Anticancer and Antioxidant Phytochemicals as Speed Breakers in Inflammatory Signaling

• Authors: Peace Abiodun Olajide , Oluwatosin Adefunke Adetuyi , Oluwakemi Semiloore Omowumi , Babatunde Oluwafemi Adetuyi
• Languages of publication: EN

Abstracts

EN

A causal association between inflammation and cancer has long been suspected. Multiple lines of compelling evidence from clinical, epidemiologic and laboratory studies support that inflammation plays a critical role in the promotion and progression stages of carcinogenesis. Recent progress in our understanding of the molecular biology of cancer highlights the intracellular signal transduction network, including that involved in mediating the inflammatory response, which often functions abnormally during carcinogenesis. One of the key players in inflammatory signaling is cyclooxygenase-2 (COX-2). Aberrant upregulation of COX-2 is frequently observed in various precancerous and malignant tissues. This seminar write-up highlights the cancer preventive effects of some anti-inflammatory phytochemicals derived from edible plants, and their underlying molecular mechanisms with a focus on representative transcription factors and upstream kinases responsible for COX-2 induction.

Keywords

EN

COX-2; Cancer; Inflammation; Phytochemicals

Discipline

• BIOCHEMISTRY: BIOCHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2022
• Volume: 44
• Pages: 231-259

Contributors

author

Peace Abiodun Olajide

• Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

author

Oluwatosin Adefunke Adetuyi

• Department of Biochemistry, Osun State University, Osogbo, Nigeria

author

Oluwakemi Semiloore Omowumi

• Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

author

Babatunde Oluwafemi Adetuyi

• Department of Natural Sciences, Faculty of Pure and Applied Sciences, Precious Cornerstone University, Ibadan, Oyo State, Nigeria

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