Full-text resources of PSJD and other databases are now available in the new Library of Science.
Visit https://bibliotekanauki.pl

PL EN


Preferences help
enabled [disable] Abstract
Number of results

Journal

2021 | 11 | 2 | 33-39

Article title

Quality of life patients treated with rituximab intravenous versus subcutaneous in B-cell lymphomas: results from outpatient Hematooncology Clinic in Lodz

Content

Title variants

Languages of publication

EN

Abstracts

EN
Introduction: Nowadays, rituximab is available both as intravenous (IV) and subcutaneous (SC) formulations. The aim of this study is to compare quality of life (QOL) of patients treated in Hematooncology Clinic in Lodz with B-cell nonHodgkin lymphoma (B-NHL) treated with rituximab IV and SC. Material and Methods: In 50 adult patients with B-NHL diagnosis we assessed QOL by three different questionnaries (EORTC QLQ-C30, FACT/ GOG-NTx and EQ-5D). We compared it between patients treated with rituximab IV and SC. Results: In comparison of general condition in EQ-5D-3L and EORTC QLQ-C30 questionnaire patients treated with rituximab SC felt statistically better than with IV administration (p<0.01). In SC group general health was evaluated for 72 while in IV for only 58,1. According to FACT/GOG-NTx questionnaire SC group had significantly better physical well-being. In SC group we observed statistically more complete responses (CR) 21 (88%) versus 17 (65%) in IV group. Moreover, trend was observed in emotional well-being in favor of SC treatment. Discussion: In our study we observed for the first time in the literature statistical difference in frequency of vomiting, nausea, and lack of appetite mentioned from our patients in questionnarie. It is very important that this findings were not published in any other study comparing SC and IV route od administration. Also looking at economic side of SC administration, this type of dosing. As a result it should be preferred form for B-cell lymphoma patients.

Discipline

Publisher

Journal

Year

Volume

11

Issue

2

Pages

33-39

Physical description

Contributors

  • Department of Experimental Hematology, Medical University of Lodz, Poland Copernicus Memorial Hospital
  • Medical University of Lodz, Poland
  • Medical University of Lodz, Poland
author
  • Medical University of Lodz, Poland
  • Department of Haematology, Copernicus Memorial Hospital, Lodz, Poland
  • Department of Experimental Hematology, Medical University of Lodz, Poland Copernicus Memorial Hospital

References

  • 1. Smith MR. Rituximab (monoclonal anti-CD20 antibody): mechanisms of action and resistance. Oncogene. 2003; 22: 7359-68.
  • 2. Coiffier B. Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Goupe d’Etudes des Lymphomes de l’Adulte. Blood. 2010; 116: 2040-5.
  • 3. Davies A, Berge C, Boehnke A et al. Subcutaneous Rituximab for the treatment of B-cell hematologic malignancies: a review of the scientific rationale and clinical development. Adv Ther. 2017; 34: 2210-31.
  • 4. Payandeh Z, Bahrami AA, Hoseinpoor R et al. The applications of anti-CD20 antibodies to treat various B cells disorders. Biomed Pharmacother. 2019; 109: 2415-26.
  • 5. Bookbinder LH, Hofer A, Haller MF et al. A recombinant human enzyme for enhanced interstitial transport of therapeutics. J Control Release. 2006; 11: 230-41.
  • 6. Mao CP, Brovarney MR, Dabbaghet K et al. Subcutaneous versus intravenous administration of rituximab: pharmacokinetics, CD20 target coverage and B-cell depletion in cynomolgus monkeys. PLoS One. 2013; 8: e80533.
  • 7. Davies A, Merli F, Mihaljevićet B et al. Efficacy and safety of subcutaneous rituximab versus intravenous rituximab for first-line treatment of follicular lymphoma (SABRINA): a randomised, open-label, phase 3 trial. Lancet Haematol. 2017; 4: e272-e82.
  • 8. De Cock E, Kritikou P, Sandoval M et al. Time Savings with Rituximab Subcutaneous Injection versus Rituximab Intravenous Infusion: A Time and Motion Study in Eight Countries. PLoS One. 2016; 11: e0157957.
  • 9. Delgado Sánchez O, Gutiérrez A, do Pazo F et al. Comparative Cost Analysis Of Intravenous And Subcutaneous Administration Of Rituximab In Lymphoma Patients. Clinicoecon Outcomes Res. 2019; 11: 695-701.
  • 10. Pivot X, Verma S, Fallowfield L et al; PrefHer Study Group. Efficacy and safety of subcutaneous trastuzumab and intravenous trastuzumab as part of adjuvant therapy for HER2-positive early breast cancer: Final analysis of the randomised, two-cohort PrefHer study. Eur J Cancer. 2017; 86: 82-90.
  • 11. Melichar B. PrefHer: finally addressing the preferences of her, too. Lancet Oncol. 2013; 14: 914-5.
  • 12. Lugtenburg P, Avivi I, Berenschot H et al. Efficacy and safety of subcutaneous and intravenous rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone in first-line diffuse large B-cell lymphoma: the randomized MabEase study. Haematologica. 2017; 102: 1913-22.
  • 13. Rummel M, Kim TM, Aversa F et al. Preference for subcutaneous or intravenous administration of rituximab among patients with untreated CD20+ diffuse large B-cell lymphoma or follicular lymphoma: results from a prospective, randomized, open-label, crossover study (PrefMab). Ann Oncol. 2017; 28: 836-42.
  • 14. Sanchez Delgado O, Gutiérrez A, do Pazo F et al. Comparative Cost Analysis Of Intravenous And Subcutaneous Administration Of Rituximab In Lymphoma Patients. Clinicoecon Outcomes Res. 2019; 11: 695-701.
  • 15. Rule S, Barreto WG, Briones J et al. Efficacy and safety of prolonged maintenance with subcutaneous rituximab in patients with relapsed or refractory indolent NHL: results of the phase III MabCute study. Hematol Oncol. 2019; 37(S2): 229-31.

Document Type

article

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.psjd-2984b366-b3b9-4ec4-9720-ba2fd8826c66
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.