Generating Organic Compounds by Retrosynthetic Pathway via Typical Corey’s Synthesis

• Authors: Chinonso Godwin Ononiwu , Onyekachi Oluchi Enwereuzo , Obinna Chigoziem Akakuru , Chukwudima Benaiah Ejiogu , Chinonso Uchenna Onumah , Chinedu Kingsley Achukee , Tobechukwu Nnamdi Umaefulam , Nkechi Nancy Abaekwume , Ozioma Udochukwu Akakuru
• Languages of publication: EN

Abstracts

EN

Several methods exist for the synthesis of alkanes including Corey’s synthesis, Wurtz reaction, reduction of alcohols and aldehydes, Kolbe’s electrolysis, hydrogenation of alkenes, and Grignard reaction. Among the available methods, the age-long Corey’s synthesis presents robust advantages of yielding symmetrical, unsymmetrical, straight chain and branched chain alkanes. Moreover, it allows of generating high yields of alkanes by utilizing primary alkyl halide and an array of lithium dialkyl copper ranging from primary, secondary to tertiary. Corey’s synthesis has also been implicated in the synthesis of various organic compounds such as (+)-taylorione, terminal alkynes, caribenol A, ketones, and aldehydes. In this work, an explanation of the general concept in the Corey’s synthesis is provided. Furthermore, specific examples of Corey’s reactions and modifications are discussed. Finally, an outlook into the benefits of the Corey’s synthesis in present-day organic synthesis is provided, which is expected to enhance the understanding of organic reaction mechanisms for the development of various organic compounds as drugs for treating diseases.

Keywords

EN

Corey’s synthesis; aldehydes; alkanes; alkynes; ketones; organic compounds; organic reaction mechanism

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2021
• Volume: 36
• Pages: 88-98

Contributors

author

Chinonso Godwin Ononiwu

• Department of Science Education, University of Nigeria, Nsukka, Enugu State, Nigeria

author

Onyekachi Oluchi Enwereuzo

• Department of Geography and Environmental Management, Imo State University, Owerri, Nigeria

author

Obinna Chigoziem Akakuru

• Department of Geology, Federal University of Technology, Owerri, Nigeria

author

Chukwudima Benaiah Ejiogu

• Department of Science Education, University of Nigeria, Nsukka, Enugu State, Nigeria

author

Chinonso Uchenna Onumah

• Department of Economics, Imo State University, Owerri, Nigeria

author

Chinedu Kingsley Achukee

• Department of Biochemistry, University of Calabar, Calabar, Nigeria

author

Tobechukwu Nnamdi Umaefulam

• Department of Crop Science and Technology, Federal University of Technology, Owerri, Nigeria

author

Nkechi Nancy Abaekwume

• Department of Social Science Education, University of Nigeria, Nsukka, Enugu State, Nigeria

author

Ozioma Udochukwu Akakuru

• Department of Pure and Applied Chemistry, University of Calabar, Calabar, Nigeria

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• Document Type: article