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2019 | 132 | 35-51
Article title

In silico study by using ProTox-II webserver for oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling and stress response pathways of synthetic pyrethroids

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EN
Till date, it is well-known that synthetic pyrethroids are safe to mammal but toxic to non-mammals. The present objective was an in silico study to detect oral acute toxicity, organ toxicity, immunotoxicity, genetic toxicity endpoints, nuclear receptor signalling, and stress response pathways of common synthetic pyrethroids by using ProTox-II webserver. The chemical compounds especially different synthetic pyrethroids such as pyrethrin I, Cinerin I and Jasmolin I (esters of Chrysanthemic acid), Pyrethrin-II, Cinerin II and Jasmolin II (Esters of Pyrethric acid), type I pyrethroids (esters without alpha-cyano group) such as allethrin, resmethrin, permethrin and bifenthrin and type II pyrethroids (esters with alpha-cyano group) such as fenvalerate, cyhalothrin, cypermethrin and deltamethrinwere selected from available literature. ProTox-II webserver was used for toxicological assessment in organism, organs, cell and gene level along with molecular mechanisms of toxicity. The predictive results for the toxicity of common synthetic pyrethroids compounds, Deltamethrin showed highly toxic compound among 14 compounds as fatal if swallowed as class II followed by Cypermethrin, Cyhalothrin, Bifenthrin, Resmethrin, Fenvalerate and Permethrin but hepatotoxic potential was only Deltamethrin and Fenvalerate while immunotoxic was obtained Permethrin. On the other hand, none of the compounds were obtained cytotoxic and carcinogenic but 9 compounds viz. Pyrethrin I, II Cinerin I, II, Jasmolin I, II, Allethrin, Resmethrin and Permethrin were observed mutagenic active. In case of NR signalling pathways, all compounds were inactive but eight compounds such as Pyrethrin I, II, Cinerin I, II, Jasmolin I, II, Allethrin and Resmethrin were obtained nrf2/ARE and HSE active while MMP active compounds were obtained Fenvalerate, Cyhalothrin and Deltamethrin respectively. For p53 and ATAD5 parameters, all fourteen compounds such as were obtained inactive. In conclusion, the present predictive results are suitable for academician, researchers, industries, etc. those who are making drugs and environmental chemicals. This web server helps faster screening of large numbers of compounds within short duration and no animal testing. This present in silico study easily detects toxin(s), which can be validated in future through in vitro and in vivo experimental assay.
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Year
Volume
132
Pages
35-51
Physical description
Contributors
  • Department of Environmental Science, University of Calcutta, 35 Ballygunge Circular Road, Kolkata – 700019, India
author
  • Department of Environmental Science, University of Calcutta, 35 Ballygunge Circular Road, Kolkata – 700019, India
  • Department of Botany, Serampore College, University of Calcutta, 8 William Carey Road, Serampore – 712201, West Bengal, India
  • Department of Biological Science, Seacom Skills University, Kendradangal, Shantiniketan, Birbhum – 731236, West Bengal, India
References
  • [1] Adelsbach TL, Tjeerdema RS, Chemistry and fate of fenvalerate and esfenvalerate. Reviews of Environmental Contamination and Toxicology 176 (2003) 137-154
