THE INFLUENCE OF A DENTAL FORMULATION PREPARED WITH CHITOSAN ON THE PHARMACEUTICAL AVAILABILITY OF CLOTRIMAZOLE

• Authors: Bożena Grimling , Jan Meler , Maria Szcześniak , Martyna Kocoń , Bożena Karolewicz , Adrianna Złocińska , Agata Górniak
• Languages of publication: EN

Abstracts

EN

The present work involves the development of a dental gel composition obtained on the basis of clotrimazole incorporated into chitosan in order to improve drug solubility. Solid dispersions were prepared by using two methods: grinding and kneading. The solid dispersion varied the ratio of chitosan to drug to increase the volume of the drug; the ratios were 5:5, 3:7, 2:8, 1:9. The mixtures were subjected to the dissolution rate of clotrimazole. The presence of chitosan improved the drug solubility; a better solubility from the solid dispersion prepared by the grinding method was obtained from the ratio of drug to polymer of 1+9. The rate of dissolution of clotrimazole was improved 17 times compared to the pure drug. Fourier transform infrared spectroscopy (both infrared and X-ray diffraction) revealed no new chemical structure of the tested connections and concluded that there was no interaction between the drug and the polymer in the test diffractions. Solid dispersions with the best parameters were used to prepare hydrogels, and the pharmaceutical availability of clotrimazole was analysed. The best properties were characterized by a hydrogel that was composed of the ratio of the amount of drug to polymer 5:5. The study demonstrated the availability of a pharmaceutical drug release at a therapeutic concentration in the first hour of the study. The use of the appropriate balance between clotrimazole and chitosan and the development of the hydrogel composition may affect the improvement of the drug solubility and may create the possibility of obtaining sustained or controlled release of the drug substance.

Keywords

EN

FTIR; carrier XRPD; chitosan; clotrimazole; hydrogel; solid dispersion

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2017
• Volume: 22
• Pages: 42-53

Contributors

author

Bożena Grimling

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

author

Jan Meler

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

author

Maria Szcześniak

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

author

Martyna Kocoń

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

author

Bożena Karolewicz

• Faculty of Pharmacy, Department of Pharmaceutical Technology, The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

author

Adrianna Złocińska

• Faculty of Pharmacy, Laboratory of Elemental Analysis and Structural Research The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

author

Agata Górniak

• Faculty of Pharmacy, Laboratory of Elemental Analysis and Structural Research The „Silesian Piasts” Memorial Medical University of Wroclaw 50-556 Wroclaw St. Borowska 211a, Poland

• Document Type: article