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2017 | 83 | 216-223
Article title

Hypothesis of Selected Mendelian Traits Among Random Asian Population

Content
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Languages of publication
EN
Abstracts
EN
This discusses the prospects for understanding the genetic basis of few selected traits in humans. Phylogenetic analysis provides a path to identify genes and biological processes underlying any trait influenced by inheritance. We suggest that different experimental approaches should be undertaken for traits caused by common genetic variants versus those arising from rare genetic variants. We discuss the intellectual foundations of genetic of Mendelian traits in humans by examining the degree of freedom of four particular factors , namely toung rolling (1.307), hitchhiker’s tumb (3.22), widow’s peak (44.825) and mid digital hair (92.825).
Discipline
Year
Volume
83
Pages
216-223
Physical description
Contributors
  • Marine Biological Resources Division, National Aquatic Resources and Development Agency (NARA), No15, Crow Island, Colombo 15, Sri Lanka
References
  • [1] Nusbaum, B.P., and S. Fuentefria. 2009. Naturally occurring female hairline patterns. Dermatologic Surgery 35, 907-913.
  • [2] Smith, D.W., and M.M. Cohen. 1973. Widow's peak scalp-hair anomaly and its relation to ocular hypertelorism. Lancet 2, 1127-1128
  • [3] Robinson P.N. Deep phenotyping for precision medicine. Hum. Mutat. 2012, 33: 777-780.
  • [4] Deans A.R., Lewis S.E., Huala E., Anzaldo S.S., Ashburner M., Balhoff J.P., Blackburn D.C., Blake J.A., Burleigh J.G., Chanet B. Finding our way through phenotypes. PLoS Biol. 2015, 13, e1002033
  • [5] Blakemore A.I., Froguel P. Investigation of Mendelian forms of obesity holds out the prospect of personalized medicine. Ann. N Y Acad. Sci. 2010, 1214, 180-189.
  • [6] Blair D.R., Lyttle C.S., Mortensen J.M., Bearden C.F., Jensen A.B., Khiabanian H., Melamed R., Rabadan R., Bernstam E.V., Brunak S. A nondegenerate code of deleterious variants in Mendelian loci contributes to complex disease risk. Cell. 2013, 155, 70-80.
Document Type
short_communication
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-1c3cfc09-f758-492c-9508-575e22303d6e
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