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2018 | 102 | 30-46
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Current clinical management of malignant melanoma – diagnosis process and innovative therapies

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Malignant melanoma is a highly invasive cancer which derives from neuroectodermic melanocytic cells. It is characterized by the highest frequency of cases in both sexes and all age groups. High metastatic potential of melanoma and its multidrug resistance might be a significant problem in the treatment. Permanent and complete remissions are rare, while the 5-year survival rate remains relatively low. In the last years there has been a breakthrough in the systemic therapy of malignant melanoma. Modern drugs have revolutionized previous therapeutic management of melanoma. As part of therapeutic programs, new medicines are available: dabrafenib, ipilimumab, pembrolizumab, trametinib and vemurafenib. The following paper presents current clinical management standards for melanoma diagnoses, based on the widely accepted scientific data and expert experience - with emphasis on modern methods of treatment of this cancer.
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