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Article title

Związki endokrynnie czynne – prawdopodobieństwo niepożądanego działania środowiskowego

Title variants
Endocrine disrupting chemicals – probability of adverse environmental effect
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The paper presents some information about current state of knowledge of the risk due to exposure to endocrine disrupting chemicals (EDCs). Endocrine disruptors are defined as chemicals substances with either agonist or antagonist endocrine effects in human and wildlife. Exposure to EDCs in animals models correlate positively with an increased incidence of malformations of genital tract, on neoplasmas, obesity, alternations on male and female reproduction and changes in neuroendocrinology and behavior. Results from animal models, human clinical observations and epidemiological studies converge to implicate EDCs as a significant risk to public health.
Artykuł przedstawia aktualny stan wiedzy na temat ryzyka zdrowotnego, związanego z narażeniem na substancje endokrynnnie czynne (EDCs). Należą do nich związki chemiczne, wywierające działanie na układy hormonalne u ludzi i zwierząt. W eksperymencie na modelach narażenie na EDCs pozytywnie koreluje ze wzrostem przypadków malformacji genitalnych, zmian nowotworowych, otyłości, zaburzeniami reprodukcji, dyshormonozą endokrynologiczną, zmianami behawioralnymi. Wyniki badań modelowych, epidemiologicznych oraz obserwacji klinicznych wskazują na istnienie znacznego ryzyka dla zdrowia publicznego w wyniku działania EDCs.
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