Tyrosine kinase inhibitors – should we worry about cardiovascular complications?

• Authors: Katarzyna Styczkiewicz , Dariusz Sawka , Marek Styczkiewicz
• Languages of publication: EN

Abstracts

EN

Small-molecular tyrosine kinase inhibitors constitute an effective therapeutic option in patients with hematologic malignancies and solid tumours. On the other hand, the significance of cardiovascular adverse events associated with their use is often emphasised. The events include arterial hypertension, heart failure, coronary disease/acute coronary syndromes, and long QT syndrome. The paper discusses the underlying mechanisms behind cardiovascular events associated with the treatment that involves tyrosine kinase inhibitors, and presents preventive and therapeutic options available in clinical practice. Awareness of the potential cardiovascular complications, regular follow-up, early diagnosis and initiation of appropriate treatment, combined with close collaboration with cardiology specialists, may enhance the benefits of long-term TKI therapy.

Keywords

EN

anti-angiogenic therapy; cardiotoxicity; cardiovascular events; small-molecular tyrosine kinase inhibitors

Discipline

• MEDICINE: MEDICINE

• Publisher: Medical Education
• Journal: OncoReview
• Year: 2017
• Volume: 7
• Issue: 2
• Pages: 70-77

Contributors

author

Katarzyna Styczkiewicz

• Cardiology Department, Brzozow Hospital, Subcarpathian Cancer Center, Brzozow, Poland

author

Dariusz Sawka

• Chemotherapy Department, Brzozow Hospital, Subcarpathian Cancer Center, Brzozow, Poland

author

Marek Styczkiewicz

• Cardiology Department, Brzozow Hospital, Subcarpathian Cancer Center, Brzozow, Poland

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• Document Type: article