Profile of HIV and Hepatitis B Virus Co-infected Patients Visiting Federal Teaching Hospital, Abakaliki (FETHA), Ebonyi State, Nigeria

• Authors: Okafor Collins Onyebuchi Okeke , Ovia Kenneth Ndidi , Emmanuel Chukwumbah , Nwachukwu Ogechukwu Blessing , Maria Okwudili Okata-Nwachukwu , Onu Euslar Nnenna
• Languages of publication: EN

Abstracts

EN

Information is very scarce on the co-infection of human immunodefficiency virus (HIV) with hepatitis-B virus (HBV) infection among patients receiving treatment for infectious diseases in Nigeria. 80 samples were analyzed in this study and were evaluated for the presence and qualitative detection of HIV and HBV surface antigen using a lateral chromatographic immunoassay kit (BC-ABON HIV, ABON HBsAg) among patients aged (11-74 years) attending Federal Teaching Hospital Abakaliki (FETHA), Nigeria. Twelve (15%) of the patients examined were seropositive for HIV, while ten (12.5 %) patients were HBsAg seropositive. A higher HIV seroprevalence was recorded in the females (20 %) than males (10 9%) among the patients. A slight higher HBsAg seroprevalence were observed in males (15 %) than females (10 %) with the highest prevalence of HBsAg occurring in the 11-20 and 51-60 years age group (16.67 %), followed by those of 41-50 years (12.5%). Results of the co-infection of HIV with HBV revealed that 5 (62.5 %) were seropositive for both HIV and HBV surface antigen with a considerably difference observed in male (10 %) than in female (2.5 %). Results confirmed the high endemicity of HBV infection among patients attending FETHA Ebonyi State, Nigeria and the significantly greater prevalence of HIV infection than HBV among infected patients.

Keywords

EN

HBV; HIV; hepatitis-B virus; human immunodefficiency virus

Discipline

• MICROBIOLOGY: MICROBIOLOGY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2025
• Volume: 59
• Pages: 109-121

Contributors

author

Okafor Collins Onyebuchi Okeke

• Department of Microbiology, Evangel University Akaeze, Ebonyi State, Nigeria

author

Ovia Kenneth Ndidi

• Department of Microbiology, Evangel University Akaeze, Ebonyi State, Nigeria

author

Emmanuel Chukwumbah

• Department of Science Labortory Technology, Federal Polytechnic, Oko, Anambra State, Nigeria

author

Nwachukwu Ogechukwu Blessing

• Department of Microbiology, Evangel University Akaeze, Ebonyi State, Nigeria

author

Maria Okwudili Okata-Nwachukwu

• Department of Science Labortory Technology, Akanu Ibiam Federal Polytechnic, Unwana, Ebonyi State, Nigeria

author

Onu Euslar Nnenna

• Department of Microbiology, Alex Ekwueme Federal University, Ndufu-Alike Ikwo, Ebonyi State, Nigeria

