Preferences help
enabled [disable] Abstract
Number of results
2016 | 37 | 202-219
Article title

QSAR modeling for prediction of acute toxicity and mutagenicity in different test models by established common phytochemicals present in Phyllanthus niruri

Title variants
Languages of publication
In globe, Pyllanthus niruri is a well-established medicinal herb studied by many researchers, grown widely in many parts of West Bengal. The present study was aimed to predict the acute toxicity as LC50 in Daphnia magna and Pimephales promelas and rat oral LD50 value as well as Ames mutagenicity by using QSAR modeling software, T.E.S.T. (Toxicity Estimation Software Tool) for commonly found phytochemicals in Pyllanthus niruri. In present works, the data were obtained for LC50, few phytochemicals were toxic to D. magna and P. promelas and also mutagenic but rat oral LD50 determined less toxic. The present QSAR modeling work is suggesting that more researches should be required through experimental as well as predictive study with other prescribed software to know the mechanisms of toxicity and mutagenicity for these combined form of phytochemicals after separating each natural chemical from extract prior to drugs development for therapeutic usage.
Physical description
  • Career Advancement Solutions, H2-120A/New, Benir Pole Road Maheshtala, Kolkata - 700141, India
  • Career Advancement Solutions, H2-120A/New, Benir Pole Road Maheshtala, Kolkata - 700141, India
  • Career Advancement Solutions, H2-120A/New, Benir Pole Road Maheshtala, Kolkata - 700141, India
  • [1] R.C. Agarwal, S. Pandey, Asian Pacific Journal of Cancer Prevention 10 (2009) 913-916.
  • [2] S. Das, K. Banerjee, A. Nandy, S.N. Talapatra, International Letters of Natural Sciences 29 (2014) 57-70.
  • [3] M. Adjanohoum, Man and the African medicinal plant. In Develop the natural environment. Revue du livre, Afrique-Océan Indien n Double 66-67, éd. Notre Librairie (1982) 51-58.
  • [4] K.M. Oksman-Caldentey, W.H. Barz, Plant biotechnology and transgenic plants. Marcel Dekker, New York, Basel (2002) 347-371.
  • [5] M.W. Iwu, A.R. Duncan, C.O. Okunji, New antimicrobials of plant origin. In: Perspectives on new crops and new uses, J. Janick, (ed.), ASHS Press, Alexandria, VA. (1999) 457-462.
  • [6] O.O. Aiyelaagbe, Fitoterapia 72 (2001) 544-546
  • [7] O.A. Aiyegoro, D.A. Akinpelu, A.J. Afolayan, A.I. Okoh, Journal of biological Sciences 8(2) (2008) 356-361.
  • [8] R.D. Girach, P.A. Siddioui, S.A. Khan, International Journal of Pharmacology 32 (1994) 274-283.
  • [9] M.L. Dhar, M.M. Dhar, B.N. Dhawan, B.N. Mehrotra, C. Ray, Indian Journal of Experimental Biology 6 (1968) 232-247.
  • [10] G. Bagalkotkar, S.R. Sagineedu, M.S. Saad, J. Stanslas, Journal of Pharmacy and Pharmacology 58 (2006) 1559-1570.
  • [11] R.N. Chopra, S.L. Nayar, I.C. Chopra, Glossary of Indian medicinal plants, CSIR, New Delhi. Ranchi, India, Catholic Press (1986).
  • [12] S.N. Talapatra, D. Misra, K. Banerjee, P. Banerjee, S. Swarnakar, International Journal of Advanced Research 3 (6) (2015) 225-240.
  • [13] S.N. Talapatra, A. Sarkar, International Journal of Advanced Research 3(7) (2015) 1424-1438.
  • [14] P. Banerjee, S.N. Talapatra, International Journal of Advanced Research 3(7) (2015) 225-243.
  • [15] USEPA (United States Environmental Protection Agency), T. E. S. T. Tool, User’s Guide for T.E.S.T, Version 4.1.; A Program to Estimate Toxicity from Molecular Structure, Cincinatti, OH, USA (2012).
  • [16] ChemIDplus, A Toxnet Database, U.S. National Library of Medicine (
  • [17] T.M. Martin, P. Harten, R. Venkatapathy, S. Das, D.M. Young, Toxicology Mechanisms and Methods 18 (2008) 251-266.
  • [18] H. Zhu, T.M. Martin, L. Ye, A. Sedykh, D.M Young, A. Tropsha, Chemical Research in Toxicology 22 (2009) 1913-1921.
  • [19] R. Harish, T. Shivanandappa, Food Chemistry 95 (2006) 180-185.
  • [20] A. Kumaran, R.J. Karunakaran, LWT 40 (2007) 344-352.
  • [21] L.U. Thompson, J.H. Yoon, D.J. Jenkins, T.M. Wolever, American Journal of Clinical Nutrition 39 (1984) 745-751.
  • [22] Y.Y. Lim, J. Murtijaya, LWT 40 (2007) 1664-1669.
  • [23] A.L. Normén, H.A. Brants, L.E. Voorrips, H.A. Andersson, P.A. van den Brandt, R.A. Goldbohm, The American Journal of Clinical Nutrition 74(1) (2001) 141-148.
  • [24] L.G. Valerio Jr., K.B. Arvidson, E. Busta, L. Barbara, B.L. Minnier, N.L. Kruhlak, R.D. Benz, Molecular Nutrition and Food Research 54 (2010) 186-194.
  • [25] A.M. Bode, Z. Dong, Cancer Prevention Research (Phila) 8(1) (2015) 1-8.
  • [26] K.B. Arvidson, L.G. Valerio, M. Diaz, R.F. Chanderbhan, Toxicological Mechanisms and Methods 18 (2008) 229-242.
  • [27] G.O. Ifere, A. Equan, K. Gordon, P. Nagappan, J.U. Igietseme, G.A. Ananaba, Cancer Epidemiology 34(4) (2010) 461-471.
  • [28] D.O. Kennedy, E.L. Wightman, Advances in Nutrition 2 (2011) 32-50.
  • [29] B. Syed Asad, M.M. Iqbal, M. Kiranmai, M. Ibrahim, Global Journal of Medical Research 12(6) (2012) 39-49.
  • [30] S. Husain, M.A. Alam, S. Ahmed, A. Quamri, M.A. Khan, Journal of Medicinal Plants Studies 2(6) (2014) 01-03.
  • [31] D.W. Unander, G.L. Webster, B.S. Blumberg, Journal of Ethnopharmacology 34 (1991) 97-133.
  • [32] J.B. Calixto, R.A. Yunes, A.S. Neto, R.M. Valle, G.A. Rae, Brazilian Journal of Medical and Biological Research 17 (1984) 313-321.
  • [33] P. S. Venkateswaran, I. Millman, B.S. Blumberg, Effects ofan extract from Phyllanthus niruri on Hepatitis B and woodchuckhepatitis viruses. In vitro and in vivo studies. Proceedings of the National Academy of Sciences USA 84 (1987) 274-278.
  • [34] Kumar NVR, Joy KL, Kuttan G, Ramsewak RS, Nair MG, Kuttan R., Journal of Ethnopharmacology 81(1) (2002) 17-22.
Document Type
Publication order reference
YADDA identifier
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.