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2014 | 19 | 119-123
Article title

IN VITRO STUDIES OF ADSORPTION OF ERYTHROMYCIN ON CHITOSANS FROM DIETARY SUPPLEMENTS

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Abstracts
EN
In clinical practice, in the treatment of obesity, a plurality of natural high-molecular compounds are used, the activity of which supports weight loss. During the use of dietary supplements containing chitosan, illness sometimes develops and other therapeutic agents are applied as antibiotics The aim of our study was to determine the binding capacity of the antibiotic erythromycin depending on variable physicochemical factors, in the model of the gastrointestinal tract, by chitosans found in slimming dietary supplements Erythromycin adsorption phenomenon was studied by static and dynamic pharmaceutical model (according to the modified method of the Polish Pharmacopoeia) simulating in vitro conditions. The amount of bound drug was used to calculate the average percentage of the adsorbed dose. The results obtained show that erythromycin is adsorbed by chitosans at various pH ranges, and the binding capacity of the environment depends on the pH, viscosity and concentration of the antibiotic, as well as the chitosan and type and additional substances present in the gastrointestinal tract. The average level of the adsorption of erythromycin in the chitosan-nutrients system depends on the pH of the medium. The highest amount of adsorption was noted above pH 7 (chitosan precipitated polymer forming the emulsion-gel system).
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Year
Volume
19
Pages
119-123
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Contributors
author
  • Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw, j.meler@umed.wroc.pl
  • Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw
  • Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw
  • Department of Drug Form Technology Faculty of Pharmacy Medical University of Wroclaw
References
  • 1. Meler J., Grimling B., Pluta J.; (2012) Studies of adsorption on chitosan Norfloxacin. Progress on Chemistry and Application of Chitin and Its Derivatives 17, 99-103.
  • 2. Polskie Towarzystwo Farmaceutyczne: Farmakopea Polska VIII. Warszawa: Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych, 2008,3491.
  • 3. Dzierżanowska D.; (2001) Antybiotykoterapia praktyczna. Wyd. 3. Bielsko-Biała: A-medica Press, 112.
  • 4. Meler J., Pluta J., Ulanski P. Krotkiewski M.; (2003) Fat- the binding capacity of of ninths - the modified and modified chitosans. In: Progress the Chemistry and Application of Chitin and its Derivatives. Vol. IX (ed.: H. Struszczyk), Polish Chitin Society, Lodz, 129-136.
  • 5. Filipkowska U., Klimiuk E., Grabowski S., Siedlecka E.; (2002) Adsorption of reactive dyes by modified chitin from aqueous solutions. Pol. J. Environ. Stud. 11, 315-323.
  • 6. Rhazi M., Desbrieres J., Tolaimate A., Rinaudo M., Vottero P., Alagui A., El Meray M.; (2002) Influence of the nature of the metal ions on the complexation with chitosan. Application to the treatment of liquid waste. Eur. Polym. J. 38,1523-1530, DOI: 10.1016/S0014-3057(02)00026-5.
  • 7. Meler J., Pluta J.; (2004) The effect of auxiliary substances the activity of lipase pancreatic biopharmaceutical pattern of digestive tract. In: Progress of Chemistry and Application of Chitin and its Derivatives. Vol. X (ed.: H. Struszczyk), Polish Chitin Society, Łódź, 131-137.
Document Type
communication
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bwmeta1.element.psjd-229738d8-454a-4f0a-abb5-a1ea842ab566
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