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Article title

Stężenie oreksyn A i B (OXA i OXB) oraz greliny (GRE) w osoczu chorych z jadłowstrętem psychicznym – doniesienie wstępne

Title variants
Concentrations of orexins A and B (OXA and OXB) and ghrelin (GRE) in anorexia nervosa patients’ plasma – introductory report
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Introduction: Analysis of the occurrence of anorexia nervosa involves the possible contribution of orexigenic peptides, including orexins A and B, ghrelin, galanin, neuropeptide Y and anorexigenic peptides which are represented by leptin, proopiomelanocortin (POMC), or transcript regulated by cocaine and amphetamine (CART). Aim: The study was aimed at examining the correlation between the concentrations of orexigenic peptides: orexins A and B (OXA and OXB) and ghrelin (GRE) in plasma and the body mass index (BMI) in AN patients. Material and method: The study involved 25 girls with anorexia nervosa. The reference group consisted of 20 healthy girls. In all of them the plasma concentration of OXA, OXB, GRE and glucose was determined once. The blood was drawn on empty stomach, in the morning after 8-hours fasting. The concentration of OXA and OXB was measured using commercial radioimmunological sets made by Phoenix Pharmaceuticals, Mountain View, California. The concentration of total GRE was determined using commercial radioimmunological sets made by Linci Research, INC. The procedure was applied pursuant to the procedure recommended by Phoenix. Results: In AN patients, of three analysed orexigenic peptides OXA, OXB and GRE only two – OXA and GRE significantly changed their plasma concentration in acute phase of the disease. OXA concentration in AN patients’ plasma was statistically significantly lower, whereas GRE concentration – statistically significantly higher, as compared to the reference group. At the same time a statistically significantly positive correlation was found between OXA concentration and BMI value and statistically significantly negative correlation between the concentration of GRE and BMI. Conclusions: In patients with anorexia nervosa (mainly its restrictive form) OXA and GRE significantly change their plasma concentration in acute phase of the disease.
W powstawaniu jadłowstrętu psychicznego (anorexia nervosa, AN) rozpatruje się udział peptydów oreksygenicznych i anoreksygenicznych. Celem pracy było zbadanie zależności pomiędzy stężeniami: oreksyn A i B (OXA i OXB) oraz greliny (GRE) w osoczu a wskaźnikiem masy ciała (BMI) u chorych z AN. Badaniem objęto 25 dziewcząt z jadłowstrętem psychicznym. Grupę odniesienia stanowiło 20 zdrowych dziewcząt. U wszystkich oznaczano jednorazowo w osoczu stężenie OXA, OXB, GRE i glukozy. U chorych z AN, spośród trzech analizowanych peptydów oreksygenicznych: OXA, OXB i GRE jedynie dwa z nich – OXA i GRE zmieniły istotnie swoje stężenie w osoczu w ostrej fazie choroby. Stężenie OXA w osoczu chorych z AN było statystycznie istotnie niższe, a stężenie GRE – statystycznie istotnie wyższe niż w grupie odniesienia. Jednocześnie wykazano statystycznie istotną dodatnią korelację pomiędzy stężeniem OXA a wartością BMI i statystycznie istotną ujemną korelację pomiędzy stężeniem GRE a BMI.
Physical description
  • Katedra i Klinika Psychiatrii i Psychoterapii SAM w Katowicach Oddział Psychiatrii Wieku Rozwojowego - Centrum Pediatrii w Sosnowcu
  • 1. Beuckmann-Carsten T., Yanagisawa M.: Orexins: from neuropeptides to energy homeostasis and sleep/wake regulation. J. Mol. Med. 2002; 80: 329-342.
  • 2. Cai X.J., Liu X.H., Evans M. i wsp.: Orexins and feeding: special occasions or everyday occurrence? Regul. Pept. 2002; 104: 1-9.
  • 3. Jones D.N., Gartlon J., Parker F. i wsp.: Effects of centrally administered orexin-B and orexin-A: a role for orexin-1 receptors in orexin-B-induced hyperactivity. Psychopharmacology 2001; 153: 210-218.
  • 4. Kurose T., Ueta Y., Yamamoto Y. iwsp.: Effects of restricted feeding on the activity of hypothalamic orexin (OX)-A containing neurons an OX2 receptor mRNA level in the paraventricular nucleus of rats. Regul. Pept. 2002; 104: 145-151.
  • 5. Lee H.M., Wang G., Englander E.W i wsp.: Ghrelin, a new gastrointestinal endocrine peptide that stimulates insulin secretion: enteric distribution, ontogeny, influence of endocrine and dietary manipulations. Endocrinology 2002; 143: 185-190.
