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2017 | 22 | 151-158
Article title

THE ADSORPTION OF SIMVASTATIN ON CHITOSANS IN AN IN VITRO PHARMACEUTICAL MODEL

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Abstracts
EN
In clinical practice for the treatment of obesity, several natural macromolecular compounds are used, whose operation is based on supporting weight loss. During the use of dietary supplements containing chitosan, disease sometimes occurs and treatment for this often comprises different therapeutic agents and antibiotics. The aim of our study was to determine the binding capacity of simvastatin to chitosan, which is found in dietary supplements promoting weight loss, depending on variable physicochemical factors in the gastrointestinal tract model. The phenomenon of adsorption of simvastatin was investigated by a static and dynamic pharmaceutical model (according to the Modified method of Polish Pharmacopoeia IX) simulating the conditions in vitro. The amount of bound drug is used to calculate the average percentage of the adsorbed dose. The obtained results showed that simvastatin is adsorbed by chitosan in the used pH ranges, and the binding capacity is dependent on the environmental pH, viscosity, the concentration of the drug, the type of chitosan and additional substances present in the gastrointestinal tract. The average adsorption of simvastatin in the system of chitosan-nutrients, depending on the pH of the medium, was in the range of 27 to 95%. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system), when the bioavailability of dietary supplement using chitosan was almost zero.
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Year
Volume
22
Pages
151-158
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Contributors
author
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland., jan.meler@umed.wroc.pl
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.
author
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.
  • Faculty of Pharmacy, Department of Pharmaceutical Technology, Wrocław Medical University, Borowska 211, 50-556 Wrocław, Poland.
References
  • [1] Edwards C.A., Blackburn N.A., Craigen L. et al.: Viscosity of food gums determined in vitro related to their hypoglycemic actions. Am. J. Clin. Nutr. 1987, 46, 72.
  • [2] Krotkiewski M.: Use of fibers in different weight reduction programs. [in:] Björntorp P., Kritchevsky D. (eds.): Dietary fiber and obesity. Alan R. Liss Inc., New York 1985. [3] Ni Mhurchu C., Dunshea-Mooij C.A., Bennett D., Rodgers, A.: Chitosan for overweight or obesity. Cochrane Database Syst. Rev. 2005, 3, 3. [4] Sumiyoshi M, Yoshiyuki K.: Low molecular weight chitosan inhibits obesity induced by feeding a high-fat diet long-term in mice. J. Pharm. Pharmacol. 2006, 58, 201–207.
  • [5] Sannan T., Kurita K., Iwakura Y.: Macromol. Chem.1975,176,7797.
  • [6] Richardson S.C.W, Kolbe H.V.J., Duncan R.: Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA Inter. l. Pharm. 1999, 178, 231.
  • [7] Polskie Towarzystwo Farmaceutyczne: Farmakopea Polska VIII. Warszawa: Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, 2008, s. 3491.
  • [8] Dzierżanowska D.: Antybiotykoterapia praktyczna. Wyd. 3. Bielsko-Biała: A-medica Press, 2001, s. 112.
  • [9] Meler J., Pluta J., Ulanski P., Krotkiewski M.: Fat – the binding capacity of of ninths – the modified and modified chitosans. In: Progress on Chemistry and Application of Chitin and its Derivatives. Vol. IX (ed.: H. Struszczyk), Polish Chitin Society, Łódź, 2003, pp. 12–136.
  • [10] Filipkowska U., Klimiuk E., Grabowski S., Siedlecka E.: Adsorption of reactive dyes by modified chitin from aqueous solutions. Pol. J. Environ. Stud. 2002, 11, 315–323.
  • [11] Rhazi M., Desbrieres J., Tolaimate A., Rinaudo M., Vottero P., Alagui A., El Meray M.: Influence of the nature of the metal ions on the complexation with chitosan. Application to the treatment of liquid waste. Eur. Polym. J. 2002, 38, 1523–1530.
  • [12] Meler J., Pluta J.: The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical patternelof digestive tract. In: Progress on Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, 2004, pp. 131–137, .
  • [13] Berthold A., Cremer K., Kreuter J.: Preparation and characterization of chitosan microspheres as drug carrier for prednisolone sodium phosphate as model for anti-inflammatory drugs. J. Control. Release. 1996, 39, 17–25.
  • [14] Sinha V.R., Singla A.K., Wadhawan S., Kaushik R., Kumria R., Bansal K., Dhawan S.: Chitosan microspheres as a potential carrier for drugs. Int. J. Pharm. 2004, 274, 1–33.
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article
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bwmeta1.element.psjd-23fd1951-d306-47f5-988a-8b74080fbb04
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