IN VITRO STUDIES OF ADSORPTION OF ERYTHROMYCIN ON CHITOSANS FROM DIETARY SUPPLEMENTS

• Authors: Jan Meler , Bożena Grimling , Maria Szcześniak , Paweł Biernat
• Languages of publication: EN EN

Abstracts

EN

In clinical practice, in the treatment of obesity, a plurality of natural high-molecular compounds are used, the activity of which supports weight loss. During the use of dietary supplements containing chitosan, illness sometimes develops and other therapeutic agents are applied as antibiotics The aim of our study was to determine the binding capacity of the antibiotic erythromycin depending on variable physicochemical factors, in the model of the gastrointestinal tract, by chitosans found in slimming dietary supplements Erythromycin adsorption phenomenon was studied by static and dynamic pharmaceutical model (according to the modified method of the Polish Pharmacopoeia) simulating in vitro conditions. The amount of bound drug was used to calculate the average percentage of the adsorbed dose. The results obtained show that erythromycin is adsorbed by chitosans at various pH ranges, and the binding capacity of the environment depends on the pH, viscosity and concentration of the antibiotic, as well as the chitosan and type and additional substances present in the gastrointestinal tract. The average level of the adsorption of erythromycin in the chitosan-nutrients system depends on the pH of the medium. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system).

Keywords

EN

Erythromycin; adsorption; chitosan

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Sieć Badawcza Łukasiewicz - Polskie Towarzystwo Chitynowe
• Journal: Progress on Chemistry and Application of Chitin and its Derivatives
• Year: 2014
• Volume: 19
• Pages: 119-123

Contributors

author

Jan Meler

• Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw

author

Bożena Grimling

• Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw

author

Maria Szcześniak

• Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw

author

Paweł Biernat

• Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw

References

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• 7. Meler J., Pluta J.; (2004) The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical pattern of digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, 131-137.

• Document Type: communication