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2017 | 22 | 125-134
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In the present study, thin films based on the blends of chitosan (Ch) and hyaluronic acid (HA) with and without collagen (Coll) were characterised using tensile tests, attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) and thermogravimetric analysis (TGA). Ch/HA and Ch/HA/Coll polymer blends were prepared using the solvent evaporation technique. The interactions between polymer components in the binary and ternary blends were studied by FTIR analysis. Mechanical properties were studied and compared with those of simple polymer films. These results show that the addition of collagen into Ch/HA blends led to the increase of tensile strength and Young modulus. Moreover, it was found that the thermal stability of the Ch/HA binary blend significantly increased upon the addition of collagen.
Physical description
  • Nicolaus Copernicus University in Toruń, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Toruń, Poland,
  • Nicolaus Copernicus University in Toruń, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Toruń, Poland,
  • Nicolaus Copernicus University in Toruń, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Toruń, Poland,
  • Nicolaus Copernicus University in Toruń, Faculty of Chemistry, Department of Chemistry of Biomaterials and Cosmetics, Gagarin 7, 87-100 Toruń, Poland,
  • [1] Liu H, Yin Y, Yao K, Ma D, Cui L, Cao Y; (2004) Influence of the concentration of hyaluronic acid on the properties and biocompatibility of Cs-Gel-HA membranes, Biomaterials 25, 3523–3530.DOI: 10.1016/j.biomaterials.2003.09.102
  • [2] Rinaudo M; (2008) Review: Main properties and current applications of some polysaccharides as biomaterials. Polym Int 57, 397–430. DOI: 10.1002/pi.2378
  • [3] Chung TW, Chang YL; (2010) Silk fibroin/chitosan–hyaluronic acid silk fibroin scaffolds for tissue engineering: promoting cell proliferations in vitro. J Mater Sci: Mater Med 21, 1343–1351. DOI: 10.1007/s10856-009-3876-0
  • [4] Schanté CE, Zuber G, Herlin C, Vandamme TE; (2011) Chemical modifications of hyaluronic acid for a broad range of biomedical applications. Carbohydr Polym 85, 469–489. DOI: 10.1016/j.carbpol.2011.03.019
  • [5] Sionkowska A; (2011) Current research on the blends of natural and synthetic polymers as new biomaterials: Review. Prog Polym Sci 36, 1254–1276. DOI: 10.1016/j.progpolymsci.2011.05.003
  • [6] Chandra R, Rustgi R; (1998) Biodegradable polymers. Prog Polym Sci 23, 1273–1335. DOI: 10.1016/S0079-6700(97)00039-7
  • [7] Aroguz AZ, Baysal BM; (2006) Miscibility studies on blends of poly(phenylene oxide)/brominated polystyrene by viscometry. Eur Polym J 42, 311–315. DOI: 10.1016/j.eurpolymj.2005.07.012
  • [8] Pawde SM, Deshmukh K, Parab S; (2008) Preparation and characterization of poly(vinyl alcohol) and gelatin blend films. J Appl Polym Sci 109, 1328–1337. DOI: 10.1002/app.28096
  • [9] Katti KS, Katti DR, Dash R; (2008) Synthesis and characterization of a novel chitosan/montmorillonite/hydroxyapatite nanocomposite for bone tissue engineering. Biomed Mater 3, 1–12. DOI: 10.1088/1748-6041/3/3/034122
  • [10] Venkata Prasad C, Sudhakar H, Yerri Swamy B, Venkata Reddy G, Reddy CLN, Suryanarayana C, Prabhakar MN, Subha MCS, Chowdoji Rao K; (2011) Miscibility studies of sodium carboxymethylcellulose/poly(vinyl alcohol) blend membranes for pervaporation dehydration of isopropyl alcohol. J Appl Polym Sci 120, 2271–2281. DOI: 10.1002/app.33418
  • [11] Li X, Nan KH, Shi S, Chen H; (2012) Preparation and characterization of nano-hydroxyapatite/chitosan cross-linking composite membrane intended for tissue engineering. Int J Biol Macromol 50, 43–49. DOI: 10.1016/j.ijbiomac.2011.09.021
  • [12] Fan Z, Zhang F, Liu T, Zuo BQ; (2014) Effect of hyaluronan molecular weight on structure and biocompatibility of silk fibroin/hyaluronan scaffolds. Int J Biol Macromol 65, 516–523. DOI: 10.1016/j.ijbiomac.2014.01.058
  • [13] Li Y, Qing S, Zhou J, Yang G; (2014) Evaluation of bacterial cellulose/hyaluronan nanocomposite biomaterials. Carbohydr Polym 103, 496–501. DOI: 10.1016/j.carbpol.2013.12.059
  • [14] Rafique A, Zia KM, Zuber M, Tabasum S, Rehman S; (2016) Chitosan functionalized poly(vinyl alcohol) for prospects biomedical and industrial applications: A review. Int J Biol Macromol 87, 141–154.