  • [2] Rehman H, Aziz AT, Saggu S, Abbas ZK, Mohan A, Ansari AA, Systematic review on pyrethroid toxicity with special reference to deltamethrin. Journal of Entomology and Zoology Studies 2(5) (2014) 01-06
  • [3] Patel M, Patil P, Synthetic pyrethroids: Toxicity and metabolism. IOSR Journal of Agriculture and Veterinary Science 9(10 Ver. I) (2016) 55-60
  • [4] Elliott M, Janes MM, Synthetic pyrethroids – A new class of insecticide. Chem Soc Rev. 7 (1978) 473-505
  • [5] Roy NK, Chemistry of Pesticides, CBS Publishers and Distributors, New Delhi, India, 2002
  • [6] Soderlund DM, Clark JM, Sheets LP, Mullin LS, Piccirillo VJ, Sargent D, Stevens JT, Myra, Mechanisms of pyrethroid neurotoxicity: implications for cumulative risk assessment. Toxicology 171(1) (2002) 3-59
  • [7] Werner I, Geist J, Okihiro M, Rosenkranz P, Hinton DE, Effects of dietary exposure to the pyrethroid pesticide esfenvalerate on medaka (Oryzias latipes). Marine Environmental Research 54(3-5) (2002) 609-614
  • [8] de Assis HCDS, Nicareta L, Salvo LM, Klemz C, Truppel JH, Calegari R, Biochemical biomarkers of exposure to deltamethrin in freshwater fish, Ancistrus multispinis. Brazilian Archives of Biology and Technology 52(6) (2009) 1401-1407
  • [9] Kaviraj A, Gupta A, Biomarkers of type II synthetic pyrethroid pesticides in freshwater fish. BioMed Research International 2014 (2014) Article ID 928063 doi.org/10.1155/2014/928063
  • [10] Drwal MN, Banerjee P, Dunkel M, Wettig MR, Preissner R, ProTox: a web server for the in silico prediction of rodent oral toxicity. Nucleic Acids Research 42 (2014) W53-W58
  • [11] Banerjee P, Eckert AO, Schrey AK, Preissner R, ProTox-II: a webserver for the prediction of toxicity of chemicals. Nucleic Acids Research 46 (2018) W257-W263
  • [12] Banerjee P, Siramshetty VB, Drwal MN, Preissner R, Computational methods for prediction of in vitro effects of new chemical structures. J Cheminformatics 29(8) (2016) 51
  • [13] Miyamato J, Degradation, metabolism and toxicity of synthetic pyrethroids. Environmental Health Perspectives 14 (1976) 15-28
  • [14] Zhang Z, Sun J, Chen S, Wu Y, He F, Levels of exposure and biological monitoring of pyrethroids in spraymen. British Journal of Industrial Medicine 48 (1991) 82-86
  • [15] Poonam S, Mysra J, Rambir S, Deltamethrin Toxicity: A Review. Indian Journal of Biological Studies & Research 2 (2013) 91-107
  • [16] Waheed MPA, Mohammed HSM, Fenvalerate induced Hepatotoxicity and its amelioration by quercetin. International Journal of PharmTech Research 4(4) (2012) 1391-1400
  • [17] Rjeibi I, Saad AB, Hfaiedh N, Oxidative damage and hepatotoxicity associated with deltamethrin in rats: The protective effects of Amaranthus spinosus seed extract. Biomedicine & Pharmacotherapy 84 (2016) 853-860
  • [18] Khalatbary AR, Ghabaee DNZ, Ahmadvand H, Amiri FT, Lehi ST, Deltamethrin-induced hepatotoxicity and virgin olive oil consumption: An experimental study.Iran J Med Sci. 42(6) (2017) 586-592
  • [19] Chrustek A, Hoły´nska-Iwan I, Dziembowska I, Bogusiewicz J, Wróblewski M, Cwynar A, Olszewska-Słonina D, Current research on the safety of pyrethroids used as insecticides. Medicina 54 (2018) 61 doi:10.3390/medicina54040061
  • [20] Gabbianelli R, Falcioni ML, Nasuti C, Cantalamessac F, Imada I, Inou M, Effect of permethrin insecticide on rat polymorphonuclear neutrophils. Chemico-Biological Interactions 182 (2009) 245-252
  • [21] Banerjee BD, Koner BC, Ray A, Immunotoxicity of Pesticides: Perspectives and trends. Ind J Exp Biol. 34 (1996) 723-733
