Zwyrodnienie plamki związane z wiekiem. Część II: metody leczenia – chirurgiczne, monoterapia i terapie złożone

• Authors: Adam Jarmak

Title variants

EN

Age related macular degeneration. Part II: therapeutic options – surgical, pharmacological and composite therapies

• Languages of publication: PL

Abstracts

PL

Zwyrodnienie plamki związane z wiekiem jest najczęstszą przyczyną utraty widzenia centralnego. Proces chorobowy obejmuje region plamkowy siatkówki i prowadzi do znacznego pogorszenia ostrości wzroku, a co za tym idzie – jakości życia. Chory traci możliwość uprawiania dotychczas wykonywanego zawodu, czytania, oglądania telewizji czy prowadzenia samochodu. Schorzenie to jest wyraźnie związane z procesami starzenia się i degeneracji tkanek i zazwyczaj pojawia się po 50. r.ż. Dopiero kilka lat temu wprowadzono środki farmakologiczne i inne metody terapeutyczne, które zdecydowanie poprawiły szanse na zachowanie użytecznej ostrości wzroku. Przełomowym odkryciem było klinicznie potwierdzone zahamowanie endotelialnego czynnika wzrostu, powodującego neowaskularyzację, co skutkowało brakiem wzrostu nieprawidłowych naczyń i w efekcie chroniło nie tylko przed spadkiem ostrości wzroku, ale nawet tę funkcję poprawiało. To była prawdziwa rewolucja w okulistyce, która dała pacjentom nadzieję na całkowite wyleczenie. Jednak czy jest ono możliwe? Jak wskazują doświadczenia kliniczne i doniesienia badaczy, walka o zahamowanie rozwoju choroby trwa. Leczenie chirurgiczne, leki podawane miejscowo i ogólnie, plazmafereza, wirusy wektorowe, radioterapia to tylko niektóre sposoby w walce o zachowanie widzenia centralnego. Arsenał terapeutyczny stale i intensywnie się poszerza i daje nadzieję na powstrzymanie rozwoju schorzenia.

EN

Macular degeneration associated with age is a leading cause of central vision loss. The disease process involves macular area of the retina and leads to a significant deterioration of visual acuity and, thus, a quality of life. A patient loses the opportunity to practice their profession, read, watch TV or drive. This condition is significantly associated with aging and degeneration of tissues and usually occurs after age of 50. Pharmaceuticals and other therapeutic approaches were introduced a few years ago and they substantially improved the prognosis for keeping the useful field of vision. The breakthrough discovery was clinically confirmed inhibition endothelial growth factor, causing neovascularization, which resulted in the lack of growth of abnormal vessels and as a result protected not only against the decrease in visual acuity, but even improved this function. It was a real revolution in ophthalmology, which gave patients hope for a full recovery. But is it possible? As practice and researchers’ reports show, struggle to inhibit the progress of the disease continues. Surgical treatment, topical drugs administered systemically, plasmapheresis, virus vector and radiotherapy are examples of the ways to fight to preserve central vision. The therapeutic arsenal is expanding rapidly and gives hope to inhibit the development of the disease.

Keywords

EN

glikokortykosteroidy; leczenie chirurgiczne; lentiwirusy; nowe terapie AMD; plazmafereza; radioterapia; terapie złożone w AMD

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OphthaTherapy
• Year: 2015
• Volume: 2
• Issue: 1
• Pages: 31-45

Contributors

author

Adam Jarmak

• Wojewódzki Szpital Specjalistyczny im. Marii Skłodowskiej-Curie w Zgierzu

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