  • [15] Arjmandi R, Hassan A, Haafiz MKM, Zakaria Z, Islam M; (2016) Effect of hydrolysed cellulose nanowhiskers on properties of montmorillonite/polylactic acid nanocomposites. Int J Biol Macromol 82, 998–1010. DOI: 10.1016/j.ijbiomac.2015.11.028
  • [16] Sionkowska A, Wiśniewski M, Skopińska J, Kennedy CJ, Wess TJ; (2004) Molecular interactions in collagen and chitosan blends. Biomaterials 25, 795–801. DOI: 10.1016/S0142-9612(03)00595-7
  • [17] Meyers MA, Chen P, Lin AY, Seki Y; (2008) Biological materials: Structure and mechanical properties. Prog Mat Sci 53, 1–206. DOI: 10.1016/j.pmatsci.2007.05.002
  • [18] Parenteau-Bareil R, Gauvin R, Berthod F; (2010) Collagen-based biomaterials for tissue engineering applications. Materials 3, 1863–1887. Doi: 10.3390/ma3031863
  • [19] Ferreira AM, Gentile P, Chiono V, Ciardelli G; (2012) Collagen for bone tissue regeneration. Acta Biomater 8, 3191–3200. DOI: 10.1016/j.actbio.2012.06.014
  • [20] Silvipriya KS, Krishna Kumar K, Bhat AR, Dinesh Kumar B, John A, Lakshmanan P; (2015) Collagen: Animal sources and biomedical application. J Appl Pharm Sci 5, 123–127. DOI: 10.7324/JAPS.2015.50322
  • [21] Patterson TJ, Siew R, Herring SW, Lin ASP, Guldberg R, Stayton PS; (2010) Hyaluronic acid hydrogels with controlled degradation properties for oriented bone regeneration. Biomaterials 31, 6772–6781. DOI: 10.1016/j.biomaterials.2010.05.047
  • [22] Rinaudo M; (2006) Chitin and chitosan: Properties and applications. Prog Polym Sci 31, 603–632. DOI: 10.1016/j.progpolymsci.2006.06.001
  • [23] Kenne L, Gohil S, Nilsson EM, Karlsson A, Ericsson D, Kenne AH, Nord LI; (2013) Modification and cross-linking parameters in hyaluronic acid hydrogels—Definitions and analytical methods. Carbohydr Polym 91, 410–418. DOI: 10.1016/j.carbpol.2012.08.066
  • [24] Collins MN, Birkinshaw C; (2013) Hyaluronic acid based scaffolds for tissue engineering—A review. Carbohydr Polym 92, 1262–1279. DOI: 10.1016/j.carbpol.2012.10.028
  • [25] Polexe RC, Delair T; (2013) Elaboration of stable and antibody functionalized positively charged colloids by polyelectrolyte complexation between chitosan and hyaluronic acid. Molecules 18, 8563–8578. DOI: 10.3390/molecules18078563
  • [26] Mathews S, Bhonde R, Gupta PK, Totey S; (2011) A novel tripolymer coating demonstrating the synergistic effect of chitosan, collagen type 1 and hyaluronicacid on osteogenic differentiation of human bone marrow derived mesenchymal stem cells. Biochem Biophys Res Commun 414, 270–276.
  • [27] Wu Y, Hu Y, Cai J, Ma S, Wang X; (2008) Coagulation property of hyaluronic acid–collagen/chitosan complex film. J Mater Sci: Mater Med 19, 3621–3629. DOI: 10.1007/s10856-008-3477-3
  • [28] Lin YC, Tan FJ, Marra KG, Jan SS, Liu DCh; (2009) Synthesis and characterization of collagen/hyaluronan/chitosan composite sponges for potential biomedical applications. Acta Biomater 5, 2591–2600. DOI: 10.1016/j.actbio.2009.03.038
  • [29] Lewandowska K, Sionkowska A, Grabska S; (2015) Influence of the intermolecular interaction on physico-chemical properties of chitosan/hyaluronic acid blends. Progress on chemistry and application of chitin and its derivatives vol. XX, pp. 170–176. DOI: 10.15259/PCACD.20.16
  • [30] Lewandowska K, Sionkowska A, Grabska S; (2015) Chitosan blends containing hyaluronic acid and collagen. Compatibility behaviour. J Mol Liq 212, 879–884. DOI: 10.1016/j.molliq.2015.10.047
  • [31] Lewandowska K, Sionkowska A, Grabska S, Kaczmarek B, Michalska M; (2016) The miscibility of collagen/hyaluronic acid/chitosan blends investigated in dilute solutions and solids. J Mol Liq 220, 726–730. DOI: 10.1016/j.molliq.2016.05.009
  • [32] Sionkowska A, Lewandowska K, Michalska M, Walczak M; (2016) Characterization of silk fibroin 3D composites modified by collagen. J Mol Liq 215, 323–327. DOI: 10.1016/j.molliq.2015.12.047
  • [33] Polish Norm PN-81/C-89034 (ISO 527-1 i 527-2).
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