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2017 | 76 | 66-84
Article title

Bordetella pertussis – the returning pathogen

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Abstracts
EN
Bordetella pertussis is a non-motile, Gram-negative coccobacillus belonging to the genus Bordetella. It is the causative agent of pertussis – a respiratory tract infection also known as whooping cough or 100-days’ cough. A similar bacterium, Bordetella parapertussis, is responsible for a proportion of pertussis cases, which are distinguished by milder symptoms. Two major virulence factors of Bordetella pertussis are adhesins (filamentous hemagglutinin and fimbriae) which facilitate tracheal colonization – the first step leading to infection. In pediatric population B. pertussis infection tends to take a highly unpredictable and sometimes fatal course. Antimicrobial drugs of macrolide class are the mainstay of therapy mainly due to their superb activity against Bordetella pertussis. However, antibiotic administration is ineffective in alleviating symptoms of whooping cough. Therefore, in the first half of the 20th century there was a collective effort of scientific community to create an efficient vaccine against B. pertussis. These endeavors proved fruitful and culminated in the implementation of vaccination programs since 1940s. Despite the widespread availability of vaccines, pertussis remains a significant cause of children morbidity to this day. Epidemiological data gathered in Poland during the last 10 years clearly imply that the disease incidence is steadily increasing. Furthermore, pertussis outbreaks, which happened every few years in the past, nowadays occur almost every other year. The reasons behind the alarming resurgence of pertussis are multifold, but two elements are presumed to play a key role: the waning immunity of adolescents who were vaccinated many years ago; and the parents’ reluctance to vaccinate their offspring. On account of the steady growing number of pertussis cases, the definite causes of the current epidemiological state ought to be determined and an adequate approach to combat theses reasons must be undertaken.
Year
Volume
76
Pages
66-84
Physical description
Contributors
  • Department of Medical Microbiology, Medical University of Lublin, 1 W. Chodźki Str., 20-093 Lublin, Poland
  • Department of Medical Microbiology, Medical University of Lublin, 1 W. Chodźki Str., 20-093 Lublin, Poland
  • Department of Medical Microbiology, Medical University of Lublin, 1 W. Chodźki Str., 20-093 Lublin, Poland
author
  • Department of Medical Microbiology, Medical University of Lublin, 1 W. Chodźki Str., 20-093 Lublin, Poland
References
  • [1] J. Bordet, O. Gengou, Ann Inst Pasteur 20 (1906) 731-741
  • [2] J. H. Lapin, Whooping Cough, Springfield, IL, 1943.
  • [3] J. D. Cherry, N Engl J Med 367 (2012) 785-787
  • [4] J. A. Melvin, E. V. Scheller, J. F. Miller et al., Nat Rev Microbiol 12 (2014) 274-288.
  • [5] Paccani S. R., Dal Molin F. D., Benagiano M. et al., Infect Immun 76 (2008) 2822-2832
  • [6] M. Pittman, Pediatr Infect Dis 3 (1984) 467-486
  • [7] N. H. Carbonetti, G.V. Artamonova, N. Van Rooijen et al., Infect Immun 75 (2007) 1713-1720
  • [8] K. E. Luker, A. N. Tyler, G. R. Marshall et al., Mol Microbiol 16 (1995) 733-743
  • [9] K. E. Walker and A.A. Weiss, Infect Immun 62 (1994) 3817-3828
  • [10] R. E. Black, H. L. Johnson, S. Cousens et al., The Lancet 375 (2010) 1969-1987
  • [11] S. Mattoo, J. D. Cherry, Clin Microbiol Rev 18 (2005) 326-382
  • [12] S. A. Halperin, N Engl J Med 356 (2007) 110-113
  • [13] Centers for Disease Control and Prevention (CDC), MMWR Morb Mortal Wkly Rep 61 (2012) 517-522.
  • [14] J. D. Cherry, Curr Probl Pediatr 14 (1984) 1-78
  • [15] S. A. Halperin, E. E. Wang, B. Law et al., Clin Infect Dis 28 (1999) 1238-1243
  • [16] J. D. Cherry, Pediatrics 129 (2012) 968-970
  • [17] K. Winter, K. Harriman, J. Zipprich et al., Pediatrics 161 (2012) 1091-1096
  • [18] M. Kulenkamp, J. S. Schwartzman and J. Wilson, Arch Dis Child 49 (1974) 46-49
  • [19] A. J. Wakefield, S. H. Murch, A. Antohny et al., The Lancet 351 (1998) 637-641
  • [20] V. Waters, F. Jamieson, S. E. Richardson et al., Pediatr Infect Dis J 126 (2009) 582-587
  • [21] J. D. Cherry, E. Grimprel, N. Guiso et al., Pediatr Infect Dis J 24 (2005) S25-S34
  • [22] M. M. Cortese, A.L. Baughman, R. Zhang et al., Pediatrics 121 (2008) 484-492
  • [23] N. S. Crowcroft, R. Booy, T. Harrison et al., Arch Dis Child 88 (2003) 802-806
  • [24] C.C. Grant, E. J. McKay, A. Simpson et al., Pediatrics 102 (1998) 986-990
  • [25] N. Guiso, G. Berbers, N. K. Fry et al., Eur J Clin Microbiol 30(3) (2011) 307-312
  • [26] J. R. Lingappa, W. Lawrence, S. West-Keefe et al., J Clin Microbiol 40 (2002) 2908-2912
  • [27] D.M. Dragsted, B. Dohn, J. Madsen et al., J Med Microbiol 53 (2004) 749-754
  • [28] P. Bidet, S. Liguori, A. De Lauzanne et al., J Clin Microbiol 46 (2008) 3636-3638
  • [29] H. Salimnia, P.R. Lephart, B.I. Asmar et al., J Clin Microbiol 50 (2012) 472-474
  • [30] S. Altunaiji, R. Kukuruzovic, N. Curtis et al., Cochrane Database Syst Rev 3 (2007) CD004404
  • [31] S. O. Bergquist, S. Bernander, H. Dahnsjo et al., Pediatr Infect Dis J, 6 (1987) 458-461.
  • [32] N. Maheshwai, Arch Dis Child 92 (2007) 271-273
  • [33] S. Bettiol, K. Wang, M. J. Tompson et al., Cochrane Database Syst Rev 5 (2012) CD003257
  • [34] P. L. Kendrick, G. Eldering, M. K. Dixon et al., Am J Publ Health Nations Health 37 (1947) 803-810
  • [35] N. LeSaux, N.J. Barrowman, D.L. Moore et al., Pediatrics 112 (2003) e348
  • [36] Y. Sato, M. Kimura, H. Fukumi, The Lancet 1 (1984) 122-126
  • [37] Centers for Disease Control and Prevention (CDC) - Advisory Committee on Immunization Practices (ACIP), MMWR Recomm Rep 60 (RR02) (2011) 1-60
  • [38] G. Amirthalingam, N. Andrews, H. Cambell et al., The Lancet 384 (2014) 1521-1528
  • [39] S. A. Halperin, R. Bortolussi, J. M. Langley et al., Pediatrics 104 (1999) e42
Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-2fefb066-7603-484f-aa08-d827a32af17d
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