Novel Synthesis, spectral, characterization of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole and its applications of molecular docking, anticancer activity

• Authors: E. Dhineshkumar , M. Arockia doss , D. Uma
• Languages of publication: EN

Abstracts

EN

In the present study of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole 1 was synthesized. The synthesized imidazole compound 1 has been characterized by FT-IR, 1H, 13C NMR and ESI-Mass spectral studies. Molecular docking is also performed in order to explain the over-expression of estrogen receptor in 70% of liver cancer. The imidazole scaffold is a privileged scaffold for exploration of anticancer agents. The objective of the present study is to evaluate the anticancer activity of imidazole 1 in human liver cancer cell lines HepG2.

Keywords

EN

HepG2; Imidazole; cytotoxicity; molecular docking

Discipline

• CHEMISTRY: CHEMISTRY

• Publisher: Scientific Publishing House „DARWIN”
• Journal: World News of Natural Sciences
• Year: 2020
• Volume: 30
• Issue: 2
• Pages: 203-212

Contributors

author

E. Dhineshkumar

• Department of Chemistry, Annamalai University, Annamalainagar - 608 002, India

author

M. Arockia doss

• Department of Chemistry, St. Joseph University, Nagaland - 797 115, India

author

D. Uma

• Department of Chemistry, Pavai Arts and Science College for Women, Namkkal, Tamil Nadu - 637401, India

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• Document Type: article