References

• [1] Adoga M. P., Gyar S. D., Pechulano S., Bashayi O. D., Emiasegen S. E,, Zungwe T., Iperepolu O. H., Agupugo C. and Agwale S. M. (2010). Hepatitis B virus infections in apparently healthy urban Nigerians: data from pre-vaccination tests. J Infect Dev Ctries. 4(6): 397–400
• [2] Ajuwon B. I., Yujuico I., Roper K., Richardson A., Sheel M. and Lidbury B. A. (2021). Hepatitis B virus infection in Nigeria: a systematic review and meta-analysis of data published between 2010 and 2019. BMC Infectious Diseases 21: 1120. https://doi.org/10.1186/s12879-021-06800-6
• [3] Cheng Z., Lin P. and Cheng N. (2021). HBV/HIV Coinfection: Impact on the Development and Clinical Treatment of Liver Diseases. Front. Med. 8: 713981
• [4] Dan-Nwafor C. C, Adeoye I, Aderemi K, Onuoha M, Adedire E, Bashorun A, Osunkwo D, Gidado S, Balogun M, Idris S, Ade-Yusuf I, Udom E. and Nguku P. (2021) Serological markers and risk factors associated with Hepatitis B virus infection among Federal Capital Territory prison inmates, Nigeria: Should we be concerned? PLoS ONE 16(3): e0248045. https://doi.org/10.1371/journal.pone.0248045
• [5] Drahel N. and Sterling R. K. (2014). Hepatitis B Virus-HIV Coinfection: Forgotten but Not Gone. Gastroenterolgy and Hepatology, 10(12): 780-788
• [6] Drosten, C., Nippraschk, T., Manegold, C., Meisel, H., Brixner, V., Roth W.K., Apedjinou, A and Gunther, S (2002).Prevalence of Hepatitis B Virus DNA in Anti- HBC-positive/HBsAg-negative Sera Correlates With HCV But Not HIV Sero-status. Journal Clinical Virology, 29: 59-68
• [7] Eke A. C., Eke A. U., Okafor C. I., Ezebialu I. U., and Ogbuagu C. (2011). Prevalence, correlates and pattern of hepatitis B surface antigen in a low resource setting. Virology Journal, 8: 12
• [8] Frank-Peterside N. and Ayodele M. B. O. (2016). Sero-prevalence of hepatitis B virus infection among HIV Co-infected patients in Port harcourt, Nigeria. New York Science Journal, 9(5): 4–8
• [9] Guan, R (2005).Treatment of Chronic Hepatitis B in HIV Co-Infected Patients. Medical Journal Malaysia, 30(3): 52-56
• [10] Ikpeme E. E., Etukudo O. M., and Ekrikpo U. E. (2013). Seroprevalence of HBV and HIV co-infection in children and outcomes following highly active antiretroviral therapy (HAART) in Uyo, South-South Nigeria. African Health Sciences, 13(13): 955–961
• [11] Jatau A., Sha’aban A., Gulma K. A., Shitu Z., Khalid G. M., Isa A., Wada A. S. and Mustapha M. (2021). The Burden of Drug Abuse in Nigeria: A Scoping Review of Epidemiological Studies and Drug Laws. Public Health Rev. 42: 1603960. https://www.doi/10.3389/phrs.2021.1603960.
• [12] Kramvis, A and Kew, M.C (2007). Epidemiology of hepatitis B virus in Africa, its genotypes and clinical associations of genotypes. Hepatol Res. 37(s1): S9–19
• [13] Lawal O. A., Bakarey A. S., Uche L. N., Udeze A. O. and Okonko I. O. (2009). Hepatitis B virus infection among prospective human immunodeficiency virus positive blood donors at two designated blood banks in ibadan, Nigeria. World Applied Science Journal, 7(10): 1269–1274
• [14] Mkpuma V. O., Agah M. V., Victor U. O., Okafor C. O. and Okoronkwo C. (2018). Prevalence of Opportunistic Fungal Infections among HIV Infected Patients Attending Antiretroviral Clinic of Federal Teaching Hospital, Abakaliki, Ebonyi State, Nigeria and the Susceptibility of the Fungal Isolates to Selected Conventional Antifungal Drug. World Journal of Medical Sciences 15 (3): 116-123
• [15] Modi A. A. and Feld J. J. (2007).Viral Hepatitis and HIV in Africa. AIDS Review, 9: 25-39
