PL EN


Preferences help
enabled [disable] Abstract
Number of results
2019 | 123 | 258-264
Article title

Synthesis and characterization of 2-(methylthio)-6-oxo-6H-chromeno[3,4-e]pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives

Content
Title variants
Languages of publication
EN
Abstracts
EN
Some new 2-(methylthio)-6-oxo-6H-chromeno[3,4-e]pyrazolo[1,5-a]pyrimidine-3-carbonitrile derivatives Having coumarine nucleus were synthesized by novel synthetic rout from 4-chloro 3-carbaldehyde coumarine derivatives and previously prepared 5-amino-3-(methylthio)-1H-pyrazole-4-carbonitrile using methanol as a solvent and catalytic amount of glacial acetic acid. All the synthesised libraries were characterized by IR, NMR and mass spectral analysis.
Year
Volume
123
Pages
258-264
Physical description
Contributors
  • Matushri Virbaima Mahila Science & Home Science College, Kalawad road, Near Under Bridge, Rajkot - 360 007, Rajkot, Gujarat, India
  • Shree H.N. Shukla College of Science, B/H Marketing Yard, Bhichari, 360001, Rajkot, Gujarat, India
  • Matushri Virbaima Mahila Science & Home Science College, Kalawad road, Near Under Bridge, Rajkot - 360 007, Rajkot, Gujarat, India
References
  • [1] Jian J.C. (2007). Nitrogen- containing bicyclic hetroaryl compounds for the treatment of raf protein kinase-mediated diseases PCT. Int. Appl. WO 2007076092 A2 20070705
  • [2] Alexander, J. O.; Wheeler, G. R.; Hill, P. D.; Morris, M. P. Biochem. Pharmacol. 1966, 15, 881
  • [3] Elion, G. B.; Callahan, S.; Nathan, H.; Bieher, S.; Rundles, R.W.; Hitchings, G. H. Biochem. Pharmacol. 1963, 12, 85
  • [4] Earl, R. A.; Pugmire, R. J.; Revanker, G. R.; Townsend, L. B. J. Org. Chem. 1975, 40, 1822
  • [5] Novinson, T.; Bhooshan, B.; Okabe, T.; Revankar, G. R.; Wilson, H. R. J. Med. Chem. 1976, 19, 512
  • [6] Senga, K.; Novinson, T.; Wilson, H. R. J. Med. Chem. 1981, 24, 610
  • [7] Suzuki, M.; Iwasaki, H.; Fujikawa, Y.; Sakashita, M.; Kitahara, M.; Sakoda, R. Bioorg. Med. Chem. Lett. 2001, 11, 1285.
  • [8] Almansa, C. A.; Alberto, F.; Cavalcanti, F. L.; Gomez, L. A.; Miralles, A.; Merlos, M.; Garcia-Rafanell, J.; Forn, J. J. Med. Chem. 2001, 44, 350
  • [9] Novinson, T.; Hanson, R.; Dimmitt, M. K.; Simmon, L. N.; Robins, R. K.; O’Brien, D. E. J. Med. Chem. 1974, 17, 645
  • [10] Chen, C.; Wilcoxen, K. M.; Huang, C. Q.; Xie, Y.-F.; McCarthy, J. R.;Webb, T. R.; Zhu, Y.-F.; Saunders, J.; Liu, X.-J.; Chen, T.-K.; Bozigian, H.; Grigoriadis, D. E. J. Med. Chem. 2004, 47, 4787
  • [11] Huang, C. Q.; Wilcoxen, K. M.; Grigoriadis, D. E.; McCarthy, J. R.; Chen, C. Bioorg. Med. Chem. Lett. 2004, 14, 3943
  • [12] Chen, C.; Wilcoxen, K. M.; Huang, C. Q.; McCarthy, J. R.; Chen, T.; Grigoriadis, D. E. Bioorg. Med. Chem. Lett. 2004, 14, 3669
  • [13] Wustrow, D. J.; Capiris, T.; Rubin, R.; Knobelsdorf, A.; Akunne, H.; Davis, M. D.; MacKenzie, R.; Pugsley, T. A.; Zoski, K. T.; Heffner, T. G.; Wise, L. D. Bioorg. Med. Chem. Lett. 1998, 8, 2067
  • [14] Selleri, S.; Gratteri, P.; Costagli, C.; Bonaccini, C.; Costanzo, A.; Melani, F.; Guerrini, G.; Ciciani, G.; Costa, B.; Spinetti, F.; Martini, C.; Bruni, F. Bioorg. Med. Chem. 2005, 13, 4821
  • [15] Selleri, S.; Bruni, F.; Costagli, C.; Costanzo, A.; Guerrini, G.; Ciciani, G.; Costa, B.; Martini, C. Bioorg. Med. Chem. 2001, 9, 2661
  • [16] Selleri, S.; Bruni, F.; Costagli, C.; Costanzo, A.; Guerrini, G.; Ciciani, G.; Costa, B.; Martini, C. Bioorg. Med. Chem. 1999, 7, 2705
  • [17] Drizin, I.; Holladay, M. W.; Yi, L.; Zhang, H. Q.; Gopalakrishnan, S.; Gopalakrishnan, M.; Whiteaker, K. L.; Buckner, S. A.; Sullivan, J. P.; Carroll, W. A. Bioorg. Med. Chem. Lett. 2002, 12, 1481
  • [18] Altenbach, R.J.; Black, L.A.; Chang, S.; Cowart, M.D.; Faghih, R.; Gfesser, G.A.; Ku, Y.; Liu, H.; Lukin, K.A.; Nersesian, D.L.; Pu, Y.; Curtis, M.P.. U.S. Patent Appl. 256,309, 2005. Chem. Abstr. 2005, 144, 36332
  • [19] Kirkpatrick,W. E.; Okabe, T.; Hillyard, I.W.; Robin, R. K.; Dren, A. T. J. Med. Chem. 1977, 20, 386
Document Type
short_communication
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-1ef7b6f0-2473-466c-8af1-93342685b412
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.