  • 6. Mieda M., Yanagisawa M.: Sleep, feeding and neuropeptides: roles of orexins and orexin receptors. Curr. Opin. Neurobiol. 2002; 12: 339-345.
  • 7. de Miguel M.J., Burrell MA: Immunocytochemical detection of orexin A in endocrine cells of the developing mouse gut. J. Histochem. Cytochem. 2002; 50: 63-69.
  • 8. Switońska M.M., Kaczmarek P., Malendowicz L.K., Nowak K.W: Orexins and adipoinsular axis function in the rat. Regul. Pept. 2002; 104: 69-73.
  • 9. Szekely M., Petervari E., Balasko M. i wsp.: Effects of orexins on energy balance and thermoregulation. Regul. Pept. 2002; 104: 47-53.
  • 10. Wren A.M., Small C.J., Abbott C.R. i wsp.: Ghrelin causes hyperphagia and obesity in rats. Diabetes 2001; 50: 2540-2547.
  • 11. Backberg M., Hervieu G., Wilson S., Meister B.: Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake. Eur. J. Neurosci. 2002; 15: 315-328.
  • 12. Willie J.K., Chemelli R.M., Sinton Ch.M., Yanagisawa M.: To eat or to sleep? Orexins in the regulation of feeding and wakefulness. Annu. Rev. Neurosci. 2001; 24: 429-458.
  • 13. Liu X.H., Morris R., Spiller D. i wsp.: Orexin A preferentially excites glucose-sensitive neurons in the lateral hypothalamus of the rat in vitro. Diabetes 2001; 50:2431-2437.
  • 14. Briski K.P, Sylvester P.W: Hypotalamic orexin-A-immunopositive neurons express Fos in response to central glucopenia. Neuroreport. 2001; 12: 531-534.
  • 15. Orlando G., Brunetti L., Di Nisio C. i wsp.: Effects of cocaine- and amphetamine-regulated transcript peptide, leptin and orexins on hypothalamic serotonin release. Eur. J. Pharmacol. 2001; 430: 269-272.
  • 16. Blanco M., Lopez M., Garcia-Caballero T. i wsp.: Cellular localization of orexin receptors in human pituitary. J. Clin. Endocrinol. Metab. 2001; 86; 1616-1619.
  • 17. KojimaM., Hosoda H., Date Y. iwsp.: Ghrelin is agrowth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
  • 18. Murray Ch.D., Kamm MA, Bloom S.R., Emmanuel A.V: Ghrelin for the gastroenterologist: history and potential. Gastroenterology 2003; 125: 1492-1502.
  • 19. Lazarczyk MA, LazarczykM., Grzela T: Ghrelin: a recently discovered gut-brain peptide (reviev). Int. J. Mol. Med. 2003; 12: 279-287.
  • 20. Date Y., Ueta Y., Yamashita H. i wsp.: Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. USA 1999; 96: 748-753.
  • 21. Broglio F., Arvat E., Benso A. i wsp.: Ghrelin a natural GH secretagogue produced by the somach, induces hyperglycemia and reduces insulin secretion in humans. J. Clin. Endocrinol. Metab. 2001; 86: 5083-5086.
  • 22. Starzomska M.: Z historii psychiatrii: anorexia nervosa jako optymalne zachowanie w socjokulturowym kontekście. Pschiatr. Pol. 2001; 35: 669-679.
  • 23. Arihara Z., Takahashi K., Murakami O. i wsp.: Immunoreactive orexin-A in human plasma. Peptides 2001; 22: 139-142.
  • 24. Adam JA, Menheere P.P, van Dielen F.M. i wsp.: Decreased plasma orexin-A levels in obese individuals. Int. J. Obes. Relat. Metab. Disord. 2002; 26: 274-276.
  • 25. Inui A.: Eating behavior in anorexia nervosa - an excess of both orexigenic and anorexigenic signalling? Mol. Psychiatry 2001; 6: 620-624.
  • 26. Ariyasu H., Takaya K., Tagami T i wsp.: Stomach is a major source of circulating ghrelin and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J. Clin. Endocrinol. Metab. 2001; 86: 4753-4758.
  • 27. Cummings D.E., Purnell J.O., Frayo R.S. i wsp.: A pre-prandial rise in plasma ghrelin levels suggests a role in meal initiation in humans. Diabetes 2001; 50: 1714-1719.
  • 28. Otto B., Cuntz U., Fruehauf E. i wsp.: Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa. Eur. J. Endocrinol. 2001; 145: 5-9.
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