraswathy KN, Mettei KS, Mondal PR, Kaur H et al. Genetic sketch of the six population groups of Rajasthan: A study based on 12 autosomal loci. Anthrop Science, 2011; 119: 259 264.
  • [23] Kshatriya GK, Aggarwal A, Khurana P, Italia YM. Genomic congruence of Indo-European speaking tribes of western India with Dravidian-speaking populations of Southern India: A study of 20 autosomal DNA markers. Ann Hum Biol, 2011; 38(5): 583-591.
  • [24] Panjaliya RK, Dogra V, Kumar P, Gupta S. Human specific Alu insertion/deletion polymorphisms in various population groups of Jammu region. Int J Hum Genet, 2012; 12(4): 311-317.
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-37ad5ca3-751f-413a-ac39-71d76e4e8dda
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.