Synthesis, Characterization, Mesomorphic Study of Some Novel Sulphonamide Schiff Base Derivatives and their Antimicrobial Evaluation

• Authors: Jatin R. Rana , Vinay S. Sharma , Nikhil K. Agarwal , Jaimin Panchal , Rakesh Gothwal
• Languages of publication: EN

Abstracts

EN

The new series of sulphonamide schiff base compounds obtained from sulfa drugs has been synthesized by the reaction of 4,4'-Diaminodiphenyl sulfone with aldehydes. The synthesized compounds were characterized by using FT-IR, Mass spectroscopy to confirm the chemical structures of synthesized compounds. The sulfonamide Schiff base compounds were tested for anti-bacterial, anti-fungal and anti-malarial. The biological activity of synthesized compounds was evaluated by assessing the inhibitory concentration by measuring their inhibition zone versus certain kinds of standard antibiotics. Noticeably, compound 4a, 5b, 5c was the most potent compound in vitro anti-microbial with compare to reference drug. In addition, two compounds exhibited liquid crystalline property.

Keywords

EN

Diaminodiphenyl sulfone; Liquid crystals; anti-bacterial; anti-fungal; schiff base

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World Scientific News
• Year: 2022
• Volume: 168
• Pages: 69-80

Contributors

author

Jatin R. Rana

• Department of Chemistry, Faculty of Basic and Applied Science, Madhav University, Rajasthan, India

author

Vinay S. Sharma

• Department of Chemistry, School of Science, Gujarat University, Gujarat, India

author

Nikhil K. Agarwal

• Department of Chemistry, Faculty of Basic and Applied Science, Madhav University, Rajasthan, India

author

Jaimin Panchal

• Department of Chemistry, School of Science, Gujarat University, Gujarat, India

author

Rakesh Gothwal

• Department of Life Science, Faculty of Basic and Applied Science, Madhav University, Rajasthan, India

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• Document Type: article