  • [22] Cui W, Fang C, Quan Z, Zhuo F, Chronic toxicity and cytotoxicity of synthetic pyrethroid insecticide cis-bifenthrin. Journal of Environmental Sciences 21 (2009) 1710-1715
  • [23] Herrera A, Laborda E, Mutagenic activity in synthetic pyrethroids in Salmonella typhimurium. Mutagenesis 3(6) (1988) 509-514
  • [24] Pluijmen M, Drevon C, Montesano R, Malaveille C, Hautefeuille A, Bartsch H, Lack of mutagenicity of synthetic pyrethroids in Salmonella typhimurium strains and in V79 Chinese hamster cells. Mutation Research 137 (1994) 7-15
  • [25] Cabral JRP, Galendo D, Laval M, Lyandrat N, Carcinogenicity studies with Deltamethrin in mice and rats. Cancer Letters 49(2) (1990) 147-152
  • [26] Du G, Shen O, Sun H, Fei J, Lu C, Song L, Xia Y, Wang S, Wang X, Assessing hormone receptor activities of pyrethroid insecticides and their metabolites in reporter gene assays. Toxicological Sciences 116(1) (2010) 58-66
  • [27] Kolodkin AN, Bruggeman FJ, Plant N, Moné MJ, Bakker BM, Campbell MJ, van Leeuwen JP, Carlberg C, Snoep JL, Westerhoff HV, Design principles of nuclear receptor signaling: how complex networking improves signal transduction. Mol Syst Biol. 6 (2010) 446 doi: 10.1038/msb.2010.102
  • [28] Simmons SO, Fan C-Y, Ramabhadran R, Cellular stress response pathway system as a sentinel ensemble in toxicological screening. Toxicological Sciences 111(2) (2009) 202-225
  • [29] Kang KW, Lee SJ, Kim SG, Molecular mechanism of nrf2 activation by oxidative stress. Antioxid Redox Signal. 7 (2005) 1664-1673
  • [30] Kensler TW, Wakabayashi N, Biswal S, Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 47 (2007) 89-116
  • [31] Voellmy R. Transduction of the stress signal and mechanisms of transcriptional regulation of heat shock/stress protein gene expression in higher eukaryotes. Crit Rev Eukaryot Gene Expr. 4 (1994) 357-401
  • [32] Boellmann F, Guettouche T, Guo Y, Fenna M, Mnayer L, Voellmy R, DAXX interacts with heat shock factor 1 during stress activation and enhances its transcriptional activity. Proc Natl Acad Sci USA. 101 (2004) 4100-4105
  • [33] Voellmy R, Boellmann F, Chaperone regulation of the heat shock protein response. Adv Exp Med Biol. 594 (2007) 89-99
  • [34] Hill S, Sataranatarajan K, Remmen HV, Role of signaling molecules in mitochondrial stress response. Front Genet. 9 (2018) 225 doi:10.3389/fgene.2018.00225
  • [35] Parikh VS, Morgan MM, Scott R, Clements LS, Butow RA, The mitochondrial genotype can influence nuclear gene expression in yeast. Science 235(4788) (1987) 576-580
  • [36] Meyer JN, Hartman JH, Mello DF, Mitochondrial toxicity. Toxicological Sciences 162(1) (2018) 15-23
  • [37] Richter U, Ng KY, Suomi F, Marttinen P, Turunen T, Jackson C, Suomalainen A, Vihinen H, Jokitalo E, Nyman TA, Isokallio MA, Stewart JB, Mancini C, Brusco A, Seneca S, Lombès A, Taylor RW, Battersby BJ, Mitochondrial stress response triggered by defects in protein synthesis quality control. Life Sci Alliance 2(1) (2019) e201800219 doi:10.26508/ lsa.201800219
  • [38] Ishii H, Inageta T, Mimori K, Saito T, Sasaki H, Isobe M, Mori M, Croce CM, Huebner K, Ozawa K, Furukawa Y, Frag1, a homolog of alternative replication factor C subunits, links replication stress surveillance with apoptosis. Proc Natl Acad Sci USA. 102 (2005) 9655-9660
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YADDA identifier
bwmeta1.element.psjd-20651aad-4020-4688-9147-f483089a0267
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