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2020 | 30 | 2 | 203-212
Article title

Novel Synthesis, spectral, characterization of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole and its applications of molecular docking, anticancer activity

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Abstracts
EN
In the present study of 4,5-diphenyl-1-((tetrahydrofuran-2-yl)methyl)-2-(3,4,5-trichlorophenyl)-1H-imidazole 1 was synthesized. The synthesized imidazole compound 1 has been characterized by FT-IR, 1H, 13C NMR and ESI-Mass spectral studies. Molecular docking is also performed in order to explain the over-expression of estrogen receptor in 70% of liver cancer. The imidazole scaffold is a privileged scaffold for exploration of anticancer agents. The objective of the present study is to evaluate the anticancer activity of imidazole 1 in human liver cancer cell lines HepG2.
Keywords
Year
Volume
30
Issue
2
Pages
203-212
Physical description
Contributors
  • Department of Chemistry, Annamalai University, Annamalainagar - 608 002, India
  • Department of Chemistry, St. Joseph University, Nagaland - 797 115, India
author
  • Department of Chemistry, Pavai Arts and Science College for Women, Namkkal, Tamil Nadu - 637401, India
References
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Document Type
article
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.psjd-1805e336-e775-4524-8885-a5d78afd3192
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