Zaburzenia funkcji układu oddechowego i układu krążenia u chorych na mastocytozę

• Authors: Marlena Sztormowska , Marek Niedoszytko

Title variants

EN

Pulmonary and cardiovascular symptoms in patients with mastocytosis

• Languages of publication: PL EN

Abstracts

PL

Mastocytoza jest rzadką chorobą mieloproliferacyjną związaną z roz-rostem mastocytów oraz ich gromadzeniem w narządach takich jak skóra, błony śluzowe, szpik, wątroba, śledziona, węzły chłonne i inne. Mnogość objawów związana jest z naciekaniem przez mastocyty różnych narządów, także z uwalnianiem przez nie mediatorów takich jak histamina i prostaglandyny.Artykuł jest przeglądem piśmiennictwa dotyczącego rzadkich manifestacji chorób komórek tucznych. Płucna i sercowo-naczyniowa lokalizacja mastocytozy jest bardzo rzadka. Wiele przypadków nie ma potwierdzenia histopatologicznego. Zespół Kounisa jest współwystępowaniem ostrych zespołów wieńcowych obejmujących skurcz naczyń wieńcowych, ostry zawał mięśnia sercowego i zakrzepicę w stencie w przebiegu reakcji alergicznej, nadwrażliwości lub reakcji anafilaktoidalnej. Kardiomiopatia Takotsubo jest przejściową lokalną dysfunkcją skurczową i rozkurczową lewej komory. Zajęcie płuc w przebiegu mastocytozy objawia się najczęściej nadwrażliwością oskrzeli podobnie jak w przebiegu astmy i obecnością drobnych guzków w tkance płucnej.

EN

Mastocytosis is a group of rare diseases characterized by excessive growth of mast cells in skin, mucous membranes, bone marrow, liver, spleen, lymph nodes. Signs and symptoms result mostly from mast cells mediators, like histamine and prostaglandins, and mast cells or-gan infiltration.In this article we describe based on the available literature uncommon manifestations of mast cell disorder. Pulmonary and cardiovascular localization of mastocytosis is extremely rare and in most instances have not been substantiated with pathologic confirmation. Kounis syndrome is a coronary hypersensitivity disorder known also as syndro-me of allergic angina or allergic myocardial infarction in the course of an allergic, hypersensitivity, anaphylactic, and anaphylactoid reaction. Takotsubo cardiomyopathy is a syndrome characterized by transient regional systolic and diastolic dysfunction of the left ventricle leading to a variety of wall motion abnormalities. The pulmonary involment in mastocytosis is demonstrated by asthma-like bronchial hyperreactivity or intrapulmonary nodules

Keywords

EN

astma; histamina; kardiomiopatia; komórka tuczna; mastocytoza

Discipline

• MEDICINE: MEDICINE

• Publisher: Oficyna Wydawnicza Mediton
• Journal: Alergia Astma Immunologia - przegląd kliniczny
• Year: 2019
• Volume: 24
• Issue: 1
• Pages: 12-17

Contributors

author

Marlena Sztormowska

• Klinika Alergologii Katedry Pneumonologii i Alergologii Gdańskiego Uniwersytetu Medycznego, Gdańsk

author

Marek Niedoszytko

• Klinika Alergologii Katedry Pneumonologii i Alergologii Gdańskiego Uniwersytetu Medycznego, Gdańsk

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• Document Type: article