• [16] Mohammed Y., Sharif A. and. Dabo, N. (2015). Seroprevalence of HBsAg among patients with febrile illnessess in murtala muhammad specialist hospital, Kano, Nigeria. Bayero Journal of Pure and Applied Sciences, 8(1): 19–23
• [17] Nnakenyi I. D, Uchechukwu C., Nto-ezimah U. Prevalence of hepatitis B and C virus co-infection in HIV positive patients attending a health institution in southeast Nigeria. Afri Health Sci. 2020; 20(2): 579-586. https://doi.org/10.4314/ahs.v20i2.5
• [18] Okonko I. O., Soleye F. A., Amusan T. A., udeze A., Alli J. A., Ojezele M. O., Nwanze J. C. and Fadeyi A. (2010). Seroprevalence of HBsAg among patients in Abeokuta, South western Nigeria. Global Journal of Medical Research, 10 (2): 40–49
• [19] Okonko, I. O., Okerentugba P. O. and Akinpelu A. O. (2012). Prevalence of HBsAG among attendees of reproductive Journal of Tropical Medicine 5 family and health (ARFH) center in ibadan, southwestern Nigeria. American-Eurasian Journal of Scientific Research, 7(3): 100–105
• [20] Oladokun R. E., Adejokun E., Brown B. J. and Osinusi K. (2010). HIV/AIDS in 3 Generations: Case Series. Jouranl of the Interantional Association of Physicians in AIDS Care, 9(6): 353 -357. https://www.org/10.10.117/1545109710377659
• [21] Olokoba A., Salawu F., Danburam A., Olokoba L. B., Midala J. K., Badung L. H. and Olatinwi A. (2011). Hepatitis B virus infection amongst pregnant women in North-Eastern Nigeria- A call for action. Nigerian Journal of Clinical Practice, 14(1): 10–13. https://www.doi.org/10.4103/1119-3077.79232
• [22] Omotola A. C., Onoja B. A., and Agama J. (2020). Detection of Hepatitis B Surface Antigen among Febrile Patients in Ankpa, Kogi State, Nigeria. Journal of Tropical Medicine, Volume 2020, Article ID 5136785, 6 pages. https://doi.org/10.1155/2020/5136785
• [23] Orji C. J., Chime O. H. and Ndibuagu E. O. (2020). Vaccination status and prevalence of hepatitis B virus infection among health-care workers in a tertiary health institution, Enugu State, Nigeria. Proceedings of Singapore Healthcare, 29(2) 119–125. https://www.doi/ 10.1177/2010105820923681
• [24] Oti V. B., Mohammed I. H., Ibrahim Y., Ibrahim C., Orok I., Saje Y. Y., Ambrose A. A., Olotu M. (2021). Epidemiologic Survey of HBV, HCV and HIV Infections in a Pregnant Women Population in Central Nigeria: A Cross-Sectional Study. J Infect Dis Epidemiol, 7: 194. https://www.doi.org/10.23937/2474-3658/1510194
• [25] Sirisena N. D., Njoku M. O., Idoko J., Isamade E., Barau C., Jelpe D., Zamani A., Otowo, S. (2002). Carriage Rate of Hepatitis-B Surface Antigen (HbsAG) In An Urban Community in Jos, Plateau State, Nigeria. Journal of Medicine 9: 7-10
• [26] Telatela, S.P., Matee, M.I. & Munubhi, E.K. Seroprevalence of hepatitis B and C viral co-infections among children infected with human immunodeficiency virus attending the paediatric HIV care and treatment center at Muhimbili National Hospital in Dar-es-Salaam, Tanzania. BMC Public Health 7, 338 (2007). https://doi.org/10.1186/1471-2458-7-338
• [27] Ugwuja E. and Ugwu N. (2010). Seroprevalence of hepatitis B surface antigen and liver function tests among adolescents in Abakaliki, South eastern Nigeria. International Journal of Tropical Medicine, 6(2): 1-6
• [28] Uneke C. J., Ogbu O., Inyama P. U., Anyanwu G. A., Njoku M. O., Idoko J. H. (2005). Prevalence of hepatitis-B surface antigen among blood donors and human immunodeficiency virus-infected patients in Jos, Nigeria. Mem. Inst Oswaldo Cruz, Rio de Janeiro, 100(1): 13-16
• [29] Vernet G. and Tran N. (2006). The DNA-Chip technology as a new molecular tool for the detection of HBV mutants. Journal of Clinical Virology, 34 (S1): S49-S53

• Document Type: article